Protein-protein docking for Parkin and a charged E2∼Ub complex. by Thomas R. Caulfield (655752)

“…<b>C</b>) Following unbiased MD (>200 ns), the E2-Ub complex moves towards the Parkin's active center. The decreased distance is shown after 50 ns. <b>D</b>) Overall re-orientation of the UBL domain and the E2-Ub complex is shown after 200 ns.…”

RIPK3 enhances innate anti-viral immunity against Influenza A virus. by Jeffrey Downey (3927356)

<i>miR-146a</i> expression in tissue and plasma of OSCC patients. by Pei-Shi Hung (489732)

Bleeding Risk and Mortality of Edoxaban: A Pooled Meta-Analysis of Randomized Controlled Trials by Shuang Li (146392)

Statins and Hip Fracture Prevention – A Population Based Cohort Study in Women by Arja Helin-Salmivaara (123653)

“…When women with poor (<40%), moderate (40 to 80%), and good adherence (≥80%) to statins were compared to those with good adherence to hypertension drugs (≥80%) or to the population cohort, the protective effect associated with statin use attenuated with the decreasing level of adherence.</p> <h3>Conclusions</h3><p>5-year exposure to statins is associated with a reduced risk of low-energy hip fracture in women aged 50–80 years without prior hospitalizations for fractures.…”

Antimycin A has broad spectrum antiviral activity against RNA viruses. by Avi Raveh (493231)

“…The calculated IC₅₀ value for antimycin A in the HCV replicon system is shown on the graph. …”

Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment by Phung Nguyen (230474)

“…The <b>CHBC</b>–GPR17 interaction leads to a rapid decrease of cAMP and Ca²⁺. <b>CHBC</b> exhibits the cytotoxicity effect on GBM cells in a dose-dependent manner with an IC₅₀ of 85 μM, whereas the known agonist MDL29,951 showed a negligible effect. …”

Disease course of Chronic Relapsing Inflammatory Optic Neuropathy (CRION) in a single care center by Luis Enrique MOLINA-CARRIÓN (12687286)

“…Objective: To describe the clinical course during long-term follow-up of patients with a diagnosis of CRION. Methods: From a cohort of 1,735 patients with demyelinating disorders, we selected patients aged over 16 years with CRION according to current criteria. …”

Data_Sheet_1_Effect of a High Fat Diet vs. High Carbohydrate Diets With Different Glycemic Indices on Metabolic Parameters in Male Endurance Athletes: A Pilot Trial.docx by Denise Zdzieblik (12399730)

“…The purpose of this trial was to investigate the effect of a 4-week high fat low carbohydrate (HFLC-G: ≥65% high glycemic carbohydrates per day; n = 9) vs. high carbohydrate low glycemic (LGI-G: ≥65% low glycemic carbohydrates daily; n = 10) or high glycemic (HGI-G: ≥65% fat, ≤ 50 g carbohydrates daily; n = 9) diet on fat and carbohydrate metabolism at rest and during exercise in 28 male athletes. …”

Measuring and Reducing Chemical Spills by Students: A Randomized Controlled Trial of Providing Feedback by Aimilia M. Tsokou (7272506)

“…A Hodges–Lehmann estimator for the median change in volume spilled during the second experiment due to providing feedback on spillage during first experiment was a 50% decrease in volume spilled (95% confidence range: 0 to 80% decrease, Mann–Whitney <i>U</i> test <i>p</i> = 0.05). …”

A prospective study of the influence of the skeleton on calcium mass transfer during hemodialysis by Patricia Taschner Goldenstein (5570870)

“…</p><p>Results</p><p>Calcium mass transfer varied widely among patients in each study phase with a median of -89.5, -76.8 and -3 mmol using d[Ca] 1.25 mmol/L, -106, -26.8 and 29.7 mmol using d[Ca] 1.50 mmol/L, and 12.8, -14.5 and 38 mmol using d[Ca] 1.75 mmol/L during pre-PTX, early post-PTX and late post-PTX, respectively, which was significantly different among d[Ca] (p = 0.0001) and among phases (p = 0.040). …”

Intestinal microbial diversity comparison. by Xinjun Hu (412383)

DataSheet_1_Icanbelimod (CBP-307), a next-generation Sphingosine-1-phosphate receptor modulator, in healthy men: pharmacokinetics, pharmacodynamics, safety, and tolerability in a r... by Jason Lickliter (18073228)

“…After single-dose 0.5 mg, although a high-fat breakfast versus fasting did not affect maximal decrease, lymphocyte counts tended to be lower after breakfast across most timepoints up to 72 hours. …”

CPI-1612 represses a subset of enhancers which are linked to differentially expressed genes. by Archana Bommi-Reddy (4104961)

“…RNA-seq, H3K27ac ChIP-seq, and ATAC-seq tracks are plotted at the bottom, with H3K27ac and ATAC-seq peaks showing at least a 2-fold decrease marked with a *. The inset shows the differential ATAC-seq peaks in the <i>ELF3</i> enhancer.…”

<i>miR-146a</i> LNA treatment inhibits OSCC oncogenicity. by Pei-Shi Hung (489732)

“…The folds are determined by normalization of tumor volume at different time points to the tumor volume at the time point receiving the injection of <i>miR-146a</i> LNA. …”

Raw data. by Guohui Zhao (4668682)

“…Using the YSV dynamic acceleration signal acquisition system and a portable radar speed gun collect data on racket acceleration, stress-strain signals, and ball speed from 15 male athletes. …”

The participants information. by Guohui Zhao (4668682)

“…Using the YSV dynamic acceleration signal acquisition system and a portable radar speed gun collect data on racket acceleration, stress-strain signals, and ball speed from 15 male athletes. …”

A high seroprevalence of antibodies to pertussis toxin among Japanese adults: Qualitative and quantitative analyses by Takumi Moriuchi (4237807)

TBI accelerated extracellular Aβ deposits in the cortex of AD mice that received TBI. by Naoki Tajiri (106215)

“…Immunofluorescence for the detection of extracellular Aβ deposits and MAP2 (Panel C). Scale bars = 50 µm. …”

A low threshold K⁺ current determines the long refractory period. by Javier Nogueira (348174)

“…E) Pair pulses applied at different delays shows a long lasting refractory period. F) As expected for a low threshold K⁺ conductance, refractoriness was shortened after the application of 50 microMolar 4-aminopyridine to the bath.…”