Phase 1 study to evaluate the effects of rifampin or itraconazole on the pharmacokinetics of limertinib (ASK120067), a novel mutant-selective inhibitor of the epidermal growth fact... by Bei Cao (141848)

“…Coadministration of itraconazole increased the AUC_0-inf of limertinib by 289.8% (GLSM ratio, 389.8%; 90% CI, 334.07–454.82), but decreased that of CCB4580030 by 35.96% (GLSM ratio, 64.04%; 90% CI, 50.78–80.77).…”

Smoking impact on fibrosis and cancer gene expression. by Lorise C. Gahring (271630)

“…Even at this low magnification the increased dysplasia of the bronchial lining is visible (asterisks). Bar = 50 microns. B. Plots show the relative expression of selected pro-fibrotic genes in the α7^G or the α7^E260A:G and the relative impact of either LPS (from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187773#pone.0187773.ref007" target="_blank">7</a>]) or CS (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187773#pone.0187773.t002" target="_blank">Table 2</a>). …”

Expression levels of <i>Alox15</i>, <i>Hmox1</i> and <i>Fth1</i> in pulmonary myeloid cell populations. by Emilie Pollenus (10147748)

Data_Sheet_1_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.docx by Yue Shi (128342)

DataSheet1_The influence of drug-induced metabolic enzyme activity inhibition and CYP3A4 gene polymorphism on aumolertinib metabolism.docx by Feng Ye (173489)

“…The IC₅₀ values of telmisartan and carvedilol in CYP3A4.1 were 6.68 ± 1.76 μM and 0.60 ± 0.25 μM, respectively, whereas in CYP3A4.12, the IC₅₀ exceeded 100 μM. …”

S1 Data - by Xiaoguang Zhang (1397257)

Scores of each variable in the main components. by Leila Vahdatiraad (17382718)

“…Stellate sturgeon (<i>Acipenser stellatus</i>) fry, was exposed to diazinon (25, 50, and 75% of 96h-LC₅₀) for 6 days after pre-treatment with an HSP inducer (HSPi), TEX-OE^® (a prickly pear cactus extract), for 4 hours. …”

Effect of irradiation on GFAP immunostaining in mouse astroglia cells. by Nikolett Sándor (659792)

Effect of irradiation on claudin-5 immunostaining in mouse brain endothelial cells. by Nikolett Sándor (659792)

Boxplots of the data from Figure 2 for <i>K</i>^<i>trans</i> (A) and <i>v</i>_<i>e</i> (B). by Tavarekere N. Nagaraja (501546)

Microtomographic, histomorphometric, and molecular features show a normal alveolar bone healing process in iNOS-deficient mice along a compensatory upregulation of eNOS and nNOS is... by Carolina Fávaro FRANCISCONI (14820181)

“…Results The expression of iNOS had very low control conditions, whereas a significant increase is observed in healing sites of WT mice, where iNOS mRNA levels peak at 7d time point, followed by a relative decrease at 14d and 21d. …”

Comparison of mitral peak early diastolic filling velocity and peak late diastolic filling velocity in 139 lowlanders at the altitudes of 500 m, 3700 m and 4400 m. by Mingyue Rao (687325)

Microscopic examination of fetal placenta exposed to <i>U.simensis</i> essential oil: D-decidua, DA-decidual artery, DV-decidual vein, blue arrow head-maternal blood space, CBV-cho... by Bickes Wube (21678222)

Fig 1 - by Benazir Hodzic-Santor (14593183)

“…<p>Top 50 drugs with (A) greatest percentage increase and (B) greatest percentage decrease in average spending per beneficiary between 2014 and 2020.…”

Fig 3 - by Benazir Hodzic-Santor (14593183)

“…<p>Percentage change in beneficiaries for the top 50 drugs with (A) greatest increase and (B) greatest decrease in average spending per beneficiary between 2014 and 2020.…”

Table1_Integrated transcriptomics and proteomics assay identifies the role of FCGR1A in maintaining sperm fertilization capacity during semen cryopreservation in sheep.XLSX by Jiachen Bai (8449023)

“…The results showed that both the sperm viability (fresh group: 87.65% ± 4.17% vs. 75.8% ± 1.15%, cryopreserved group: 48.15% ± 0.63% vs. 42.45% ± 2.61%, p < 0.05) and motility (fresh group: 83.27% ± 4.15% vs. 70.41% ± 1.07%, cryopreserved group: 45.31% ± 3.28% vs. 35.13% ± 2.82%, p < 0.05) were significantly reduced in fresh and frozen sperm when FCGR1A was blocked. Moreover, the cleavage rate of embryos fertilized by FCGR1A-blocked sperm was noted to be significantly lower in both fresh (95.28% ± 1.16% vs. 90.44% ± 1.56%, p < 0.05) and frozen groups (89.8% ± 1.50% vs. 82.53% ± 1.53%, p < 0.05). …”

<i>T</i>. <i>spiralis</i> IIL ESP effect on Caco-2 cell viability. by Qi Qi Lu (17721401)

EBNA3C modulates RASSF1A expression in a ubiquitin-proteasome-dependent manner. by Shengwei Zhang (321384)

“…At the indicated time points, the cells were harvested and lysed for western blot. …”

Genetically altering the demand for PRPP modulates the sensitivity to Cu(II). by Javiera Norambuena (137228)

Schematic representation of the structure of the substrate in the model. by Eric Behle (11426692)