<i>In Silico</i> Identification and <i>In Vitro</i> and <i>In Vivo</i> Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer Drug by Xi-Nan Shi (765399)

The Efficacy of Hyperbaric Oxygen Therapy on Middle Cerebral Artery Occlusion in Animal Studies: A Meta-Analysis by Yang Xu (178421)

“…Subgroup analysis showed that a maximal neuro-protective effect was reached when HBO was administered immediately after MCAO with an absolute atmospheric pressure (ATA) of 2.0 (50% decrease; 95% CI, 43% -57% decrease; <i>p</i> < 0.0001) and more than 6 hours HBO treatment (53% decrease; 95% CI, 41% -64% decrease; <i>p</i> = 0.0005).…”

Trehalose treatment induced reduced dendritic growth and increased total volume of LAMP1⁺ lysosomes in Purkinje cells <i>ex vivo</i>. by Collin M. MacLeod (17512385)

MCMV infection stimulates mRNA expression of SOCS1 and SOCS3 mRNA in MEFs. by Christine I. Alston (3737545)

The Potential Connectivity of Waterhole Networks and the Effectiveness of a Protected Area under Various Drought Scenarios by Georgina O’Farrill (564895)

“…The Greater Calakmul Region of the Yucatan Peninsula (Mexico) has experienced a 16% decrease in precipitation over the last 50 years, which we hypothesise has affected water resource connectivity. …”

Data_Sheet_1_Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Act... by Sourya Bhattacharya (8441028)

“…A significant decrease in melting temperature (BlaC T_M 60°C, S130A T_M 50°C, and S130G T_M 45°C), kinetic instability at higher temperature, and comparative dynamic instability correlate the fact that resistance to beta-lactam/beta-lactamase inhibitor combinations will likely not arise from the structural alteration of BlaC, therefore establishing confidence that this therapeutic modality can be potentially applied as a part of a successful treatment regimen against M. tuberculosis.…”

Data_Sheet_2_Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Act... by Sourya Bhattacharya (8441028)

“…A significant decrease in melting temperature (BlaC T_M 60°C, S130A T_M 50°C, and S130G T_M 45°C), kinetic instability at higher temperature, and comparative dynamic instability correlate the fact that resistance to beta-lactam/beta-lactamase inhibitor combinations will likely not arise from the structural alteration of BlaC, therefore establishing confidence that this therapeutic modality can be potentially applied as a part of a successful treatment regimen against M. tuberculosis.…”

TRF1 binding is inhibited by a single nucleotide gap in telomeric DNA by Patricia L. Opresko (7493)

“…Substrates (2.5 nM) were incubated alone (−) or together with decreasing concentrations of TRF1 (200, 100, 50 or 25 nM) (lanes 2–5 and 7–10) for 20 min at 4°C in TEL buffer. …”

A combined loss of PAR-2 and matriptase leads to underdevelopment of placental labyrinth. by Roman Szabo (138655)

“…P values: *<0.05, **<0.01, ***<0.001, Student's t-test, two-tailed. Scale bars: (<b>A, B</b>) 50 µm, (<b>C</b>) 100 um, (<b>D, E, F, H</b>) 200 µm, (<b>G, I</b>) 50 µm.…”

Survival of starvation-induced L1 arrest is a function of RIS activity. by Inka Busack (8474334)

“…B) Strong inactivation significantly decreases survival in L1 arrest whereas strong activation prolongs survival (three-parameter logistic fit, see also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010665#pgen.1010665.s012" target="_blank">S1 Table</a>, Fisher’s Exact Test was conducted when 50% of wild-type worms were alive (day 22)). …”

Impact of interventions on attendances and disease spectra based on segmented regression analysis. by Weiqin Liu (8489124)

Infection of mouse macrophages with SG-MCMV, but not UV-inactivated SG-MCMV, stimulates cytokines known to induce SOCS1 and SOCS3. by Christine I. Alston (3737545)

S2 Fig - by Daniel Redondo-Gómez (11881399)

“…Only the 15 top-ranked research areas are shown, decreasingly sorted by the median. Research areas are classified by branches of knowledge and points are colored according to year. …”

S3 Fig - by Daniel Redondo-Gómez (11881399)

“…Only the 15 top-ranked research areas are shown, decreasingly sorted by the median. Research areas are classified by branches of knowledge and points are colored according to year. …”

Boxplot of the log10 transformed expression values for selected GO terms. by Michael Schneider (1806265)

Transmission electron microscopic examination of ultrastructural morphology of mitochondria in microglia. by Li Hu (326656)

Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders by Katrin Linda (4245613)

“…Starting from KANSL1-deficient human induced-pluripotent stem cells, both from KdVS patients and genome-edited lines, we identified SOD1 (superoxide dismutase 1), an antioxidant enzyme, to be significantly decreased, leading to a subsequent increase in oxidative stress and autophagosome accumulation. …”

Cnot4 mediates differentiation into adipocytes from mouse embryonic fibroblasts. by Tomokazu Yamaguchi (8284989)

Zebrafish PGRP5 exhibits differential expression characteristics under different bacterial stimuli. by Xi Li (19208)

Valve closing capability and hemolymph flow analysis. by Christian Meyer (6035)

“…Upon heartbeat hemolymph packages pass ROI1 (located anteriorly to cardiac valves), reaches peak intensity and falls down to a baseline again, indicating hemolymph transport and proper valve luminal closure in control animals and in <i>rab11</i> knockdown, <i>spectrin</i> knockdown and Rab4 overexpression lines (D-H, Scheme in D highlights characteristic timepoints of the pumped dye package passing the ROI, asterisks represent respective points in the oscillogram. …”