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5 w » 5 wt (Expand Search)
we decrease » _ decrease (Expand Search), mean decrease (Expand Search), teer decrease (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
w decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
5 w » 5 wt (Expand Search)
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Introducing the 4‑Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates
Published 2016“…Herein we report the synthesis, anticancer potency <i>in vitro</i>, biomolecule interaction, and preliminary mode of action studies of a series of cyclometalated 1,2,3-triazole-derived ruthenium(II) (<b>2a</b>–<b>e</b>) and osmium(II) (<b>3a</b>–<b>e</b>) organometallics of the general form [(η<sup>6</sup>-<i>p</i>-cym)RuCl(κ<sup>2</sup>-C^N-L)] with varying substituents in postion 1 of the 1,2,3-triazole moiety. …”
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4656
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Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in <i>Trypanosoma cruzi</i>
Published 2017“…Isotretinoin inhibited the polyamine transport, as well as other amino acid transporters from the same protein family (<i>Tc</i>AAAP), with calculated IC<sub>50</sub> values in the range of 4.6–10.3 μM. It also showed a strong inhibition of trypomastigote burst from infected cells, with calculated IC<sub>50</sub> of 130 nM (SI = 920) being significantly less effective on the epimastigote stage (IC<sub>50</sub> = 30.6 μM). …”
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4660
<i>Bbs1</i><sup><i>M390R/M390R</i></sup> mice have decreased hippocampal proliferation.
Published 2021“…The Red Bar line represents 50μm. G.) Decreased proliferation in the dentate gyrus of P3 <i>Bbs1</i><sup><i>M390R/M390R</i></sup> mice. …”