Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1 by María Dolores Moya-Garzón (5597540)

“…We introduce here an unprecedented activity of salicylic acid derivatives as agents capable of decreasing oxalate output in hyperoxaluric hepatocytes at the low micromolar range, which means a potential use in the treatment of PH1. …”

An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos by Sergio Jarque (5698859)

“…<div><p>The knowledge on environmentally relevant chemicals that may interfere with thyroid signaling is scarce. Here, we present a method for the screening of goitrogens, compounds that disrupt the thyroid gland function, based on the automatic orientation of zebrafish in a glass capillary and a subsequent imaging of reporter gene fluorescence in the thyroid gland of embryos of the transgenic zebrafish line tg(tg:mCherry). …”

Pain score based on ear position according to MGS method. by Veronica Redaelli (7586621)

“…B: STEP-2, BUP+CAR treatment statistically decreased pain score 24 hours after surgery. …”

Study design. by Veronica Redaelli (7586621)

Effect of BNN27 treatment on paw grip endurance (PaGE) and rotarod in male and female mice. by Kelly E. Glajch (3204465)

“…<p>Male Tg vehicle-treated mice demonstrated a significant decrease in time spent on the PaGE test (a, left) at p95 (p = 0.0023, Mann-Whitney <i>U</i> test), p115 (p = 0.0003, Mann-Whitney <i>U</i> test), and p135 (p = 0.0385, Mann-Whitney <i>U</i> test) and the rotarod test (b, left) at p55 (p = 0.0089, Mann-Whitney <i>U</i> test), p95 (p = 0.0192, Mann-Whitney <i>U</i> test), and p135 (p = 0.0152, Mann-Whitney <i>U</i> test) relative to Wt vehicle-treated mice. …”

Additional measures to characterize (A) actin filament and (B) motor protein organization in simulations using baseline parameter values (Table 1). by Maria-Veronica Ciocanel (9565099)

“…The parameter values used are <i>d</i>_step = 6 nm, <i>k</i>_head.bind = 0.2/s, <i>F</i>_s = 100 pN, range_heads = 15–30 (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1010026#pcbi.1010026.t001" target="_blank">Table 1</a>). …”

Hypoxia Resistance of Sterile Mutants. by Cassidy Hemphill (12667290)

Effect of BNN27 treatment on body weight and neurological score in male and female mice. by Kelly E. Glajch (3204465)

“…<p>Tg vehicle-treated mice (males and females combined) exhibited a significant decrease in percent weight relative to baseline levels (a, left) at p105 (p = 0.0188, Mann-Whitney <i>U</i> test), p115 (p = 0.0025, Mann-Whitney <i>U</i> test), p125 (p<0.0001, Mann-Whitney <i>U</i> test), p135 (p<0.0001, Mann-Whitney <i>U</i> test), and p145 (p<0.0001, Mann-Whitney <i>U</i> test) compared to Wt vehicle-treated mice. …”

Boundary between subtractive and divisive inhibition in (<i>g</i>_{<i>Syn</i>,<i>E</i>}, <i>g</i>_<i>A</i>) parameter space. by Joshua H. Goldwyn (339094)

“…In <b>A</b>: We vary inhibition strength (<i>g</i>_{<i>Syn</i>,<i>I</i>} = 0.5, 1, 2) and keep inhibition rate fixed at 50 Hz. …”

Probability density distributions of time intervals between productions of consecutive RNA molecules in individual cells in three conditions in the second hour following the applic... by Anantha-Barathi Muthukrishnan (636329)

Transgenerational hormetic effects of sublethal dose of flupyradifurone on the green peach aphid, <i>Myzus persicae</i> (Sulzer) (Hemiptera: Aphididae) by Qiuling Tang (495407)

“…<i>persicae</i> with a 48 h LC₅₀ of 8.491 mg/L. Using the age-stage two-sex life table approach, we assessed the effects of LC₂₅ of flupyradifurone on adult <i>M</i>. …”

Bi-plot presenting the correlation between the tested antioxidant parameters of tomato transplants (A) and ordination illustrating differences between substrates tested towards the... by Robert Pokluda (8871407)

Effects of Extracts from Thai Piperaceae Plants against Infection with <i>Toxoplasma gondii</i> by Arpron Leesombun (2805217)

“…<i>sarmentosum</i> are against <i>Toxoplasma gondii</i> infection <i>in vitro</i> and <i>in vivo</i>. Individually, we extracted the piperaceae plants with ethanol, passed them through a rotary evaporator and then lyophilized them to obtain crude extracts for each one. …”

Potential corner case cautions regarding publicly available implementations of the National Cancer Institute’s nonwear/wear classification algorithm for accelerometer data by Hyatt E. Moore IV (536880)

“…The number of participants with four or more valid days increased 2.29% (n = 113) and mean CPM dropped 2.45% (9.5 CPM) when adjusting the nonwear classification threshold to 50 counts an hour. Applying the most liberal criteria, only excluding hours as nonwear which contained 1 count or less, resulted in a 397 more participants (7.83% increase) and 26.5 fewer CPM (6.98% decrease) in NHANES 2003–2004 participants with four or more valid days. …”

Likelihood-ratio test P values between pairs of models for each condition. by Anantha-Barathi Muthukrishnan (636329)

Selective Lability of Ruthenium(II) Arene Amino Acid Complexes by Tom G. Scrase (1355994)

VAMP2 Is Engaged in Loose SNARE Complexes before the Efflux of Intra-Acrosomal Ca²⁺ by Gerardo A. De Blas (262394)

“…However, the toxins decreased the VAMP2 labeling when present during stimulation (B-AM→neurotoxin→Ca²⁺). …”

The Effect of Discontinuing Continuous Glucose Monitoring in Adults with Type 2 Diabetes Treated with Basal Insulin by Grazia Aleppo (8550433)

“…</p> <p><b>Results: </b>In the group that discontinued CGM, mean time in range 70-180 mg/dL (TIR), which improved from 38% prior to initiating CGM to 62% after 8 months of CGM, decreased after discontinuing CGM to 50% at 14 months (mean change from 8 to 14 months = -12%, 95% CI -21% to -3%, P=0.01). …”

IRT measurements. by Veronica Redaelli (7586621)

Fig 5 - by Rongqing Chen (249906)