Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Efficient assembly of CENP-A at centromeres requires SMC2. by Alexander Samoshkin (260480)

“…<p>A) CENP-A levels are not significantly decreased in condensin-depleted cells. …”

Elasticity values for variables for a simulated population of female fishers. by Roger A. Powell (21222116)

Image1_Phytochemical and toxicological evaluation of Zephyranthes citrina.JPEG by Muhammad Haseeb Ur Rehman (13848379)

“…Uric acid was raised at a dose of 100 mg/kg. In acute toxicity, at 2000 mg/kg, creatinine and uric acid increased while urea levels decreased. …”

Aggregation index (AI, %) and disaggregation threshold (γ at dISCmin, 1/sec) during weight reduction protocols. by Woo Hwi Yang (723342)

SIRT3 and SOD2 transcription. by Rafael A. Casuso (4487788)

“…<p>The SIRT3 mRNA levels were unchanged at all the time points and swimming intensities examined (A). SOD2 mRNA levels decreased at post in response to HIHVT (B). …”

MscS protects cells from β-lactam antibiotics. by Piotr Koprowski (742939)

PGC-1α downstream transcripts. by Rafael A. Casuso (4487788)

Proliferation of NG2+ cells in response to systemic lipopolysaccharide treatment. by Malin Wennström (289876)

Alpha rhythm cluster. by Eduardo Ekman Schenberg (801650)

“…B) Post-hoc analysis revealed decreases in the cluster depicted at left to be significant after 50 minutes from ingestion of ayahuasca (*p<0.05, corrected). …”

RBC nitrite concentration and maximum deformability (EI max) during weight reduction protocols. by Woo Hwi Yang (723342)

Fidelity of reassortment inference. by Mara Villa (2855789)

Swimming protocols differ in blood lactate production and perceived exertion but not in heart rate. by Rafael A. Casuso (4487788)

“…<p>Swimming performance, in terms of percentage of maximal speed, decreased in response to SIT (squares) after the sixth bout, while it remained stable during the HIHVT protocol (triangles) (A). …”

Negative selection on reassortment. by Mara Villa (2855789)

RBC-NOSSer1177 levels during weight reduction protocols. by Woo Hwi Yang (723342)

Pooling observations. by Stijn Bruneel (8113409)

Proliferation and supernatant sNG2 levels of cultured human NG2 cells after exposure cytokines. by Malin Wennström (289876)

Response rate of patients with <i>CYP3A4</i> and <i>CYP3A5</i> polymorphisms after tacrolimus initiation. by Maizumi Furuse (10688237)

“…Clinical response was defined as a partial Mayo score reduction of ≥2 points accompanied by a decrease of at least 30% from baseline and a decrease in the rectal bleeding subscore of ≥1 or an absolute rectal bleeding subscore of 0 or 1. …”

S7 Table - by Richard A. Stone (6852653)