Loss of <i>bmm</i> function in the somatic cells of the gonad with an independent GAL4 line affects whole-body triglyceride breakdown in males but not females. by Lianna W. Wat (8339454)

“…(C) Between 0 and 12 hours STV, the magnitude of triglyceride breakdown in <i>tj>UAS-bmm-RNAi</i> was similar to <i>tj>+</i> and <i>+>UAS-bmm-RNAi</i> control males; however, between 12 and 24 hours STV, there was no significant decrease in triglyceride levels in <i>tj>UAS-bmm-RNAi</i> males, in contrast to <i>tj>+</i> and <i>+>UAS-bmm-RNAi</i> control males, in which we observed a significant decrease in triglyceride storage STV (<i>p</i> = 9.7 × 10⁻⁴, 0.0018, and 0.099 for 0–12 hours and 0.37, 1.9 × 10⁻⁵, and 0.028 for 12–24 hours, respectively; one-way ANOVA followed by Tukey HSD test). …”

Image_1_Modulation of low-dose ozone and LPS exposed acute mouse lung inflammation by IF1 mediated ATP hydrolysis inhibitor, BTB06584.tif by Pahul Singh (14781409)

“…Ozone and LPS exposure induced lung neutrophil and eosinophil recruitment as measured by respective peroxidase (MPO and EPX) assays, systemic leukopenia, increased levels of lung vascular neutrophil regulatory chemokines such as CXCL5, SDF-1, CXCL13 and a decrease in immune-regulatory chemokines such as BAL IL-10 and CCL27. …”

Image_2_Modulation of low-dose ozone and LPS exposed acute mouse lung inflammation by IF1 mediated ATP hydrolysis inhibitor, BTB06584.tif by Pahul Singh (14781409)

“…Ozone and LPS exposure induced lung neutrophil and eosinophil recruitment as measured by respective peroxidase (MPO and EPX) assays, systemic leukopenia, increased levels of lung vascular neutrophil regulatory chemokines such as CXCL5, SDF-1, CXCL13 and a decrease in immune-regulatory chemokines such as BAL IL-10 and CCL27. …”

Image_3_Modulation of low-dose ozone and LPS exposed acute mouse lung inflammation by IF1 mediated ATP hydrolysis inhibitor, BTB06584.tif by Pahul Singh (14781409)

“…Ozone and LPS exposure induced lung neutrophil and eosinophil recruitment as measured by respective peroxidase (MPO and EPX) assays, systemic leukopenia, increased levels of lung vascular neutrophil regulatory chemokines such as CXCL5, SDF-1, CXCL13 and a decrease in immune-regulatory chemokines such as BAL IL-10 and CCL27. …”

The mutation bias that maximizes <i>P</i>_peak correlates strongly with composition bias, measured using two definitions of accessible mutational paths. by Alejandro V. Cano (9427783)

53 proteins change in abundance with age. by Stephanie M. Zimmerman (449532)

<i>In-silico</i> identification of fingerprint of pyrazolyl sulfonamide responsible for inhibition of <i>N</i>-myristoyltransferase using Monte Carlo method with index of ideality... by Ashwani Kumar (55732)

“…The mechanistic interpretation of developed models explains the role of different structural attributes in predicting the pIC₅₀ of pyrazole sulfonamides extracted from the crystal structure of Leishmania major N-myristoyltransferase (NMT) along with co-crystallized myristoyl-CoA and ligands NMT106, NMT157, NMT187 and NMT236 (PDB ID: 4A2Z, 4A30, 4A32, 2WSA). …”

The Protein <i>O</i>-glucosyltransferase Rumi Modifies Eyes Shut to Promote Rhabdomere Separation in <i>Drosophila</i> by Amanda R. Haltom (664189)

“…The intracellular accumulation of Eys and the IRS defect worsen in <i>rumi</i> mutants raised at a higher temperature, and are accompanied by a ∼50% decrease in the total level of Eys. …”

Presentation_1_Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans.pdf by Emilia Boiadjieva Knöpfel (6795341)

“…We show that neutral amino acid antiporter LAT2 (Slc7a8) and uniporter TAT1 (Slc16a10) are expressed on mouse ciliary epithelium and LAT2 also in lens epithelium. …”

KRIT1 regulates steady-state levels of intracellular ROS. by Luca Goitre (245127)

“…Notice that KRIT1^−/− cells displayed the highest content of intracellular ROS, whereas the re-expression of KRIT1 caused a significant, expression level-dependent decrease in intracellular ROS levels.…”

Mechanisms involved in Sag-induced apoptosis. by Juliana Mundiñano (306020)

Data Sheet 1_Milciclib-mediated CDK2 inhibition to boost radiotherapy sensitivity in colorectal cancer.pdf by Junjie Ma (730463)

“…When combined with irradiation, Milciclib led to a 20% increase in the proportion of cells in the G1 phase and a 10% decrease in the G2 phase, suggesting an alteration in cell cycle distribution. …”

Table_1_The Impact of COVID-19 Confinement on Tinnitus and Hearing Loss in Older Adults: Data From the LOST in Lombardia Study.DOCX by Carlotta Micaela Jarach (12203687)

“…In 2020 compared to 2019, among individuals with tinnitus, those with increasing severity (5.0%) were similar to those decreasing it (5.3%). …”

Crz signaling influences osmotic and ionic stresses. by Meet Zandawala (491178)

Tumor necrosis factor (TNF) promotes the binding of nuclear proteins to the nuclear factor-kappa B (NF-κB) binding sequences of the vascular endothelial growth factor-C (VEGF-C) pr... by Qian Zhang (49333)

“…Values are the means of three mice plus standard deviation. The fold decrease in expression in the NF-κB inhibitor-treated over vehicle-treated cells was calculated. …”

Effect of mitomycin C (MMC) on Pgp-EGFP functionality studied with the Rho123 uptake assay. by Andreas Noack (519906)

“…As shown in the inset, this was correlated with a decrease of Pgp in the DRM fraction and an increase of Pgp in the detergent soluble fraction. …”

Data_Sheet_1_Assessment of Dog Owner Concern Regarding Peri-operative Nausea and Vomiting and Willingness to Pay for Anti-emetic Treatment.pdf by Bonnie L. Hay Kraus (7299392)

“…Fifty-three owners (51.4%) would definitely and 49/103 (47.6%) would likely choose treatment to prevent vomiting. The median and mean amount owners were willing to pay was 50 and 76.47 USD, respectively. …”

Robotic Thoracic Enucleation of Esophageal Leiomyoma by João Marcelo Lopes Toscano de Brito (11458365)

“…Because of the lesion’s anterior position relative to the trachea, it was felt it might be best accessed from the right chest. We also felt that potential risk of left recurrent laryngeal nerve injury may be decreased with a right-sided approach.…”

DataSheet_1_Stapled peptide PROTAC induced significantly greater anti-PD-L1 effects than inhibitor in human cervical cancer cells.docx by Yu-Ying Shi (15975992)

“…</p>Methods<p>We synthesized a stapled peptide-based PROTAC (SP-PROTAC) that specifically targeted palmitoyltransferase ZDHHC3 and resulted in the decrease of PD-L1 in human cervical cancer cell lines. …”

Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells by Antoine Nougairede (5649739)

“…<div><p>Large-scale codon re-encoding represents a powerful method of attenuating viruses to generate safe and cost-effective vaccines. …”