Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Pain duration dependent decrease in cognitive performance. by Marijtje L. A. Jongsma (208906)

“…For those test where an increase in test score indicated a decrease in performance, the inverse of the raw scores was taken. …”

All data points from S1 to S5 Figs as well as the supplementary method table. by Sara Hijazi (21656615)

Calculation of the Jacobian matrix from different assumptions of the linearization point and the modification of the Jacobian matrix by a subset. by Rongqing Chen (249906)

sC5b-9 patients decrease in patients treated with mycophenolate mofetil. by Joshua M. Thurman (517193)

“…When analyzed separately based upon treatment, the decrease in sC5b-9 levels was due to a decrease in patients treated with mycophenolate mofetil (P < 0.001 by linear regression; n = 12 for all time-points). …”

Growth curves (A, strain AWRI R2 (A); B, strain BH8 (B); C, strain Freddo (F)) and accumulated fermentation system mass loss(D, strain A; E, strain B; F, strain F) of <i>S</i>. <i>... by Xiang-yu Sun (748032)

Raincloud plots with median, quartile, density and individual data points for CV%’s of the DJ metrics across the three time-points analyzed. by Nicolas M. Philipp (13272198)

Mitochondrial protein acetylation correlates with a decrease in sirtuin 3 levels. by Mercedes García-Roche (6459200)

Increased expression of Fz5 receptor matched with a decrease in NeuN immunoreactivity at 16w. by Carlos González-Fernández (2794207)

Decreased splicing efficiency in DENV infected cells. by Federico A. De Maio (3091644)

“…On the lower panel, increase or decrease retention of introns for each time point is shown.…”

Binding mode of clavulanic acid with active site residues of SHV wt at different time intervals (a) binding of ca at 0 ns (b) binding of ca at 2 ns (c) binding of ca at 5 ns (d) bi... by Mohd Hassan Baig (441304)

Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Experimental effect of the “new baby wellness” (versus “home visiting”) label on Black parents’ interest in a newborn home visit program is partially mediated by a decrease in trus... by Jane Leer (20649035)

Effects of specific anti-miRs for the five miRNAss on the IC50 of cisplatin (A) and paclitaxel (B) in Hec1A cells. by Taek Sang Lee (494682)

Predicted lowest-free energy structures of the region surrounding the AUG start codon (blue box) in wild-type and in mutant <i>proA*</i> transcripts in which synonymous mutations i... by JohnCarlo Kristofich (5687573)

Households, population and nets surveyed across time points. by Job Oyweri (22041452)

100P homozygous mice show overall decrease in proportions of PV-expressing cells in the P21 neocortex. by Malgorzata Borkowska (3166719)

Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression by Leah E. Worton (457030)

“…Muscle <i>miR-1</i> and <i>miR-133a/b</i> levels were decreased at these time points, whereas a dose-responsive increase in <i>miR-206</i> expression at day 14 was observed. …”

Temporal distributions of inscriptions and occupations using uniform 50-years-long timeblocks. by Vojtěch Kaše (6156971)