CRIF1 deletion stimulated the activation of the NF-κB signaling pathway in HUVECs. by Shuyu Piao (4731327)

Atrial and ventricular connexins and sodium channel genes expression levels in wt and Ts65Dn mice. by Matthieu Raveau (160575)

“…Ts65Dn show an overall decrease in connexin and sodium channel mRNA expression except for <i>Cx45</i> and <i>Cx30.2</i> in the atria. …”

Cytoplasmic deadenylase Ccr4 is required for translational repression of <i>LRG1</i> mRNA in the stationary phase by Duong Long Duy (3775429)

“…In the log-phase <i>ccr4Δ</i> mutant cells, <i>LRG1</i> poly(A) tail was longer and <i>LRG1</i> mRNA level was higher than those in the log-phase wild-type (WT) cells. …”

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

Methodology. by Scott John (228011)

“…Upon binding of lactate YFP and CFP move farther apart, the intensity of YFP fluorescence decreases while that of CFP increases. This leads to a decrease in the YFP/CFP FRET ratio. …”

The actin nucleator Cobl decreases significantly in the ipsilateral hemisphere and in the primary motorcortex (M1) during the first hours after ischemic stroke induced by MCAO. by Yuanyuan Ji (455424)

T Cell Leukemia/Lymphoma 1A is essential for mouse epidermal keratinocytes proliferation promoted by insulin-like growth factor 1 by Antonella Bresin (5819432)

“…In particular, the colony-forming efficiency (CFE) and the insulin-like growth factor 1 (IGF1)-induced proliferation are dramatically impaired, while apoptosis is increased, in KCs from <i>Tcl1-/-</i> mice when compared to WT. …”

SIRT1 mediated CRIF1 deficiency-induced NF-κB activation in HUVECs. by Shuyu Piao (4731327)

Fig 2 - by Masaru Sakai (1669627)

Absence of Jag2 alleviates hypoxia-induced oxidative stress injury in rats. by Hanhan Liu (568151)

Nur77 expression by thymocytes and peripheral T cells in WT and Nur77Tg mice. by Ran Tao (81449)

“…Thymuses from WT or Nurr77Tg mice were stained with CD4, CD8, CD25 and CD44 Abs; left upper panel showed the proportions of single positive (CD4+ or CD8+), double positive and double negative cells, and left lower panel shows analysis of the double negative (DN) population 1–4 based on CD44 and CD25 expression. …”

Δ<i>ptsI</i> mutants are impaired for intramacrophage growth and virulence, with more decreased virulence in a Δ<i>glpD</i>/Δ<i>golD</i>/Δ<i>uhpT</i> background and can be trans-co... by Matthew J. Freeman (21094788)

Inhibition of Jag2 effectively ameliorates hypoxia-induced PH in rats. by Hanhan Liu (568151)

Jag2 expression is upregulated in hypoxia-treated rats and PASMCs. by Hanhan Liu (568151)

Change in per capita growth rate of intraspecies cooperating population implemented with a continuous model. by Yaron Goldberg (10164674)