Adenine base-pairing and stacking in d(AACCCC) and d(CCCCAA) by Narcisse Esmaili (6648)

“…The structures are shown looking down the helix axis from the 5′ end. The bond widths decrease with the base elevation. () [d(CCCCAA)]: stacking at the C4–A5 step in the 3′E intercalation topology and inter-duplex stacking of C1 between C4 and A5 in the 5′E topology. () [d(AACCCC)]: cross-strand stacking of A1 and A2 and intra-strand stacking at the A2–C3 step.…”

Data_Sheet_1_The Future Positive micro-intervention protocol: A program aiming to increase a healthy life-style among employees with a low socio-economic position.ZIP by Karen Schelleman-Offermans (9921594)

“…Matrices-of-change were produced in Step 2, and relevant methods and applications were selected in step 3. …”

Mithramycin Exerts an Anti-Myeloma Effect and Displays Anti-Angiogenic Effects through Up-Regulation of Anti-Angiogenic Factors by Eléonore Otjacques (410361)

“…In rat aortic ring assays, a strong anti-angiogenic effect was seen, which could be explained by a decrease of VEGF production and an up-regulation of anti-angiogenic proteins such as IP10 after MTM treatment. …”

Group I PAK Inhibitor IPA-3 Induces Cell Death and Affects Cell Adhesivity to Fibronectin in Human Hematopoietic Cells by Kateřina Kuželová (541883)

“…IPA-3 induced cell death with EC50 ranging from 5 to more than 20 μM. Similar range was found for IPA-3-mediated dephosphorylation of a known PAK downstream effector, cofilin. …”

Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation by Zeynep BAYRAMOGLU (13826448)

“…<div><p>Abstract The role of oxidative stress, as well as inflammation in the pathogenesis of methotrexate (MTX)-induced oral mucositis, is a known fact. The anti-inflammatory, antitumor, antimicrobial, and antioxidant properties of taxifolin—the effect we tested against MTX-induced oral mucosal damage—are well known. …”

Factors associated with the <i>SS</i> Positives. by Anuradha Rajamanickam (5278013)

“…<div><p><i>Strongyloides stercoralis (Ss)</i> is a parasitic infection affecting 50–100 million people globally, with significant immune and metabolic consequences, particularly in immunocompromised individuals. …”

Impact of the 2009 US Preventive Services Task Force Guidelines on Screening Mammography Rates on Women in Their 40s by Amy T. Wang (533749)

“…Time-series regression models were estimated to determine the effect of the guideline change on screening mammography rates. 5.5 million women ages 40–64 were included. A 1.8 per 1,000 women (p = 0.003) decrease in monthly screening mammography rates for 40–49 year-old women was observed two months following the guideline change; no initial effect was seen for 50–64 year-old women. …”

Down-regulation of PCNA increases the number of oocytes by alleviating the apoptosis of oocytes in fetal mouse ovaries. by Bo Xu (233514)

“…(<b>F</b>) mRNA expression of apoptosis-related genes was quantified by real-time PCR in PCNA RNAi and control ovaries 96 hours after transfection. Each bar represents a mean±s.d. of 20 (B), 12 (D) and 16 (E) ovaries from three or five independent experiments in different animals. #: P<0.05, ##: P<0.01, unpaired t test, *: P<0.05, **: P<0.01, student's t-test, compared with concurrent controls.…”

Synergistic effect of HDACi and EZH2i on schistosomula viability. by Letícia Anderson (2543926)

“…<p>(A) Schistosomula were treated with drugs in five different conditions: control with vehicle (DMSO + Ethanol); 20 μM GSK343; 50 μM GSK343; 1 μM TSA and 1 μM TSA + 20 μM GSK343. …”

Histopathology of spiral ganglion neurons in aged mice. by Yoshiaki Inuzuka (22386349)

“…The aged group shows a significant decrease in SGN density and SGN mitochondria number compared with the young group. …”

CRISPRi conditionally knocks down transcription across hundreds of <i>Eco</i> gene targets. by Kristine L. Trotta (16447243)

“…<p><b>a) CRISPRi induction produces mild transcriptional knockdown of endogenous <i>rfp</i> (11.7-fold decrease) in <i>Eco</i>.…”

The effect of matinal active walking on cognitive, fine motor coordination task performances and perceived difficulty in 12-13 young school boys by Elghoul Yousri (6015473)

“…After each trial, a questionnaire of perceived difficulty (PD) was completed. …”

Data_Sheet_1_Sepsis Disrupts Mitochondrial Function and Diaphragm Morphology.docx by Thamires Siqueira Oliveira (11398496)

“…Total and healthy mitochondria were reduced by 30% in septic mice, which may be associated with a 50% decrease in Ppargc1a (encoding PGC1a) and Opa1 (mitochondria fusion marker) expressions in the septic diaphragm. …”

The immune control exerted by lytic and non-lytic CD8+ T cell responses. by Nafisa-Katrin Seich al Basatena (201133)

“…Here we show the results for the non-lytic control that blocks viral infection, similar results were found for non-lytic control that blocks viral production (Figures S6, S7 in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003656#ppat.1003656.s001" target="_blank">Text S1</a> and data not shown). …”

Comparative Proteomics Unravels the Differences in Salt Stress Response of Own-Rooted and 110R-Grafted Thompson Seedless Grapevines by Sucheta Patil (8162292)

Data_Sheet_1_Evaluation of Brain Death in Laying Hens During On-Farm Killing by Cervical Dislocation Methods or Pentobarbital Sodium Injection.docx by Elein Hernandez (6678440)

“…Within 15 s after administration of pentobarbital sodium, there were significant decreases in mean frequency bands, increases in mean F50 and F95, and decreases in Ptot, suggesting brain death. …”

Data_Sheet_1_Effect of epidural spinal cord stimulation on female sexual function after spinal cord injury.docx by Claire Shackleton (13369920)

“…Sexual distress was reduced by 55%, with a mean decrease of 12 points (55.4%) from baseline (21.7 ± 17.2) to post-intervention (9.7 ± 10.8). …”

Table_1_Baseline mitochondrial DNA copy number and heart failure incidence and its role in overall and heart failure mortality in middle-aged women.pdf by Kristina Sundquist (83374)

“…Baseline levels of mtDNA-CN were quantified by droplet digital PCR in a population-based follow-up study of middle-aged (50–59 years) Swedish women (n = 2,508). …”

Image_2_Pulsed Infrared Stimulation of Vertical Semicircular Canals Evokes Cardiovascular Changes in the Rat.eps by Darrian Rice (10888116)

Image_6_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”