Image 5_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mi... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 1_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 4_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Id2 down regulation drives Neuro2a AD cells towards the AI phenotype. by Lina Chakrabarti (501389)

“…<p>(<b>A, B</b>) BrdU incorporation assay demonstrated that transfection of AD cells with Id2-siRNA reduced the rate of proliferation. …”

Effects of bortezomib on OATP1B3-mediated transport. by Khondoker Alam (1443499)

Kinetics of Quartz Dissolution in Natural Silicate Melts and Dependence of SiO₂ Diffusivity on Melt Composition by Yi Yu (28902)

“…Combined with other data from our lab and literature, we show that ln <i>D</i>_SiO₂ decreases linearly with <i>X</i> (= Si + Al cation mole fraction) in rhyolitic to andesitic to basaltic melts, instead of just the SiO₂ concentration. …”

Kinetics of Quartz Dissolution in Natural Silicate Melts and Dependence of SiO₂ Diffusivity on Melt Composition by Yi Yu (28902)

“…Combined with other data from our lab and literature, we show that ln <i>D</i>_SiO₂ decreases linearly with <i>X</i> (= Si + Al cation mole fraction) in rhyolitic to andesitic to basaltic melts, instead of just the SiO₂ concentration. …”

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for males. by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for those who had an unhealthy diet (HEI below zero) at baseline. by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for those defined to be overweight (85% limit). by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for age group 15y3m. by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for baseline dietstratum 2 where the tailored SMS program targeted FV. by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for those defined to be underweight or normal weight (85% limit). by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for age group 14y3m. by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for baseline dietstratum 3 where the tailored SMS program targeted SSB. by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for baseline dietstratum 4 where the tailored SMS program (also) targeted Fish. by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for females. by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for all adolescents (the whole trial population). by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for age group 14y9m. by Anne Ahrendt Bjerregaard (7377500)

Main results for effects on mini-HEI and BMI z-scores, and SSB, FV and Fish z-scores, for baseline dietstratum 1 where the tailored SMS program targeted Fish. by Anne Ahrendt Bjerregaard (7377500)