Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Here, by addressing a high-energy water, we improved the IC₅₀ value of our co-crystallized glycogen synthase kinase-3β (GSK-3β) inhibitor by nearly two orders of magnitude. …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Here, by addressing a high-energy water, we improved the IC₅₀ value of our co-crystallized glycogen synthase kinase-3β (GSK-3β) inhibitor by nearly two orders of magnitude. …”

Optimal conditions for vigor indexes A and B. by Ahad Asghari (20615202)

“…The results revealed that increasing PAW levels up to 0.18 min/mL led to an increase in seed germination percentage, seedling weight (both fresh and dry), seedling length, vigor indexes A and B, and water uptake and decreasing mean germination time. …”

A37 increases the M1 protein stability and viral pathogenicity of H5N6 virus. by Chenxi Wang (284364)

Shared impact on transcriptome for the ORFs ETS2 and ZBTB40. by Mohamad Karaky (8910497)

Maternal separation (MS) did not affect the frequency of action potentials. by Jesús David Ayala-Rodríguez (17364296)

Multifunctional Hybrid Compounds Derived from 2‑(2,5-Dioxopyrrolidin-1-yl)-3-methoxypropanamides with Anticonvulsant and Antinociceptive Properties by Michał Abram (4490902)

“…Such hybrids demonstrated effectiveness in two of the most widely used animal seizure models, namely, the maximal electroshock (MES) test and the psychomotor 6 Hz (32 mA) seizure models. Compound <b>33</b> showed the highest anticonvulsant activity in these models (ED₅₀ MES = 79.5 mg/kg, ED₅₀ 6 Hz = 22.4 mg/kg). …”

Example protocol of a testing session. by Steven A. Thompson (22477818)

LD decay plots for A, B, D and whole genome. by Fatima Henkrar (17346528)

Loss of T37 phosphorylation protects M1 protein from degradation directed by PKG. by Chenxi Wang (284364)

Mitochondrial damage is a key event in the mechanism of oncosis in skeletal muscle cells. by Chengcheng Li (2591632)

Deregulation between miR-29b/c and DNMT3A Is Associated with Epigenetic Silencing of the CDH1 Gene, Affecting Cell Migration and Invasion in Gastric Cancer by He Cui (229445)

“…In 50 paired clinical GC tissue specimens, decreased miR-29b/c was significantly correlated with the degree of differentiation and invasion of the cells and was negatively correlated with DNMT3A expression. …”

Cell viability of canine cells treated with the autophagy inhibitor spautin-1, doxorubicin, or a combination, with spautin-1 applied pre-chemotherapy. by Courtney R. Schott (5904980)

Contact Theory [29] intervention components. by Rachel L. Knight (14147439)

“…<div><p>Robust evidence supports the role of physical activity and exercise in increasing longevity, decreasing morbidity and helping older adults maintain the highest quality of life attainable. …”

Features and Consequences of Isopropanol Burning off PTFE–rGO Aerogels by Sergey A. Baskakov (11324315)

“…An improved procedure for the preparation of aerogel granules of polytetrafluoroethylene–graphene oxide (PTFE–GO) with a composition of 50:50 (in wt %) and a specific density of 35 ± 2 mg/cm³ is described. …”

Supplementary Material for: Effect of Surface Perturbation Treadmill Training Program on Strategies and Kinematics of Reactive Stepping during Standing in Older Adults: A Single-Bl... by figshare admin karger (2628495)

“…Results: Both groups showed a significant decrease in the percentage of multiple-step responses (p=0.013) and a shorter total recovery time to recover balance (p=0.006). …”

VACV sA28 and sH2 <i>in vitro</i> protein binding analyses. by Chi-Fei Kao (11414234)

Molecular and metabolic percentage changes caused by treatment of pediatric glioblastoma cells with GDC-0941 or PI-103 (5×GI₅₀, 24 hours). by Nada M. S. Al-Saffar (454143)

Skin defects in <i>Hdh</i>^neoQ50/<i>Hdh</i>^ex4/5 hypomorphic embryos. by Vidya Murthy (6495386)

“…<b>A)</b> At E18.5, following toluidine-blue dye exclusion assay, WT animal shows a functional epidermal barrier but <i>Hdh</i>^neoQ50/<i>Hdh</i>^ex4/5 animal has a compromised epidermal barrier on the ventral surface. …”

No effects of fingolimod on spinal cord glutamate transporter protein levels during EAE. by De-Hyung Lee (356687)

“…At the maximum of EAE, there was a decrease for SLC1A2 (A,B) and SLC1A3 protein levels (C,D) as compared to naïve mice which was restored after fingolimod treatment (3 mg/kg once daily). …”