Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

High-dose thiamine prevents brain lesions and prolongs survival of <i>Slc19a3</i>-deficient mice by Kaoru Suzuki (4217638)

“…To investigate the molecular mechanisms of neurodegeneration in SLC19A3 deficiency and whether administration of high-dose thiamine prevents neurodegeneration, we generated homozygous Slc19a3 E314Q knock-in (KI) mice harboring the mutation corresponding to the human SLC19A3 E320Q, which is associated with the severe form of THMD2. …”

Occurrences of the hemoglobin safety composite endpoint (hemoglobin decrease of ≥40 g/L or ≥40% versus baseline or hemoglobin <50 g/L or blood transfusion) by G6PD genotype in the... by Zul Premji (215008)

Arginine starvation impacts <i>C</i>. <i>trachomatis</i> development in HeLa and C33A cells to an equivalent extent. by Shardulendra P. Sherchand (3133677)

SDG decreases iron-induced MMP gene expression in H9c2 cells. by Stephanie Puukila (568109)

The variant mimicking hyperphosphorylation of human 4E-BP does not decrease its association with eIF4E. by Nathalie Oulhen (373674)

Flowchart of patients. by Seydou Goro (17847203)

High levels of IFNγ partially restores <i>C</i>. <i>trachomatis</i> development in HeLa cells. by Shardulendra P. Sherchand (3133677)

Association of age and presence of comorbidities with the finding of a decreased GFR. by Regina C. R. M. Abdulkader (302450)

Kaplan-Meier survival graphs for serotypes A to G. by Andrew Emanuel (4610887)

Levels of the antioxidant enzyme, MnSOD are decreased in the cortical and hippocampal microvessels. by Susan A. Austin (768265)

Overexpresssion of cofilin, LIMK and occludin, but not claudin-1, significantly diminishes the capsaicin-induced decrease in TER. by Tomoko Shiobara (486327)

Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action by Christopher J. Zerio (11595690)

“…A medicinal chemistry campaign produced the novel eIF4A inhibitor <b>28</b>, which decreased BJAB Burkitt lymphoma cell viability. …”

Stat1 prevents the decrease of p27^Kip1 by activated Ras. by Shuo Wang (143908)

Can inoculation with diazotrophic bacteria decrease the productivity loss of defoliated Vigna unguiculata (L.) Walp? by Caliane da S. Braulio (10469226)

<i>Il-17c</i> deletion decreases the expression of inflammatory cytokines. by Giovanna Vella (6413774)

Regression phase leads to progressive decrease in percentage lipid area and macrophage foam cell content. by Vivek Khanna (473366)

Density increases cadherin-11 and GSK3β inhibitors decrease cadherin-11 expression. by Anne K. Farina (266373)

Circulating NETs components are higher in T2R patients, which decrease after thalidomide treatment. by Camila Oliveira da Silva (7365539)

HSF2 binds the ORF50 promoter and remodels the local chromatin landscape. by Lorenza Cutrone (21144285)