image1_Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways.tif by Xin Zhi (1829224)

“…Specifically, myostatin increased the phosphorylation of Smad2, which led to the activation of NF-κB and MAPK pathways to activate osteoclastogenesis. Ccdc50 was identified as a gene whose expression was highly decreased in osteoclastogenesis upon myostatin treatment, and it could inhibit the function of myostatin in osteoclastogenesis by blocking NF-κB and MAPKs pathways. …”

image3_Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways.tif by Xin Zhi (1829224)

“…Specifically, myostatin increased the phosphorylation of Smad2, which led to the activation of NF-κB and MAPK pathways to activate osteoclastogenesis. Ccdc50 was identified as a gene whose expression was highly decreased in osteoclastogenesis upon myostatin treatment, and it could inhibit the function of myostatin in osteoclastogenesis by blocking NF-κB and MAPKs pathways. …”

image2_Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways.tif by Xin Zhi (1829224)

“…Specifically, myostatin increased the phosphorylation of Smad2, which led to the activation of NF-κB and MAPK pathways to activate osteoclastogenesis. Ccdc50 was identified as a gene whose expression was highly decreased in osteoclastogenesis upon myostatin treatment, and it could inhibit the function of myostatin in osteoclastogenesis by blocking NF-κB and MAPKs pathways. …”

image2_Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways.tif by Xin Zhi (1829224)

“…Specifically, myostatin increased the phosphorylation of Smad2, which led to the activation of NF-κB and MAPK pathways to activate osteoclastogenesis. Ccdc50 was identified as a gene whose expression was highly decreased in osteoclastogenesis upon myostatin treatment, and it could inhibit the function of myostatin in osteoclastogenesis by blocking NF-κB and MAPKs pathways. …”

Among novel KOR antagonists, PF-04455242 stands out as activating a current. by Elyssa B. Margolis (7933838)

Native PAGE experiments on SL1-wt RNA kissing dimer (KD) in the presence of sub-stoichiometric amounts of NCp7, run in the TBE buffer by Anwer Mujeeb (29896)

Description of kinematic variables measured during take-off to a jump. by Leena Inkilä (20614460)

Effect of CXB and DMC combinations on P-glycoprotein protein content and activity of P-glycoprotein in HeLa (A) and SiHa cells (B). by Diana Xochiquetzal Robledo-Cadena (5265959)

Peak systolic velocity (Vmax, m/s) and Doppler-derived pressure gradient (ΔP, mmHg) in Newfoundland dogs for which the board-certified specialist (VC) in charge of the French cardi... by Valérie Chetboul (579758)

Cytidine-phosphate-guanosine oligodeoxynucleotides in combination with CD40 ligand decrease periodontal inflammation and alveolar bone loss in a TLR9-independent manner by Qian Zhao (217607)

“…The silk ligature was tied around the maxillary second molars for 14 days, during which the CpG+CD40L mixture or PBS was injected into palatal gingiva on days 3, 6, and 9. Results: For both WT and TLR9 KO mice, CpG significantly induced B cell proliferation, increased IL-10 mRNA expression and protein secretion of IL-10 but reduced CD1dhiCD5+ B cells population; local injection of CpG+CD40L mixture significantly decreased alveolar bone loss and the number of TRAP-positive cells adjacent to the alveolar bone surface, and significantly increased the gingival mRNA expression of IL-10 and decreased RANKL and IFN-γ mRNA expression. …”

Diarrheal stool output rate overall and by blood type status in the modified intent-to-treat population. by Rahsan Erdem (11726357)

Inhibition experiments with PP PLA₂. by Catherine A. Vulfius (676708)

SDS-PAGE analysis of enzymes. by Lina Liu (227490)

<i>neurod1</i>^<i>ΔUCE</i> homozygous mutants display a decrease in the expression of several EE hormones. by Anne Sophie Reuter (12239993)

Loss of expression of <i>dbt</i> in <i>tim-</i>GAL4-expressing neurons can lead to a sleep decrease during the nighttime, while loss of expression of <i>dbt</i> with <i>per-</i>GAL... by Jialin Wang (490082)

Results for the cross-validated hyperparameter search. by Katharina Ledebur (11781928)

Representative images of the right eye of a 51-year-old woman with active central serous chorioretinopathy. by Dae Joong Ma (5687885)

Effects of 50 µM stearic acid, oleic acid and linoleic acid on cell death and apoptosis of 3T3L1 preadipocytes. by Ming-Che Shen (629982)

Loss of exostosin-1 (EXT1), specific reduction of heparan sulfate (HS) in fibroblasts, and decreased acidic mucosubstances in the stroma of <i>S100a4-Cre; Ext1</i><sup><i>f/f</i></... by Ayumi Niwa (6256790)

The Anion [Mg₆Cl₈Cp*₅]^-:  A Final Intermediate on the Way to the Molecular Donor-Free Grignard Compound MgClCp*? by Jean Vollet (2644651)

“…The reaction at −70 °C of decamethylmagnesocene MgCp*₂ (Cp* = pentamethylcyclopentadienyl) with monovalent aluminum chloride, AlCl, stabilized with diethyl ether and dissolved in toluene, results in tetrameric tetrahedrotetrakis(pentamethylcyclopentadienylaluminum), [AlCp*]₄, and the dimeric bis(pentamethylcyclopentadienylmagnesium chloride diethyl etherate), [MgCp*Cl·Et₂O]₂. At a slightly higher temperature and by stepwise decrease of the diethyl ether concentration before reaction, a preferred formation of metal clusters such as dodekakispentamethylcyclopentadienylpentaconta-aluminum, Al₅₀Cp*₁₂, was frequently observed. …”