Image_3_Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockou... by Guang Yang (154978)

“…Furthermore, primary microglia were obtained from neonatal Sprague-Dawley rats and pretreated with or without GZFL (50 μg/ml) for 1 h in the absence or presence of lipopolysaccharide (LPS) (100 ng/ml) stimulation to speculate whether the underlying mechanism of GZFL’s anti-inflammatory potential was closely associated with Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway. …”

Image_1_Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockou... by Guang Yang (154978)

“…Furthermore, primary microglia were obtained from neonatal Sprague-Dawley rats and pretreated with or without GZFL (50 μg/ml) for 1 h in the absence or presence of lipopolysaccharide (LPS) (100 ng/ml) stimulation to speculate whether the underlying mechanism of GZFL’s anti-inflammatory potential was closely associated with Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway. …”

Effects of microbiota-driven therapy on inflammatory responses in elderly individuals: A systematic review and meta-analysis by Hua Qu (618802)

“…Compared with placebo, microbiota-driven therapy did not decrease the levels of tumor necrosis factor-α (SMD, -0.24; 95% CI, -0.69 to 0.21; p = 0.30; I² = 82.7%), interleukin-6 (SMD, -0.13; 95% CI, -0.74 to 0.49; p = 0.69; I² = 90.7%) and interleukin-10 (SMD, 1.00; 95% CI, -0.15 to 2.15; p = 0.09; I² = 96.3%). …”

The ROP2-RIC4 pathway inhibits PIN1 endocytosis through the promotion of the accumulation of cortical actin filaments. by Shingo Nagawa (173932)

“…Application of Latrunculin B (100 nM, LatB) induced uptake of FM1-43 into small vesicles in <i>RIC4 OX</i> cells. …”

FoxO1a is induced by CD81 clustering, concurrent with deactivation of Akt. by Kuanyin K. Lin (200312)

“…Positive nuclear correlation in the single cell images was assigned when the similarity score was more than 1 (more than 100 cells were acquired for each analysis, <i>n</i> = 2 per group of treatment; mean values ± SD are shown, *<i>p</i><0.05). …”

Data_Sheet_1_Effect of intravenous vitamin C on adult septic patients: a systematic review and meta-analysis.zip by Huoyan Liang (8858609)

“…IVVC had a trend to decrease the mortality of septic patients (RR, 0.83; 95% CI, 0.69–1.00; I² = 33%) but did not affect septic shock patients (RR, 1.01; 95% CI, 0.85–1.21; I² = 18%). …”

Image_1_Finerenone in type 2 diabetes and renal outcomes: A random-effects model meta-analysis.jpeg by Samit Ghosal (6174653)

“…The hazard ratio was used as the effect size for the renal composite, while the standardized mean difference (SMD) was used to estimate the effect size of eGFR decline and reduction in the urine albumin creatinine ratio (UACR). …”

Data_Sheet_1_Effect of intravenous vitamin C on adult septic patients: a systematic review and meta-analysis.zip by Huoyan Liang (8858609)

“…IVVC had a trend to decrease the mortality of septic patients (RR, 0.83; 95% CI, 0.69–1.00; I² = 33%) but did not affect septic shock patients (RR, 1.01; 95% CI, 0.85–1.21; I² = 18%). …”

Neuronal migration defects in the cortex and hippocampus of <i>R402H/+; Emx1-cre</i> mice. by Ines Leca (9592316)

“…Scale bars show 1000 μm in A, 100 μm in B and 200 μm in E.</p>…”

Table_1_Finerenone in type 2 diabetes and renal outcomes: A random-effects model meta-analysis.docx by Samit Ghosal (6174653)

“…The hazard ratio was used as the effect size for the renal composite, while the standardized mean difference (SMD) was used to estimate the effect size of eGFR decline and reduction in the urine albumin creatinine ratio (UACR). …”

Table2_Protective Role of Mytilus edulis Hydrolysate in Lipopolysaccharide-Galactosamine Acute Liver Injury.XLSX by Eleonora Starikova (10813602)

“…N2-01 decreased Vascular Cell Adhesion Molecule-1 (VCAM-1) expression from 4.648 ± 0.445 to 1.503 ± 0.091 Mean Fluorescence Intensity (MFI) and Interleukin-6 (IL-6) production in activated Human Umbilical Vein Endothelial Cells (HUVECs) from 7.473 ± 0.666 to 2.980 ± 0.130 ng/ml in vitro. …”

