Transforming Small-Molecule Nanoaggregation into Functional Drug Delivery Platforms by JunHyuk Kim (21235657)

“…The IC₅₀ value of <b>Nano-CC1-Acl</b> further decreases to 0.20 ± 0.16 μM in the presence of cysteine, a biothiol. …”

Table_1_A Multiomic Approach to Investigate the Effects of a Weight Loss Program on the Intestinal Health of Overweight Horses.DOCX by Nicola Walshe (10989768)

“…The alpha-diversity of the fecal microbiota in the treatment group showed a significant increase from the start to the end of the study period (p < 0.05); however, there was no significant difference between groups at any sampling point. …”

Effects of Common Polymorphisms rs11614913 in <em>miR-196a2</em> and rs2910164 in <em>miR-146a</em> on Cancer Susceptibility: A Meta-Analysis by Wei Xu (28953)

“…Rs11614913 in <em>miR-196a2</em> and rs2910164 in <em>miR-146a</em> are shown to associate with increased/decreased cancer risk. …”

MiR-29a targets PTEN. by Guangyao Kong (185282)

“…Empty pcDNA3.0 plasmid (200 ng) was used as a negative control. (C) Luciferase reporter gene assay showed that the decreased luciferase activities of PTEN 3′UTR reporter (PTEN 3′UTR-1 or PTEN 3′UTR-2) in HepG2 cells mediated by miR-29a overexpression (200 ng) was rescued by a miR-29a inhibitor in a dose dependent manner (30, 50, and 100 nM). …”

Impact of 5′ nucleotidase disruption on <i>M</i>. <i>bovis</i> growth phenotype in axenic conditions. by Aga E. Gelgie (17661720)

Effects of sialidase treatment on substantia nigra dopamine neurons. by Jay S. Schneider (671374)

“…<p>Sub-acute MPTP treatment (aCSF-MPTP) resulted in significant decreases in the number of tyrosine hydroxylase immunopositive (A.) and Nissl-stained (B.) cells in the substantia nigra pars compacta. …”

Data selection by changes in the firing rate. by Huu Hoang (9188747)

“…<p>A: the histograms of firing rate change by drug treatments (decreased by CBX and increased by PIX) compared to the CON condition. …”

CORT triggered a slow-onset increase in GluN2A/GluN2B ratio. by Yiu Chung Tse (340737)

“…<p>(<b>A</b>) Plots of NMDAR-EPSC amplitude from control and CORT-treated slices against time show decreased EPSC amplitude after sequential application of Ro (1 µM; for 30 min) and a mixture of Ro and a subunit non-selective NMDAR antagonist APV (50 µM; for 10 min). …”

A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate by Geethakumari, Anupriya M

“…Live cell assays revealed a cleavage sequence length-dependent resonance energy transfer, except for the 12× -syn cleavage site, and an increased rate of cleavage and a decreased pharmacological inhibitor efficacy for the Mpro biosensor containing 2× cleavage sequences. …”
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Size and oligomeric form of BteA287. by Chen Guttman (198535)

“…The elution volume of BteA287 combined with the calibration curve (inset) indicates an empirical molecular weight of 68 kDa (black point indicates the elution volume of BteA287 along the curve). …”

Organic Reaction as a Stimulus for Polymer Phase Separation by Masami Naya (4339054)

Targeting hTERT Promoter G‑Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy by Wei Long (411482)

“…Human telomerase reverse transcriptase (hTERT) may have noncanonical functions in transcriptional regulation and metabolic reprogramming in cancer cells, but it is a challenging target. We thus developed small-molecule ligands targeting hTERT promoter G-quadruplex DNA structures (hTERT G4) to downregulate hTERT expression. …”

Developmental patterns of expression of tectal EphA3 and retinal ephrin-As and Tyr-602 phosphorylated-EphA4. by Ana Laura Ortalli (159899)

“…The expression of ephrin-A2 extends along all the retina, presenting a decreasing naso-temporal gradient mainly in the RGCs. …”

Exploration of 2‑((Pyridin-4-ylmethyl)­amino)­nicotinamide Derivatives as Potent Reversal Agents against P‑Glycoprotein-Mediated Multidrug Resistance by Qianqian Qiu (3859564)

“…In-depth studies demonstrated <b>9n</b> has high potency (EC₅₀ = 119.6 ± 6.9 nM), low cytotoxicity, and long duration (>24 h) in reversing adriamycin (ADM) resistance in K562/A02 cells. …”

Flow of premises through the study. by Eleni Mantzari (6991172)

“…The daily volume of wine sold increased during the intervention period by 232 ml (95% CI [13, 487], <i>p</i> = 0.035) or 7.2% (95% CI [0.4%, 14.5%]). Daily revenues decreased by 5.0% (95% CI [9.6%, −0.3%], <i>p</i> = 0.038).…”

Wind speed box plots at observation stations (red) and ERA5 cells (green) at heights of 10m and 100m, respectively. by Weidong Ji (129916)

A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells by V Bhattacharjee (681247)

“…A sublethal dose (50 nM) of the drug was used to model situations of limiting drug availability to PCa tumors in vivo. …”

Data Sheet 1_Pain assessment on a numerical scale with uncertainty intervals: a proof-of-concept simulation study.docx by Markus Huber (317962)

“…Given the broad spectrum of physiological and psychological factors involved in a patient's pain experience, these point estimates entail inherent uncertainty. …”

High-performance thin-layer chromatogram of mouse brain ganglioside distribution in control (Ctl 1, Ctl 2) and experimental (VCS, #8566, #8568) brain tissue. by Jay S. Schneider (671374)

“…Note the increase in GM1 in VCS animals and decreased GD1a, GT1a, GT1b, and GQ1b, in striatal (CD) and hippocampus (HP) samples.…”

Baseline characteristics of the study subjects^a. by Ga Young Lee (1809919)