Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

Subjects:

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

Subjects:

How the variation in inhibitor concentration throughout one day affects the value of IC₅₀/(IC₅₀ + [R]) for different Abl1 inhibitors. by J. Roadnight Sheehan (20141887)

Pim overexpression increases and Pim inhibition by DHPCC-9 decreases growth of orthotopic prostate xenografts. by Niina M. Santio (279874)

Complete data. by Jan Víteček (11434774)

“…A tenfold decrease or increase in concentration induced only a 2-fold decrease or increase in clot degradation. …”

Fig 4 - by Jan Víteček (11434774)

“…A tenfold decrease or increase in concentration induced only a 2-fold decrease or increase in clot degradation. …”

Aged blood factors decrease cellular responses associated with delayed gingival wound repair by María Paz Saldías (4430032)

“…<div><p>Aging is a gradual biological process characterized by a decrease in cell and organism functions. …”

Transcriptional and translational markers of syncytialization and biochemical differentiation are significantly decreased by rotenone. by O’Llenecia S. Walker (8486163)

TUDCA decreases ER stress in HOX neonatal rat lungs. by Kirkwood A. Pritchard Jr. (13449794)

“…<p>(<b>A</b>) The expression levels of ER stress markers (P-PERK 0.6±0.1-fold, p<0.001, n = 5; PERK 0.7±0.1-fold, p = 0.00364, n = 5; P-IRE1α 0.6±0.0-fold, p<0.001, n = 5; IRE1α 0.6±0.1-fold, p<0.001, n = 5; GRP78 0.8±0.1-fold, p<0.001, n = 5; cleaved ATF6 0.1±0.0-fold, p<0.001, n = 5; spliced XBP1 0.3±0.0-fold, p<0.001, n = 5; 2 males and 3 females) are all decreased while the N-glycosylated VEGFR2 is increased (3.5±0.2-fold, p<0.001, n = 5) in HOX neonatal lungs at P10 indicating TUDCA can attenuate hyperoxia-induced ER stress. …”

<i>Myotis rufoniger</i> genome sequence and analyses: <i>M</i>. <i>rufoniger’s</i> genomic feature and the decreasing effective population size of <i>Myotis</i> bats by Youngjune Bhak (3511349)

“…<i>rufoniger</i>. We generated 124 Gb of short-read DNA sequences with an estimated genome size of 1.88 Gb at a sequencing depth of 66× fold. …”

RDV and EIDD2801 EC₅₀ and fold-change in VeroE6-ACE2-TMPRSS2. by Agnieszka M. Szemiel (10196243)

Hepatic Expression of Detoxification Enzymes Is Decreased in Human Obstructive Cholestasis Due to Gallstone Biliary Obstruction by Jin Chai (183630)

“…</p><p>Conclusions</p><p>The levels of hepatic detoxification enzymes were significantly decreased in human obstructive cholestasis, and these decreases were positively associated with a marked reduction of FXR levels. …”

Predictions of random forests (RF), gradient boosting machines (GBM), and neural networks (NN) trained on 12 covariates chosen using subjective feature selection. by Dennis Ochola (11626912)

Predictions of random forests (RF), gradient boosting machines (GBM), and neural networks (NN) trained on 17 covariates selected after recursive feature selection. by Dennis Ochola (11626912)

Decrease of 4 Asp isomers at 70°C. by Kenzo Aki (386666)

“…<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058515#pone-0058515-g007" target="_blank">Figure 7a:</a> decrease of L-α-Asp with incubation of T6-Lα peptide at 70°C. …”

miR-100 decreases tumor size. by Bahauddeen M. Alrfaei (484859)

Demonstration of the effects of decreased size at metamorphosis on amphibians by Tyrone B. Hayes (29098)

COG annotation of differentially abundant proteins of three genotypes of <i>Lolium perenne</i> (fold increase>1.5, fold decrease<0.5, <i>P</i> < 0.05). by Fatemeh Raeisi Vanani (8991491)

Inactivation of one allele of FT5. by Sophia Bigot (16469992)

PTH decreased cell apoptosis in a Flt-3L expanded population. by Flavia Q. Pirih (360515)