Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

<i>C</i>. <i>sinensis</i> enhanced bile duct and liver injury through TLR2 pathway. by Yuru Wang (846969)

WNT7A Regulation by miR-15b in Ovarian Cancer - Fig 5 by James A. MacLean II (2794756)

“…<p>(A) 5-aza-2’-dC treatment induces <i>miR-15b</i> expression (left) and decreases <i>WNT7A</i> expression (right) in OvCa cells. …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. Primary alkylamine derivatives coupled through a <i>p</i>-amido group with a varying methylene chain length (<b>24</b> and <b>25</b>) were functionalized congeners, for subsequent conjugation to carrier or reporter moieties. …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. Primary alkylamine derivatives coupled through a <i>p</i>-amido group with a varying methylene chain length (<b>24</b> and <b>25</b>) were functionalized congeners, for subsequent conjugation to carrier or reporter moieties. …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. Primary alkylamine derivatives coupled through a <i>p</i>-amido group with a varying methylene chain length (<b>24</b> and <b>25</b>) were functionalized congeners, for subsequent conjugation to carrier or reporter moieties. …”

Effect of high-intensity interval training on glycemic control in adults with type 1 diabetes with overweight or obesity: a randomized controlled trial with partial cross-over by Angela S Lee (8996732)

“…In participants who undertook at least 50% of the prescribed HIIT intervention, the HbA1c reduction was significantly greater than control (HIIT -0.64 ± 0.64% (n=9), control -0.14 ± 0.48% (n=15), p=0.04). …”

Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency by Caiping Zhang (6745976)

Rate-limiting enzymes tyrosine hydroxylase (catecholamines) and tryptophan hydroxylase (5-HT) post-stress. by C. Brad Wilson (468614)

“…<p>Tyrosine hydroxylase elevation in the PFC (A) and hippocampus (B) substantiated the findings of elevated levels of NE and DA, while down-regulated tryptophan hydroxylase in the PFC (C) and hippocampus (D) confirmed decreased levels of 5-HT. All data are presented as mean ± SEM. …”

RipE1 undergoes phosphorylation in <i>N. benthamiana</i>, which contributes to protein stability. by Wenjia Yu (9422059)

Heparanase activity in murine (A) and human (B) sepsis. by Lukas Martin (747245)

Heparanase level in murine (A) and human (B) sepsis. by Lukas Martin (747245)

MiR-512-5p is down-regulated in in telomerase positive HNSCC cell lines. by Jun Li (6494)

“…(B) qRT-PCR analysis of the expression levels of miR-512-5p in various telomerase status cell lines. All data are shown as mean±SD. …”

Effect of different nitrate levels on spinach. by Kangning Han (12001445)

“…This study aimed to elucidate the regulatory mechanisms of nitrate stress tolerance in spinach (<i>Spinacia oleracea</i> L.). We studied the effects of exogenous application of 15 (control), 50, 100, 150, 200, and 250 mM NO₃^- on spinach growth, physiology, and photosynthesis. …”

RipE1 phosphorylation and NbUCH-mediated deubiquitination are independent mechanisms leading to RipE1 stability. by Wenjia Yu (9422059)

Urine metabolomics in RM and CM mouse models. by Amrita K. Cheema (515119)

CiLV-C p29 acts as an RNA-binding protein and interacts with eukaryotic initiation factor 4A (eIF4A). by Mikhail Oliveira Leastro (5736329)

“…Samples were loaded at different concentrations (1:4 dilution factor), starting from 5μL and decreasing to 1.25 μL. The left panel shows a Coomassie blue-stained gel, while the right panel shows results from northwestern blot analysis. …”

Genetic deletion of P2rx7 leads to the alteration of NA and 5-HT levels (A, B), elevation of³H-Citalopram binding sites and 5-HT uptake (C) in the mouse hippocampus. by Cecilia Csölle (425362)

“…NA and 5-HT levels are expressed as pmol/mg protein. Data are given as the mean ± SEM of 13–22 experiments. …”

Effects of TrxR1 knockdown by siRNA in SH-SY5Y cells. by Zhong-Wei Qu (291559)

“…<p><i>A,</i> Successful transfection of SH-SY5Y cells with a fluorescein-labeled scrambled-control siRNA. …”

Result of whole-mount <i>in situ</i> hybridization at 48 hpf. by Yali Ge (417371)