Table4_Protective Role of Mytilus edulis Hydrolysate in Lipopolysaccharide-Galactosamine Acute Liver Injury.XLSX by Eleonora Starikova (10813602)

“…N2-01 decreased Vascular Cell Adhesion Molecule-1 (VCAM-1) expression from 4.648 ± 0.445 to 1.503 ± 0.091 Mean Fluorescence Intensity (MFI) and Interleukin-6 (IL-6) production in activated Human Umbilical Vein Endothelial Cells (HUVECs) from 7.473 ± 0.666 to 2.980 ± 0.130 ng/ml in vitro. …”

Table3_Protective Role of Mytilus edulis Hydrolysate in Lipopolysaccharide-Galactosamine Acute Liver Injury.DOCX by Eleonora Starikova (10813602)

“…N2-01 decreased Vascular Cell Adhesion Molecule-1 (VCAM-1) expression from 4.648 ± 0.445 to 1.503 ± 0.091 Mean Fluorescence Intensity (MFI) and Interleukin-6 (IL-6) production in activated Human Umbilical Vein Endothelial Cells (HUVECs) from 7.473 ± 0.666 to 2.980 ± 0.130 ng/ml in vitro. …”

Table1_Protective Role of Mytilus edulis Hydrolysate in Lipopolysaccharide-Galactosamine Acute Liver Injury.XLSX by Eleonora Starikova (10813602)

“…N2-01 decreased Vascular Cell Adhesion Molecule-1 (VCAM-1) expression from 4.648 ± 0.445 to 1.503 ± 0.091 Mean Fluorescence Intensity (MFI) and Interleukin-6 (IL-6) production in activated Human Umbilical Vein Endothelial Cells (HUVECs) from 7.473 ± 0.666 to 2.980 ± 0.130 ng/ml in vitro. …”

Table 1_Effect of cholecalciferol on immune and vascular function in non-diabetic chronic kidney disease.docx by Kajal Kamboj (12769602)

“…</p>Results<p>In total, 62 subjects were studied. The mean age was 44 ± 12 years with 58% men. TH1 cells decreased from 17% (9%, 27%) to 11% (6%, 16%) (p=0.002) and TH2 cells increased from 9% (5%, 16%) to 16% (10%, 27%) (p=0.001) after cholecalciferol treatment. …”

Sensitivity analysis of the Simulink model in <b>Figure 3</b>. by Mark F. Walker (359676)

“…Effect of varying model parameters on the error function of the simulation (the summed squared difference of simulated and actual eye velocities). Similar to <b>a</b> and <b>b</b>, the error function is shown as a percent of the baseline; thus, a value of 50 corresponds to an error magnitude that is 50 times greater. …”

3D reconstruction of oocyte during the SCW. by Nils Klughammer (5978690)

Table_1_Monitoring the Neurotransmitter Response to Glycemic Changes Using an Advanced Magnetic Resonance Spectroscopy Protocol at 7T.DOCX by Young Woo Park (8349177)

“…The protocol was tested in six patients with type 1 diabetes during a clamp study where euglycemic (~100 mg/dL) and hypoglycemic (~50 mg/dL) blood Glc levels were maintained in the scanner. …”

Possible Increase in Serum FABP4 Level Despite Adiposity Reduction by Canagliflozin, an SGLT2 Inhibitor by Masato Furuhashi (85555)

“…Treatment with canagliflozin significantly decreased adiposity and levels of fasting glucose and HbA1c but increased average serum FABP4 level by 10.3% (18.0 ± 1.0 vs. 19.8 ± 1.2 ng/ml, P = 0.008), though elevation of FABP4 level after treatment was observed in 26 (66.7%) out of 39 patients. …”

Replication of mutant FMDVs in BHK–21 cells. by Armando Arias (134798)

“…<b>D</b>, Average number of viral RNA molecules per cell (quantitated both inside the cells and in the culture medium) at 72 hours post–transfection of 2×10⁶ BHK–21 cells with 100 ng of the indicated RNA transcripts. The cells and supernatants were harvested at 72 hours post–transfection, and the number of genomic RNA molecules was calculated by quantitative real–time RT–PCR, as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010735#s4" target="_blank">Materials and Methods</a> (limit of detection 8 viral RNA molecules/cell, indicated as a dashed line). …”