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81
Mesothelin expression and RG7787 uptake is decreased in KLM-1-R.
Published 2015“…<b>C</b>: At each time point, cellular uptake of RG7787-Alexa647 in KLM-1 is significantly higher than in KLM-1-R, and significantly lower than in KLM-1-R-<i>Msln</i> (transfected with mesothelin). …”
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The <i>P[syt<sup>P-L</sup>]</i> mutation decreases the Ca<sup>2+</sup> affinity of release and vesicular release probability, but the readily releasable pool is unchanged.
Published 2017“…<p>(A) Mean EJP amplitudes from <i>+/-;P[syt<sup>WT</sup>]/+</i> (filled black circles) and <i>+/-;P[syt<sup>P-L</sup>]/+</i> (filled red circles) larvae at Ca<sup>2+</sup> levels ranging from 0.05 mM—5.0 mM. …”
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88
Top Genes with Significantly Decreased Transcript Levels at the Site of SSTI<sup>1</sup>.
Published 2015“…<p><sup>1</sup>Top 50 genes with greatest negative change in LFC when comparing infected ears to uninfected ears from challenged mice for each time point represented</p><p><sup>2</sup>Function determined via Entrez (<a href="http://www.ncbi.nlm.nih.gov/" target="_blank">www.ncbi.nlm.nih.gov</a>) or Uniprot (<a href="http://www.uniprot.org/" target="_blank">www.uniprot.org</a>)</p><p><sup>3</sup>LFC = Log Fold Change</p><p>Italicized values indicate transcripts are significantly increased at the indicated time point.…”
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89
Aquaporin 2 Mutations in <i>Trypanosoma brucei gambiense</i> Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol
Published 2013“…The former encodes the well-characterized aminopurine permease P2 which transports several trypanocides including melarsoprol, pentamidine, and diminazene. We find that diminazene-resistant field isolates of <i>T. b. brucei</i> and <i>T. b. rhodesiense</i> carry the same set of point mutations in <i>TbAT1</i> that was previously described from lab mutants. …”
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91
Adaptation to cool temperature decreases basal and stimulated lipolysis and increases <i>de novo</i> lipogenesis and TAG synthesis.
Published 2021“…Rapid reduction of β3- and β2-adrenergic receptor mRNAs after exposure to 31°C (<i>n</i> = 6 per time point). Gene expression was normalized to geometric mean of <i>Hprt</i>, <i>Tbp</i>, and <i>Ppia</i> and is expressed relative to 37°C control (<i>n</i> = 4). …”
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Caspase-9 silencing decreases the expression of neuronal markers in differentiating NT2 cells.
Published 2013“…For each neuronal marker, the expression in control undifferentiated NT2 cells (day 0) was set at a value of 1. Each point represents the mean ± SD of three experiments. …”
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95
Nasal mucociliary clearance was decreased in <i>Ttll1</i><sup>−/−</sup> mice.
Published 2015“…The area occupied by contrast material is bordered with a red line. (D) We calculated the percent changes in the area of contrast material [(area at 30 min − area at 150 min)/area at 30 min] to assess clearance of contrast material (mean ± SEM, n = 4, *P < 0.005 by two-tailed Student's t test). …”
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Decreased sensitivity of coculture HIV spread to RAL predicts multiple infections per cell.
Published 2016“…Blue dashed line represents parametrization of the cell-free infection response to RAL in terms of IC<sub>50</sub> (1.9 nM) and hill coefficient (0.7). Red dashed line represents the fit of coculture infection using the decreased sensitivity to RAL (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005964#sec008" target="_blank">Materials and methods</a>). …”
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Inhibition of GLS1 decreases the proportion of CCR6 and CXCR3 expressing CD4<sup>+</sup> T cells.
Published 2016“…(B–C) The proportion of CCR6 expressing cells at day 3 (left) and day 5 (right) under normoxia (black bars) and hypoxia (grey bars) in the presence (+) and absence (-) of 25 μM BPTES and 50 μM 968. BPTES and 968 significantly decrease the proportion of CCR6 expressing cells under normoxia both at day 3 and 5, whereas 968 but not BPTES decrease the proportion of CCR6 expressing cells under hypoxia both at day 3 and 5. …”
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