Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Here, we reported a novel compound corallorazine D from <i>Nocardiopsis</i> sp. …”

p62 associated with EBI3 in early stage of chondrogenesis. by Tong Zhang (103827)

Stress-sensitive antidepressant-like effects of ketamine in the mouse forced swim test by Paul J. Fitzgerald (3239337)

“…This combination of fast action and a therapeutic effect that lasts far beyond the drug’s half-life points to a unique mechanism of action. …”

Growth curve of a representative patient. by Dalit Modan-Moses (307368)

Oligodendrocyte Kpna expression alters with differentiation. by Benjamin M. Laitman (825245)

“…<p><b>(A,B)</b> T3 and CNTF both induce differentiation of OL. …”

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies by Brianna D. Mackie (9212677)

“…Its cell-permeable analogue <b>DC432</b> (IC₅₀ of 54 ± 4 nM) decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells. …”

SCA of a high-conductance channel. by Melisa Gualdron-López (172625)

“…(<b>E</b>) Current traces of a single channel in response to a low-speed linear increase (upper trace) or decrease (lower trace) of the holding potential. …”

Lymphocyte responses to a dose of aldesleukin. by John A. Todd (5933)

“…<p>(A) Average response curves of the absolute change in lymphocyte count across the five dose groups (average baseline lymphocyte count 1.78 × 10⁹/l, SE = 0.08, range 0.95–3.84, <i>n</i> = 39). …”

Long-Term Use of Everolimus in Patients with Tuberous Sclerosis Complex: Final Results from the EXIST-1 Study by David N. Franz (822882)

“…SEGA response rate (primary end point) was defined as the proportion of patients achieving confirmed ≥50% reduction in the sum volume of target SEGA lesions from baseline in the absence of worsening nontarget SEGA lesions, new target SEGA lesions, and new or worsening hydrocephalus. …”

Hyperthermia impedes functional recovery in hypoxic neuronal networks. by Eva J. H. F. Voogd (20460665)

Hypothermia and hyperthermia impair neuronal functioning in normoxia. by Eva J. H. F. Voogd (20460665)

Hypothermia improves functional recovery in hypoxic neuronal networks. by Eva J. H. F. Voogd (20460665)

Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes by Wipawee Wongchana (5367968)

“…A similar impact on IL-10 production was observed when Notch signaling was inhibited with a gamma-secretase inhibitor (GSI). …”

Evaluation of Efficiency of Liposome-Entrapped Iridium(III) Complexes Inhibiting Tumor Growth In Vitro and In Vivo by Huiyan Hu (9376570)

“…In addition, we also found that 3alip, 3blip, and 3clip triggered ferroptosis and autophagy. …”

<i>T</i>. <i>brucei</i> lysates do not severely compromise liver function. by Adriana Temporão (7841300)

Themes and sub-themes. by Maria Wemrell (6065699)

“…In Sweden, a social media group centered on this issue now gathers around 8,700 members. …”

Rotational Periodicity Display of the Tunable Wettability Pattern in a Photoswitch Based on a Response Bilayer Photonic Crystal by Yong Qi (429532)

A structure of single hidden layers. by Zulqurnain Sabir (12269556)

Dinucleotide A/T and G/C patterns. by Sheila M. Reynolds (245934)

“…<p>These figures show the frequency of dinucleotides composed exclusively of A/T (red) and G/C (blue). The <i>H. sapiens</i> patterns show no evidence of bp periodicity, while the <i>S. cerevisiae</i> patterns do, with peaks in the A/T pattern at 13, 24, 36, 47, 58, and 68, and peaks in the C/G pattern at 0, 20, 32, 42, 50, 61, and 72 bp from the dyad. …”

Summary of the effect of maternal immune activation on serotonin and dopamine. by Pei-Tan Hsueh (752475)

“…Moreover, the total number and distribution of tph2-expressing 5-HTergic neurons, and the diameter of the 5-HTergic axon hillocks were decreased at the age of 8 weeks. We concluded that maternal immune activation induced by exposure to a low dose of LPS decreased cerebral 5-HT in parallel with the down-regulation of 5-HT-related genes (tph2 and slc6a4), resulting in anxiety-like behavior in the female offspring.…”