HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

Constraint on the eclogite age of the Sanbagawa metamorphic rocks in central Shikoku, Japan by Shogo Aoki (6440666)

“…It is likely that the older unit was subducted into a depth of over 50 km and stagnated until the younger unit was subducted to the same depth. …”

IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya Severity by Lisa F. P. Ng (252501)

“…Statistical analysis showed that an increase in IL-1β, IL-6 and a decrease in RANTES were associated with disease severity.…”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

Primer pairs for RT-qPCR. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

Global Projections of 21^st Century Land-Use Changes in Regions Adjacent to Protected Areas by Linda J. Beaumont (140436)

“…For five periods across the 21^st century, we assessed changes to the extent of primary land, secondary land, pasture and crop land projected to occur within 50 km buffers surrounding IUCN-designated PAs. …”

Data_Sheet_1_Chicken Manure and Mushroom Residues Affect Soil Bacterial Community Structure but Not the Bacterial Resistome When Applied at the Same Rate of Nitrogen for 3 Years.do... by Shuang Peng (1409656)

“…A total of 262 ARG subtypes were detected in chicken manure using high-throughput qPCR, and heat treatment can effectively remove 50 types of ARGs. …”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

RT-qPCR data tables. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

Flavonoid biosynthesis pathway and the key genes along it. by Gustavo Roberto Fonseca de Oliveira (10739500)

Data_Sheet_1_Acidification and hypoxia drive physiological trade-offs in oysters and partial loss of nutrient cycling capacity in oyster holobiont.PDF by Deevesh Ashley Hemraj (15775310)

“…Microbes also seemed to have lost some capacity in nutrient cycling under hypoxia and multi-stressor conditions (~50% less nitrification) but not acidification.</p>Discussion<p>We show that the microbiota associated to the oyster can be enriched differently under climate change depending on the type of environmental change that the oyster holobiont is exposed to. …”

Results of mechanical analysis of SA and PLGA MN. by Yusuf K. Demir (475556)

“…MN failure was interpreted as the sudden decrease in force. (B) Mechanical analysis of polymeric PLGA (50∶50) MNs under axial loading. …”

AAV-hGATA-enhanced GFP (eGFP) vector construction and expression in the hippocampal neurons. by Miyeon Choi (648726)

“…CUS animals injected with KET showed a decrease in rGATA-2 mRNA compared with CUS animals (<i>P</i><0.05; <i>n</i> = 6 animals in each group). …”

Human glaucomatous trabecular cells produce SDF-1(5-67). by Alexandre Denoyer (160189)

“…MMP inhibitors batimastat (100 nM) and TIMP-1 (0.5 nM) induce a decrease in SDF-1(5-67) production, whereas TNF-α (50 ng/mL [2.9 nM]) and TGF-β2 (10 ng/mL [0.8 nM]) enhance the production of SDF-1(5-67). ** <i>P</i><0.01. …”

Managing Impending Non-Severe Hypoglycemia with Oral Carbohydrates in Type 1 Diabetes: The REVERSIBLE Trial. by Ran Cheng (8449275)

“…Following inpatient subcutaneous insulin-induced decrease in BG in the fasting state, 16g of oral CHO was administered at a plasma glucose (PG) of <70 mg/dL (3.9 mmol/L), ≤80 mg/dL (4.5 mmol/L) or ≤90 mg/dL (5.0 mmol/L). …”

Examining cardiac toxicity in HER2-positive breast cancer patients using trastuzumab and its influencing factors at Iran Hospital by Fatemeh Nasri (8290011)

“…The criteria for heart failure in this study were defined as an ejection fraction (EF) of less than 50% or a decrease of greater than 10% in EF. Descriptive statistics, the chi-square statistical test, Fisher’s exact test, and logistic regression analyses were employed to assess the variables. …”