Image_1_Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following... by Shardulendra Prasad Sherchand (13108779)

“…Therefore, we first optimized an in vitro assay that quantifies recombinant Gmd lysis of the M. luteus cell wall and used it to demonstrate the 50% neutralizing concentration (NC₅₀) of a humanized anti-Gmd mAb (TPH-101) to be ~15.6 μg/ml. …”

Image_3_Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following... by Shardulendra Prasad Sherchand (13108779)

“…Therefore, we first optimized an in vitro assay that quantifies recombinant Gmd lysis of the M. luteus cell wall and used it to demonstrate the 50% neutralizing concentration (NC₅₀) of a humanized anti-Gmd mAb (TPH-101) to be ~15.6 μg/ml. …”

Image_2_Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following... by Shardulendra Prasad Sherchand (13108779)

“…Therefore, we first optimized an in vitro assay that quantifies recombinant Gmd lysis of the M. luteus cell wall and used it to demonstrate the 50% neutralizing concentration (NC₅₀) of a humanized anti-Gmd mAb (TPH-101) to be ~15.6 μg/ml. …”

Longitudinal phenotypic study of late-onset retinal degeneration due to a founder variant c.562C>A p.(Pro188Thr) in the <i>C1QTNF5</i> gene by Julie De Zaeytijd (3633118)

“…</p> <p><b>Results</b>: Best-corrected visual acuity (BCVA) and visual fields were maintained up to 50 to 55 years (n = 8), with a gradual decline, but conservation of functional central vision between 55 to 65 years (n = 15), followed by a steep decrease in overall visual function beyond 65 years (n = 9). …”

KatN is crucial for the survival of EHEC in macrophages. by Baoshan Wan (3833551)

“…All graphs displayed relative mean ± SD of at least three independent experiments. ***, P<0.001, ANOVA analysis. …”

Activation of the <i>PC3</i> Transgene Accelerates the Differentiation of 1–5-d-Old Adult-Generated Dentate Gyrus Stem and Progenitor Cells by Stefano Farioli-Vecchioli (256006)

“…</p> <p>(B) The number of putative stem cells (type-1; BrdU/GFAP/nestin-positive) decreased about 50% in mice with activated <i>PC3</i> transgene.…”

ATF4 knockdown in the ADRP retinas reduces overall ER stress response (N = 4). by Yogesh Bhootada (408443)

“…The T17M ATF4^+/- retinas were the only group with a significant decrease in peIF2a (P<0.01 as compared to T17M retinas) and increased GADD34 protein levels (<i>P</i><0.05 for all groups). …”

UTX-1 is required for VPA action in <i>C. elegans</i> embryos and in human cells. by Rakel Brendsdal Forthun (121022)

“…<p><b>A</b>) Two <i>UTX</i> wild type cell lines (MV4-11 and NB4) as well as the <i>UTX</i> mutant cell line THP-1 were treated with 1 mM VPA for 48 hours and analyzed for H3K27me3 and H2BK120ac expression. The mean intensity on one representative Western blot was calculated and normalized to beta-actin. …”

OxLDL affects EPC neovascularization <i>in vivo</i>. by Feng-Yen Lin (143413)

“…Inclusion of 5 μg/mL of oxLDL in the gel significantly increased the formation of vessel-like structures, and LOX-1 blocking antibody, SP600125, and SB203580 against the increased capacity observed in the gel containing 5 μg/mL of oxLDL alone. In contrast, 50 μg/mL of oxLDL in the gel significantly decreased the formation of vessel-like structures, and LOX-1 blocking antibody, DPI, and APO improved the decreased capacity observed in the gel containing 50 μg/mL of oxLDL alone. …”

Cerebral Synaptosomal Purinergic Receptors were Downregulated in the MIA Model and Restored to Normal by Antipurinergic Therapy. by Robert K. Naviaux (256148)

“…(B) P2Y2 receptor expression was decreased by over 50% by gestational poly(IC) exposure and normalized by suramin treatment (Sal-Sal = 100+/−7.3%; Sal-Sur = 62+/−4.6%; PIC-Sal = 48+/−4.7%; PIC-Sur = 84+/−4.7%; one-way ANOVA F(3,12) = 18.1; p<0.0001; n = 4–5 males per group). …”

Human Marfan and Marfan-like Syndrome associated mutations lead to altered trafficking of the Type II TGFβ receptor in <i>Caenorhabditis elegans</i> - Fig 3 by Jing Lin (50818)

Characterization of the sexual development of deletion mutants for spore-enriched proteins. by Mingwei Huang (788799)

“…Data represent four individual experiments and are shown as mean ± standard deviation (SD). Scale bars, 10μm (100x magnification). …”

Type 2 diabetes and COVID-19 related mortality in the critical care setting: A national cohort study in England, March-July 2020 by John M. Dennis (8929895)

“…The relative mortality risk associated with type 2 diabetes decreased with increasing age (age 18-49 aHR 1.50 [95%CI 1.05;2.15]; age 50-64 1.29 [1.10;1.51]; age 65 or greater 1.18 [1.09;1.29], p-value for age:type 2 diabetes interaction 0.002).…”

The absence of a homeostatic rebound following starvation is independent of starvation duration. by Elizabeth B. Brown (4582978)

DataSheet_1_Impacts of coral bleaching on reef fish abundance, biomass and assemblage structure at remote Aldabra Atoll, Seychelles: insights from two survey methods.zip by Anna Koester (11805572)

“…Introduction<p>Coral bleaching immediately impacts the reef benthos, but effects on fish communities are less well understood because they are often delayed and confounded by anthropogenic interactions.</p>Methods<p>We assessed changes in fish abundance, biomass and community composition before and after the 2015/16 coral bleaching event at Aldabra Atoll, Seychelles, where local human impacts are minimal, but reefs suffered 50% bleaching-induced coral mortality. …”

Time courses of choice probabilities after sequence onset in three regions of the auditory forebrain. by Elena Selezneva (4537447)

“…<p>(A) The thick lines show mean CPs of 239 multiunits recorded in RAC. The thin lines show mean CPs of 82 multiunits recorded in RAC whose firing rate slowly decreased during the waiting period (cp. …”

Programmed Cell Death Progresses Differentially in Epidermal and Mesophyll Cells of Lily Petals by Hiroko Mochizuki-Kawai (830866)

<em>Nigella sativa</em> (Black Cumin) Seed Extract Alleviates Symptoms of Allergic Diarrhea in Mice, Involving Opioid Receptors by Swantje C. Duncker (154707)

“…<em>N. sativa</em> seed extract, thymoquinone, and U50'488 also decreased intestinal mast cell numbers and plasma mouse mast cell protease-1 (MMCP-1). …”

DAF-16 is required for the longevity of <i>clk-1</i>, <i>isp-1</i> and <i>daf-2</i> worms. by Megan M. Senchuk (4925752)

Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols by Yuh Shiwa (512008)

“…We then considered cell-type composition as a possible cause of the observed bias in DNA methylation profiles and found that the bias associated with the cold storage condition was largely decreased (λ_adjusted = 1.14) by taking into account a cell-type composition variable. …”