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11681
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11682
Potential binding regions mapped onto the crystal structure of AIMP3.
Published 2017“…<p>Upper left: Interface I in yellow, including residues Arg<sup>50</sup>, Thr<sup>68</sup>, Lys<sup>75</sup>, Ala<sup>91</sup>, Gln<sup>94</sup>, Gln<sup>95</sup>, Glu<sup>98</sup>, and Asp<sup>119</sup>. …”
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11683
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11684
The stable isotope method applied in this study is sensitive to detect the expected differences in V<sub>PDH</sub>/V<sub>CS</sub> with physiologic alterations in these fluxes, and...
Published 2019“…(D) V<sub>PDH</sub>/V<sub>CS</sub> is increased with inhibition of fatty acid oxidation (etomoxir) or stimulation of PDH (dichloroacetate), and decreased with inhibition of PDH (6,8-bis(benzylthio)octanoic acid). …”
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11685
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11686
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11687
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11688
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11689
Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma
Published 2017“…Rational design, guided by X-ray analysis of several inhibitors bound to human chitotriosidase (hCHIT1), led to the identification of compound <b>7f</b> as a highly potent AMCase inhibitor (IC<sub>50</sub> values of 14 and 19 nM against human and mouse enzyme, respectively) and selective (>150× against mCHIT1) with very good PK properties. …”
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11690
NFAT does not appear to be involved in latent HIV transcription in 5A8 cells.
Published 2013“…<i>B,</i> FACS analysis of LTR-driven GFP reporter activity (<i>y-axis</i>). Values are mean ± SEM from four experiments. Reporter activity remained partially sensitive to CsA inhibition (lanes 6 to 10) but was insensitive to NFAT knockdown (lanes 3 to 5). …”
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11691
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11692
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11693
Cell death and JNK activation in SH-SY5Y cells stimulated with H<sub>2</sub>O<sub>2</sub> overnight or for 3 h.
Published 2013“…<b>D</b>) Cell viability assay was performed employing MTT colorimetric method. A concentration dependent decrease in cell viability is observed following 3 h stimulation with H<sub>2</sub>O<sub>2</sub> (50 mM: ∼30%; 75 mM: ∼50%). …”
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11694
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11695
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11696
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11697
S1 Data -
Published 2024“…Additionally, 12 hours post-treatment, catalase (an antioxidant enzyme) activity decreased 1.5-fold in a dose-dependent manner, while glutathione S-transferase (a detoxification enzyme) activity increased 7.8-fold. …”
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11698
Supplementary Table 1 - Additional PSD Results
Published 2019“…</b>Arrows represent a significant increase (↑) or decrease (↓) in normalized mGluR5 KO spectral power compared to WT controls in the same condition. …”
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11699
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11700
Ablation of <i>PC3/Tis21</i> impairs terminal differentiation of 1- to 5-day-old adult-generated dentate gyrus progenitor cells.
Published 2009“…<p>New stem and progenitor cells (<b>A–D</b>) and post-mitotic neurons (<b>E–I</b>) of 1 to 5 days of age, as detected by incorporation of BrdU after five daily injections in P60 <i>PC3/Tis21</i><sup>+/+</sup> and <i>PC3/Tis21</i><sup>−/−</sup> mice (referred to as Tis21 throughout the figures), were analyzed by the expression of specific markers through multiple-labeling confocal microscopy. …”