Jatrophane Diterpenoids from <i>Euphorbia glomerulans</i> by Aobulikasimu Hasan (6448166)

“…Several compounds showed different chemoreversal activities and considerably decreased cytotoxicity. Compounds <b>11</b> (IC₅₀ value of 5.0 ± 0.8 μM) and <b>12</b> (IC₅₀ value of 5.2 ± 2.0 μM) possessed MDR reversal activities that were as good as that of verapamil (IC₅₀ value of 4.7 ± 0.6 μM).…”

Jatrophane Diterpenoids from <i>Euphorbia glomerulans</i> by Aobulikasimu Hasan (6448166)

“…Several compounds showed different chemoreversal activities and considerably decreased cytotoxicity. Compounds <b>11</b> (IC₅₀ value of 5.0 ± 0.8 μM) and <b>12</b> (IC₅₀ value of 5.2 ± 2.0 μM) possessed MDR reversal activities that were as good as that of verapamil (IC₅₀ value of 4.7 ± 0.6 μM).…”

Jatrophane Diterpenoids from <i>Euphorbia glomerulans</i> by Aobulikasimu Hasan (6448166)

“…Several compounds showed different chemoreversal activities and considerably decreased cytotoxicity. Compounds <b>11</b> (IC₅₀ value of 5.0 ± 0.8 μM) and <b>12</b> (IC₅₀ value of 5.2 ± 2.0 μM) possessed MDR reversal activities that were as good as that of verapamil (IC₅₀ value of 4.7 ± 0.6 μM).…”

Flowchart of the materials and methods section. by Kamilla N. Alieva (16764721)

Effect of Fzd5 overexpression on neuronal morphology is partially prevented by a JNK inhibitor. by Paula G. Slater (474025)

“…Error bars indicate standard error of the mean of three independent experiments for the treated neurons and five independent experiments for the neurons without treatment.…”

Hybrid stochastic framework predicts efficacy of prophylaxis against HIV: An example with different dolutegravir prophylaxis schemes by Sulav Duwal (152805)

“…Combining the population pharmacokinetics of DTG with the stochastic framework, we predicted that plasma concentrations of 145.18 and 722.23nM prevent 50- and 90% sexual transmissions respectively. …”

Microflow Liquid Chromatography Coupled to Multinozzle Electrospray Ionization for Improved Lipidomics Coverage of 3D Clear Cell Renal Cell Carcinoma by Sergey Girel (6887840)

“…With a runtime of 19 min, similar to our established analytical flow (AF/ESI) lipidomics platform, μF/mnESI produced a 16-fold median increase across 69 deuterated lipid standards. …”

Extended exposure to extracellular adenosine (ADO) causes a dose-dependent reduction in chlamydial development via the A2b adenosine receptor. by Matthew A. Pettengill (256020)

“…(<b>B</b>) HeLa cell knock-downs (KDs) were produced with non-targeted (Control), A2a-targeted (A2a KD) or A2b-targeted (A2b KD) shRNA and levels of target KD verified to be decreased at least 50% by qPCR. …”

Activated CD4+ CD45RO+ memory T-cells decrease secretion of soluble caspase-1 and P2X7R mRNA expression in monocytes leading to a reduced response upon ATP binding. by Vanessa Beynon (153924)

“…<p>a) sCaspase-1 levels in the supernatant of monocytes was measured by ELISA (n = 8). A significant decrease of soluble Caspase-1 in the supernatant of cells co-cultured with activated memory T-cells was observed both in the presence and absence of IFNβ; b) intracellular levels of pro-IL-1β measured with an ELISA specific for the immature precursor of IL-1β showed a significant increase in pro-IL-1β levels in the presence of human activated CD4+CD45RO+ memory T-cells (n = 3), cell lysates from adherent monocytes were obtained after removal of non-adherent T-cells after addition of LPS and prior to incubation with ATP c) the ratio of intracellular pro-IL-1β to released soluble Caspase-1 is significantly increased in the presence of human activated CD4+CD45RO+ memory T-cells (n = 3). d) <i>P2X7R</i> mRNA expression in monocytes cultured overnight with activated CD4+CD45RO+ memory T-cells is decreased with and without addition of exogenous IFNβ (n = 3), mRNA was isolated from adherent monocytes after removal of non-adherent T-cells after addition of LPS and prior to incubation with ATP (Data are shown as means ± SD of duplicate cultures; *p<0.05; **p<0.01 employing repeated measures ANOVA with post-hoc Bonferroni adjustment for multiple comparisons to avoid random correlations); e) Ca²⁺-influx measurement in monocytes cultured with activated human CD4+CD45RO+ memory T-cells in the presence of IFNβ demonstrates the absence of slow sustained Ca²⁺-influx mediated by ATP binding to the purinergic P2X7-receptor (representative of 3 independent experiments); f) Annexin V staining of monocytes coincubated with T-cells and stimulated with LPS was measured by flow cytometry (representative flow cytometry histogram of n = 5).…”

Image_5_Heterogeneity in the isolation of patches may be essential for the action of metacommunity mechanisms.JPEG by Ana I. Borthagaray (14952037)

Effect of elastase injection on <i>Fbln5</i> Cre+cKO mice. by Kathleen Chin (275937)

“…F5^-/-, negative control; Ctl, nonpregnant wild type; PP, 48 h postpartum wild type control indicating decrease in Fbln5. …”

Proportion of participants reporting a COVID-19 test among those reporting test-qualifying symptoms. by Mark S. Graham (4484317)

Concentration of suspended solids (mg /l) in six concentrations of water turbidity. by Javier Manjarrez (531011)

The evolution of the Extra-Metabolic Scholander-Irving model. by Halley B. Hughes (15198112)

Time-course of BCR-ABL and SFK dephosphorylation after treatment with inhibitors. by Adam Obr (541887)

Decreased levels of CIITApIV H3K18ac, H3K27ac and CBP correlate with significantly elevated levels of H3K27me3 in metastatic breast cancer cells. by Agnieszka D. Truax (169208)

Identification of Small Molecules that Disrupt Signaling between ABL and Its Positive Regulator RIN1 by Pamela Y. Ting (713174)

“…The CML cell line K562 was then used to identify five compounds that decrease MAPK1/3 phosphorylation, which we determined to be an indicator of RIN1-dependent ABL signaling. …”

S1 Raw data - by Dao-Cheng Zhou (20314697)

“…However, the association of LE8 with all-cause and disease-specific mortality in the MetS population remains unknown. We aimed to explore these associations in a national prospective cohort study from NHANES 2005–2018.…”

miRNA expression in pooled samples from univentricular heart failure patients. by Sweta Ramachandran (169036)

“…<p>Pooled sera from patients with Ross scores <3, 3–5, and >5 were evaluated for expression of miRNAs previously implicated as biomarkers of HF in adult patients. miR129-5p showed a decrease in expression with increasing Ross score. …”

Experimental tank to follow the predatory behaviors displayed by snake <i>T</i>. <i>melanogaster</i> over the fish <i>X</i>. <i>variata</i>. by Javier Manjarrez (531011)