Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo by Zhiqiang Li (102723)

“…Treatment of such diseases with small-molecule NIK inhibitors is a reasonable but underexplored approach. In this paper, we reported the discovery of a potent and selective NIK inhibitor <b>46</b> (XT2). …”

Crz1 mediates masking in response to exogenous calcium. by Andrew S. Wagner (11331477)

The functions <i>G</i>_<i>k</i>(<i>L</i>) representing the <i>k</i>-components of the flow depending on the scale of coarse-graining <i>L</i>. by Vladimir A. Andryushchenko (4662829)

Silencing or suppression of TRPM7 inhibits cortical astrocyte proliferation. by Zhao Zeng (478844)

“…<p><b>A</b>. Representative images show the proliferation of astrocytes treated with control siRNA or TRPM7 siRNA. …”

House Dust Mite Allergen Regulates Constitutive Apoptosis of Normal and Asthmatic Neutrophils via Toll-Like Receptor 4 by Do Hyung Kim (739231)

Model of miRNA involvement in muscle response following BoNT/A-induced muscle paralysis. by Leah E. Worton (457030)

Venn diagram representing the RNA sequencing results. by Shyamasree De Majumdar (168216)

TRPM7 is down-regulated in mouse cortical astrocytes by siRNA. by Zhao Zeng (478844)

“…<p><b>A</b>. RT-PCR shows that transfection of astrocytes with specific TRPM7 siRNA decreases the mRNA level of TRPM7 compared to those with control siRNA. …”

CRISPRi knockdown of Lon protease to increase half-life. by Nicholas A. Rossi (3622865)

“…Bivariate scatter plots show P_<i>inaA</i> and P_<i>acrAB</i> expression levels at the final time point across n = 5 microcolonies. …”

Aging in mouse tail skin leads to an aberrantly weak inflammatory signature with decreased expression of <i>Lyz1</i>, <i>Lyz2</i>, <i>Clec7a</i>, <i>Cd48</i>, <i>Tyrobp</i> and <i>... by William R. Swindell (175427)

Video_1_Stability of Zircon and Its Isotopic Ratios in High-Temperature Fluids: Long-Term (4 months) Isotope Exchange Experiment at 850°C and 50 MPa.mov by Ilya N. Bindeman (2843150)

“…Debate, however, persists on how rapidly oxygen and key trace elements (e.g., Li, B, Pb) diffuse when zircon is exposed to silicate melt or hot aqueous fluids. Here, we report results of a nano- to micrometer-scale investigation of isotopic exchange using natural zircon from Mesa Falls Tuff (Yellowstone) treated with quartz-saturated, isotopically (¹⁸O, D, ⁷Li, and ¹¹B) labeled water with a nominal δ¹⁸O value of +450%0 over 4 months at 850°C and 50 MPa. …”

Presentation_1_Stability of Zircon and Its Isotopic Ratios in High-Temperature Fluids: Long-Term (4 months) Isotope Exchange Experiment at 850°C and 50 MPa.pdf by Ilya N. Bindeman (2843150)

“…Debate, however, persists on how rapidly oxygen and key trace elements (e.g., Li, B, Pb) diffuse when zircon is exposed to silicate melt or hot aqueous fluids. Here, we report results of a nano- to micrometer-scale investigation of isotopic exchange using natural zircon from Mesa Falls Tuff (Yellowstone) treated with quartz-saturated, isotopically (¹⁸O, D, ⁷Li, and ¹¹B) labeled water with a nominal δ¹⁸O value of +450%0 over 4 months at 850°C and 50 MPa. …”

Table_1_Stability of Zircon and Its Isotopic Ratios in High-Temperature Fluids: Long-Term (4 months) Isotope Exchange Experiment at 850°C and 50 MPa.XLS by Ilya N. Bindeman (2843150)

“…Debate, however, persists on how rapidly oxygen and key trace elements (e.g., Li, B, Pb) diffuse when zircon is exposed to silicate melt or hot aqueous fluids. Here, we report results of a nano- to micrometer-scale investigation of isotopic exchange using natural zircon from Mesa Falls Tuff (Yellowstone) treated with quartz-saturated, isotopically (¹⁸O, D, ⁷Li, and ¹¹B) labeled water with a nominal δ¹⁸O value of +450%0 over 4 months at 850°C and 50 MPa. …”

Loss of <i>FGR41</i> or <i>CWP419</i> does not impact susceptibility to cell wall stressors. by Andrew S. Wagner (11331477)

Overexpression of calcineurin effector genes does not restore calcium-induced masking in a <i>crz1Δ/Δ</i> mutant. by Andrew S. Wagner (11331477)

scRNAseq analysis of <i>Rx > </i>c<i>re Myrf</i>^<i>fl/fl</i> mice shows decrease in the RPE cell population. by Michelle L. Brinkmeier (18709048)

“…The RPE cluster is highlighted as having a smaller cell proportion in the mutant. (D) Bar charts show the decrease in cell number within the RPE mutant (M) cluster across each time point.…”

Physio-Biochemical Composition and Untargeted Metabolomics of Cumin (<i>Cuminum cyminum</i> L.) Make It Promising Functional Food and Help in Mitigating Salinity Stress by Sonika Pandey (834285)

“…Relative water content remained unchanged up to 50 mM NaCl stress, and thereafter decreased significantly. …”

Spiral-wave dynamics in the absence of fibroblasts () in a 2D simulation domain with myocytes of the mid-myocardial type. by Rupamanjari Majumder (128411)

Fig 3 - by George Rucker (17101889)

SARS-CoV-2 inhibition by MAP30 and Momordin. by Norman R. Watts (1964959)