Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

LCs and cDC1s play redundant roles in anti-flu and SARS-CoV-2 adaptive immune responses triggered by the mRNA-LNP platform. by Sonia Ndeupen (11993937)

Table_2_Commonly Reported Problems and Coping Strategies During the COVID-19 Crisis: A Survey of Graduate and Professional Students.DOCX by Akash R. Wasil (9677355)

“…Background<p>The COVID-19 crisis has introduced a variety of stressors, while simultaneously decreasing the availability of strategies to cope with stress. …”

Table_3_Commonly Reported Problems and Coping Strategies During the COVID-19 Crisis: A Survey of Graduate and Professional Students.DOCX by Akash R. Wasil (9677355)

“…Background<p>The COVID-19 crisis has introduced a variety of stressors, while simultaneously decreasing the availability of strategies to cope with stress. …”

Table_1_Commonly Reported Problems and Coping Strategies During the COVID-19 Crisis: A Survey of Graduate and Professional Students.DOCX by Akash R. Wasil (9677355)

“…Background<p>The COVID-19 crisis has introduced a variety of stressors, while simultaneously decreasing the availability of strategies to cope with stress. …”

Brain regions (ROIs) showing significantly increased ReHo in StD group (decreased ReHo in NC) (two sample <i>t</i>-test, thresholded at <i>p</i><0.005 with an extent threshold 5 co... by Zhenling Ma (290924)

Lack of neutrophils at the time of immunization does not affect the induction of adaptive immune responses by the mRNA-LNP platform. by Sonia Ndeupen (11993937)

pMCID depiction. by Martin M. Monti (9704273)

“…(Note: While not depicted, the calculation also includes “net” 1-point changes; e.g., where a 1-point decrease is observed in one subscale and a 2-point increase is observed on a different subscale; see methods for full detail).…”

Coefficients and 95% confidence intervals for the patient multinomial logit of choosing each item as “most concerning” versus “least concerning”. by Samuel W. Terman (13584382)

Risk of bias assessment. by Eleftherios G. Kaklamanos (4268746)

Excluded studies, with reasons. by Eleftherios G. Kaklamanos (4268746)

Eligibility criteria. by Eleftherios G. Kaklamanos (4268746)

Quality of available evidence. by Eleftherios G. Kaklamanos (4268746)

Graphical distribution of mutations from Table 1. by Abdulaziz B. Hamid (13804692)

Nrf2 is necessary for optimal PMN migration toward CXCL12 and CXCL2 without regulating receptors expression. by Doumet Georges Helou (7255823)

Map of US with region, state, and clinic sites of WHIMS participants. by Diana Younan (4662949)

IL-6 is required for the induction of adaptive immune responses by the mRNA-LNP platform. by Sonia Ndeupen (11993937)