LCR activity and background Ca at low and high SR Ca pumping rate Pup of 4 mM/s and 24 mM/s as membrane depolarizes from the MDP (Maximal Diastolic Potential) to -50 mV (a threshol... by Alexander V. Maltsev (4229458)

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

A mechanism of non-target site resistance conferred by loss-of-function of <i>PAM16</i> is conserved in <i>M</i>. <i>polymorpha</i>. by Chloe Casey (14341756)

UV-irradiated M-phase cells show decreased MCM 2–7 loading and G1 arrest after release: HEK293 cells and U2OS cells. by Masayuki Morino (304956)

Heterogeneity of HASM membrane potential responses evoked by procontractile agonists co-treated with TAS2R agonists. by Blanca Camoretti-Mercado (762326)

NatB-inactivation decreased Drk levels through its N-terminal sequences, which was regulated by the N-end rule E3 ubiquitin ligase POE/UBR4. by Zhentao Sheng (107495)

4‑Aminoquinoline Antimalarials Containing a Benzyl­methyl­pyridyl­methyl­amine Group Are Active against Drug Resistant <i>Plasmodium falciparum</i> and Exhibit Oral Activity in Mic... by Mukesh C. Joshi (4670284)

“…These compounds exhibited significantly improved solubility and decreased lipophilicity and were potent against chloroquine-sensitive (NF54) and -resistant (Dd2 and 7G8) <i>P. falciparum</i> strains with 5/6 having IC₅₀ < 100 nM against the NF54 strain. …”

The <i>P[syt^P-L]</i> mutation decreases the Ca²⁺ affinity of release and vesicular release probability, but the readily releasable pool is unchanged. by Mallory C. Shields (4474210)

“…<p>(A) Mean EJP amplitudes from <i>+/-;P[syt^WT]/+</i> (filled black circles) and <i>+/-;P[syt^P-L]/+</i> (filled red circles) larvae at Ca²⁺ levels ranging from 0.05 mM—5.0 mM. …”

Flow chart describing samples. by Rabi Joël Gansaonré (20416803)

“…If a child’s growth changed from severe stunting to normal growth, their risk of repeating a grade decreased by 5.0 [95% CI: 0.0; 9.0] per 100 persons-years. …”

<i>miR26a</i> controls vSMC differentiation via <i>smad1</i>-mediated BMP signaling. by Charlene Watterston (6704078)

“…There is no significant decrease in <i>miR26a</i> knockdown embryos (two Way ANOVA, N = 3, <i>miR26a</i> MO n = 15, Wildtype n = 15, Unpaired t test, ****p< 0.0001 as compared to control, Error Bars = SEM. …”

The pax7 probe set enables simultaneous detection of all three <i>pax7</i> genes. by Cécile Rallière (86527)

Primary data set used for analysis. by Louis Lambrechts (241741)

“…Here, we report on a field-based study in the city of Iquitos, Peru, where we conducted direct mosquito feedings on people naturally infected with DENV and that experienced mild illness. …”

Urolithin A treatment slows reproductive decline in wild type. by Vanessa Cota (13833956)

DataSheet3_Rhubarb Enema Decreases Circulating Trimethylamine N-Oxide Level and Improves Renal Fibrosis Accompanied With Gut Microbiota Change in Chronic Kidney Disease Rats.PDF by Chunlan Ji (5712218)

DataSheet4_Rhubarb Enema Decreases Circulating Trimethylamine N-Oxide Level and Improves Renal Fibrosis Accompanied With Gut Microbiota Change in Chronic Kidney Disease Rats.docx by Chunlan Ji (5712218)

DataSheet2_Rhubarb Enema Decreases Circulating Trimethylamine N-Oxide Level and Improves Renal Fibrosis Accompanied With Gut Microbiota Change in Chronic Kidney Disease Rats.PDF by Chunlan Ji (5712218)

DataSheet1_Rhubarb Enema Decreases Circulating Trimethylamine N-Oxide Level and Improves Renal Fibrosis Accompanied With Gut Microbiota Change in Chronic Kidney Disease Rats.PDF by Chunlan Ji (5712218)

miR-200c regulates migration associated genes such as filamin A. by Bojan Ljepoja (4921255)

“…<p>(a) A proteomic analysis of a TALENs knock-out (KO) of miR-200c in MCF7 cells revealed a set of proteins with differential expression, of which 50% are involved in migratory processes and are shown in the table. …”

Pre-diabetes is associated with increased risk of heart failure among patients with atrial fibrillation by Jia-Yi Huang (12733928)

“…Compared to those who remained pre-diabetic, patients who progressed to diabetes were associated with an increased risk of HF (SHR=1.50, 95% CI: 1.13-1.97), whereas those who reversed to normoglycaemia were associated with decreased risk (SHR=0.61, 95% CI: 0.42-0.94). …”