Trends in Glucose Lowering Drug Utilization, Glycemic Control, and Severe Hypoglycemia in Adults with Diabetes in Hong Kong 2002-2016 by Aimin Yang (393426)

“…The proportion of patients with HbA1c of 6.0-7.0% (42-to-53 mmol/mol) increased from 28.6% to 43.4% while SH rate declined from 4.2 per 100-person-years to 1.3 per 100-person-years. The main improvement in HbA1c occurred between 2007 and 2014, decreasing from mean (SD) 7.6 (1.6)% (59.5 [19.0] mmol/mol) to 7.2 (1.7)% (54.8 [18.9] mmol/mol) (p<0.001). …”

<i>Ezh2^fl/fl:Nkx2.5-cre+</i> mice exhibited hypoplastic endocardial cushions. by Li Chen (5749)

“…<b>C & D</b>, 20× magnification; <b>C′–D″</b>, 40× magnification. Scale bar, 100 µm. <b>G</b> shows that the number of Ki67⁺ cells was significantly decreased in <i>Ezh2-cKO</i> hearts relative to the control. …”

Genetic ablation of <i>C1ql1</i>-expressing OPCs prevents myelination in the forebrain without affecting axogenesis. by Shayan Moghimyfiroozabad (19066182)

“…Data are represented as mean ± SEM. <i>C1ql1</i>^<i>wt</i><i>; Sox10</i>^<i>DTA</i>: <i>n</i> = 5 animals. …”

The exocyst is required for cell cycle progression in trypanosomes. by Cordula M. Boehm (3689848)

“…Sec15::RNAi cells have a ∼50% decrease to Sec15::HA 48h post induction, whilst expression of Exo99 remains stable, and <i>vice versa</i>. …”

Timing of production of neurons and glia in rosette cultures. by Elsa Abranches (261932)

“…A decrease in neuronal production is observed at day 16, concomitant with an increase of glial cells. …”

Effects of <i>in vitro</i> treatment with fadrozole on prolactin-positive cells. by María José García Barrado (590761)

“…Scale bar: a,b,c: 50 µm. d) Plot showing the decrease in cellular area at the different time-points assayed; from 3 to 12 hours of treatment with testosterone and fadrozole a significant decrease (*p<0.01) was observed. e) The percentage of prolactin-positive cells decreases as from 3 to 12 hours of treatment with testosterone and fadrozole (*p<0.01). f) The percentage of PCNA- and prolactin-positive cells, out of the total number of prolactin-positive cells, decreases significantly from 1 to 12 hours of treatment with testosterone and fadrozole (*p<0.01).…”

Effects of time on <i>ex vivo</i> spectral imaging. by Torre M. Bydlon (295015)

“…<p>50x bicubic interpolated images of a negative and positive margin from different patients, where the “initial” images of the margins were imaged at approximately the same time points post-excision. …”

<i>mir-80</i>(Δ) exhibits multiple features of healthy aging. by Mehul Vora (94793)

“…<i>mir-80</i>(Δ) has low intestinal age pigment levels compared to wild type during late adult life (day 11). We grew age-synchronized WT (black), <i>mir-80</i>(Δ) (red), and <i>mir-80</i>(Δ); Ex[P<i>mir-80(+)</i>] (grey) under standard conditions (20°C, on <i>E. coli</i> OP50-1) and scored animals for age pigment levels using a fluorimeter (n = 100 per strain/trial; day 11, as counted from the hatch; <i>mir-80</i>(Δ) is <i>nDf53; mir-80(+)</i> rescue transgene is <i>nEx1457 </i><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003737#pgen.1003737-AlvarezSaavedra1" target="_blank">[18]</a>). …”

Logistic growth in density dependent populations. by Mark Bowler (332184)

Impact of hematocrit on vasodynamics. by William Davis Haselden (9175156)

Lysolecithin-induced endogenous progenitor cell recruitment is strongly reduced in mice lacking Reelin signaling. by Sandrine Courtès (219584)

“…C, D: Quantification of BrdU-positive SVZ-derived cells within the lesion site showing a significant decrease in cell recruitment in mice lacking the Dab1 adaptor required for Reelin signaling (C) as well as in Wt mice treated with Reelin blocking antibody CR50 (D). …”

<i>Bicyclus anynana eyeless</i> sequences and the primers used in the RT-PCR experiments. by Mainak Das Gupta (769404)

Bleaching <i>Isopora palifera</i> with menthol. by Jih-Terng Wang (305733)

“…<p>(A) Decrease in the <i>Symbiodinium</i> density in treated coral with different menthol concentrations; (B) correlation between the menthol concentration and the time for 50% coral bleaching.…”

Comparisons of the Efficacy of Alpha Glucosidase Inhibitors on Type 2 Diabetes Patients between Asian and Caucasian by Xiaoling Cai (319173)

“…When AGI treatment was compared with placebo, a significant difference in HbA1c decline from baseline favoring AGI treatment was found in Asian (weighted mean difference (WMD), −0.50%; 95% CI, −0.66% to −0.34%) and in Caucasian a significant difference in HbA1c decline favoring AGI treatment was also found (WMD, −0.68%; 95% CI, −0.76% to −0.60%). …”

Influence of <i>CCL3L1-CCR5</i> GRG status on vaccine efficacy. by Hemant Kulkarni (64613)

“…The model is for a preventive vaccine that has a true efficacy of 50%. …”

Protein structure prediction by all-atom free-energy refinement-2 by Abhinav Verma (25115)

“…Shaded bars indicate indecisive simulations (see text), where there was no 'largest cluster' in the top 50 decoys. We note that there is only one genuine prediction failure for the high-quality decoy sets. …”

Pharmacological blockade of K_ATP channels negates the hippocampal synaptic and neuronal protection afforded by ketones. by Do Young Kim (131974)

“…Asterisks denote significant differences between experimental groups and the control at a specific time-point (*** <i>p</i> < 0.001). The dotted line indicates the mean PS amplitude of the control group. …”

Characterization of hADRB1 and hADRB2 after trace amine challenge. by Gunnar Kleinau (103422)

“…TYR shows no agonistic effect on hADRB1 (p<0.05) and hADRB2 (p<0.01), but acts as an allosteric antagonist on hADRB1/2, indicated by a decreased maximum of stimulation (p<0.05) with comparable EC₅₀ values. …”

Comparison between empirical data and simulation results of FSIR and SIR models. by Ling Feng (283711)

“…<p>In the simulation, the total number of nodes is <i>N</i> = 100,000. The degree distribution is chosen at <i>P</i>(<i>k</i>) ∼ <i>k</i>^−2.5, <i>k</i>_<i>min</i> = 20 and ⟨<i>k</i>⟩ ≈ 50. …”

Antepartum fibrinogen concentration as a predictor of bleeding complications by Laura E. Dodge (7875416)

“…For every 100-mg/dL decrease in fibrinogen, the odds of a bleeding complication increased 1.63 times (95% confidence interval: 1.48–1.80). …”