<i>In vivo</i> HDL protects the heart from IR injury via STAT3 activation. by Sarah Pedretti (703288)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Brain regions (ROIs) showing significantly increased ReHo in StD group (decreased ReHo in NC) (two sample <i>t</i>-test, thresholded at <i>p</i><0.005 with an extent threshold 5 co... by Zhenling Ma (290924)

Image 5_Efficacy and safety of therapeutic exercise for primary dysmenorrhea: a systematic review and meta-analysis.jpeg by Yi Xiang (511856)

Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise - Fig 1 by Anders Gudiksen (3165363)

Nrf2 is necessary for optimal PMN migration toward CXCL12 and CXCL2 without regulating receptors expression. by Doumet Georges Helou (7255823)

Trade-offs between suppressing cheaters and decreasing the time to stochastic clearance of a pure producer population, as controlled by <i>K</i>_<i>a</i>, are present for... by Alexander S. Moffett (8250291)

Semi-log plot of the total number of medals obtained by countries at Beijing (BJG) and London (LDN) recent Summer Olympic Games, as ranked according to their decreasing “order of i... by Marcel Ausloos (748325)

Semi-log plot of the number of Gold medals obtained by countries at Beijing (BJG) and London (LDN) recent Summer Olympic Games, as ranked according to their decreasing “order of im... by Marcel Ausloos (748325)

Fatal autoimmune disorder in mice with T_reg cell–specific disruption of <i>miR-142</i>. by Wei-Le Wang (133402)

<i>miR-142</i> ablation impairs suppressive function and homeostasis of T_reg cells. by Wei-Le Wang (133402)

Histological findings of adult WT and <i>Gli1</i>^+/− mice. by Yoshiaki Kitaura (644233)

Relationship between drug effects on animations task performance and emotion recognition performance. by Bianca A. Schuster (18824561)

Loss of RBM-26 causes mitochondria dysfunction in PLM. by Tamjid A. Chowdhury (14149846)

<i>Yap (5SA)</i> mRNA-injected embryos exhibit dramatic downregulation of retinal photoreceptor genes. by Yoichi Asaoka (564124)

“…<p>(A) The top five GO categories for genes downregulated by over 4.0-fold in <i>yap (5SA)</i>-expressing embryos at 48 hpf as determined by microarray analysis. …”

Items. by Samuel W. Terman (13584382)

“…<div><p>Epilepsy is a common, serious condition. Fortunately, seizure risk decreases with increasing seizure-free time on antiseizure medications (ASMs). …”

Survey feedback. by Samuel W. Terman (13584382)

“…<div><p>Epilepsy is a common, serious condition. Fortunately, seizure risk decreases with increasing seizure-free time on antiseizure medications (ASMs). …”