Targeting hTERT Promoter G‑Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy by Wei Long (411482)

“…Human telomerase reverse transcriptase (hTERT) may have noncanonical functions in transcriptional regulation and metabolic reprogramming in cancer cells, but it is a challenging target. We thus developed small-molecule ligands targeting hTERT promoter G-quadruplex DNA structures (hTERT G4) to downregulate hTERT expression. …”

C9orf72 and SMCR8 form a stable protein complex. by Janet Ugolino (3359054)

“…Arrow points to C9orf72 and asterisk indicates a cross-reacting band. …”

Developmental patterns of expression of tectal EphA3 and retinal ephrin-As and Tyr-602 phosphorylated-EphA4. by Ana Laura Ortalli (159899)

“…The expression of ephrin-A2 extends along all the retina, presenting a decreasing naso-temporal gradient mainly in the RGCs. …”

Exploration of 2‑((Pyridin-4-ylmethyl)­amino)­nicotinamide Derivatives as Potent Reversal Agents against P‑Glycoprotein-Mediated Multidrug Resistance by Qianqian Qiu (3859564)

“…In-depth studies demonstrated <b>9n</b> has high potency (EC₅₀ = 119.6 ± 6.9 nM), low cytotoxicity, and long duration (>24 h) in reversing adriamycin (ADM) resistance in K562/A02 cells. …”

Schematic depiction of <i>GBA1</i> targeting strategy. by Nicole K. Polinski (10947787)

Flow of premises through the study. by Eleni Mantzari (6991172)

“…The daily volume of wine sold increased during the intervention period by 232 ml (95% CI [13, 487], <i>p</i> = 0.035) or 7.2% (95% CI [0.4%, 14.5%]). Daily revenues decreased by 5.0% (95% CI [9.6%, −0.3%], <i>p</i> = 0.038).…”

Wind speed box plots at observation stations (red) and ERA5 cells (green) at heights of 10m and 100m, respectively. by Weidong Ji (129916)

A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells by V Bhattacharjee (681247)

“…A sublethal dose (50 nM) of the drug was used to model situations of limiting drug availability to PCa tumors in vivo. …”

High-performance thin-layer chromatogram of mouse brain ganglioside distribution in control (Ctl 1, Ctl 2) and experimental (VCS, #8566, #8568) brain tissue. by Jay S. Schneider (671374)

“…Note the increase in GM1 in VCS animals and decreased GD1a, GT1a, GT1b, and GQ1b, in striatal (CD) and hippocampus (HP) samples.…”

Baseline characteristics of the study subjects^a. by Ga Young Lee (1809919)

CgHtz1 levels are reduced under high-iron conditions. by Mahima Sagar Sahu (18555062)

Photomicrographs of DG from control gerbils and during and after infection with <i>Giardia</i>. by Angélica González Maciel (18946369)

Growth and <i>in vitro</i> differentiation of <i>B</i>. <i>cinerea</i> B05.10 (WT) and mutants generated in this study. by Thomas Leisen (9248883)

Visualization of a classified 3D volume. by Amrita Das Gupta (17364749)

Supplementary Material for: Intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage in a 9-year-old girl: A case report by figshare admin karger (2628495)

“…There have been no reports of patients younger than 10 years. We report a case of typical IHAPSH that occurred in a 9-year-old girl in the advanced stages of myopia. …”

The U937 cell line was seeded at 2 x 10⁵ cells per well. by Janani Madhuravasal Krishnan (19736002)

The U937 cell line was seeded at 1 x 10⁵ cells per well. by Janani Madhuravasal Krishnan (19736002)

Colocalization of pDNA with Rab5. by Lisa D. Cervia (3737431)

Pooled testing schema for testing with Hologic Panther Aptima^® and Fusion^® SARS-CoV-2 assays. by Rudolph Park (14070418)

Evaluation of a Single Dose of Ferric Carboxymaltose in Fatigued, Iron-Deficient Women – PREFER a Randomized, Placebo-Controlled Study by Bernard Favrat (105884)

“…Fatigue was reduced in 65.3% (FCM) and 52.7% (placebo) of patients (OR 1.68, 95%CI 1.05–2.70; p = 0.03). A 50% reduction of PFS score was achieved in 33.3% FCM- vs. 16.4% placebo-treated patients (p<0.001). …”