Image 1_COP1 drives renal cell carcinoma progression by targeting ACSL4 for ubiquitin-mediated degradation and inhibiting ferroptosis.tif by Yuxiao Zheng (8334027)

“…Functional studies demonstrated that COP1 overexpression markedly increased RCC cell proliferation by 65% (786-O) and 58% (ACHN) (p < 0.001) and enhanced migration/invasion (p < 0.01), while COP1 knockdown suppressed these malignant phenotypes by 40–50%. Mechanistically, COP1 directly bound ACSL4 and promoted its K48-linked ubiquitination, reducing ACSL4 protein stability by 70% (p < 0.001) and suppressing ferroptosis, as evidenced by decreased lipid ROS levels (p < 0.01) and reversal of ferroptosis inhibition by ferrostatin-1. …”

Image_1_From Understory to Canopy: In situ Behavior of Neotropical Forest Katydids in Response to Bat Echolocation Calls.TIFF by Laurel B. Symes (3241299)

“…To illuminate how insects respond to bats in nature, we studied how calling behavior changed when katydids experienced echolocation calls in a Neotropical forest. …”

Data_Sheet_1_From Understory to Canopy: In situ Behavior of Neotropical Forest Katydids in Response to Bat Echolocation Calls.PDF by Laurel B. Symes (3241299)

“…To illuminate how insects respond to bats in nature, we studied how calling behavior changed when katydids experienced echolocation calls in a Neotropical forest. …”

Optically Stimulated Luminescence (OSL) age and supporting data for sample JQ200-OSL1. by Rémy Crassard (118552)

“…Of the 2951 grains rejected, 2640 were discarded because the OSL signals were too dim to discern above background, and 311 were rejected on the basis of feldspar contamination, high ‘recuperation’ or a poor ‘recycling ratio’. The weighted mean D_e was calculated for the remaining grains using the Central Age Model <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068061#pone.0068061-Galbraith1" target="_blank">[70]</a>, after discarding three values (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068061#pone-0068061-g005" target="_blank">Figure 5</a>) that differ from the weighted mean by >2σ and have normalised median absolute deviations of >1.5 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068061#pone.0068061-Powell1" target="_blank">[126]</a>. …”

DataSheet_1_Associations of chest X-ray trajectories, smoking, and the risk of lung cancer in two population-based cohort studies.docx by Ya Liu (205636)

“…If participants gained positive CXR, LC incidence risk significantly climbed to 22.04(15.37–31.60) and 71.97(48.82–106.09) for ever and current smokers, while LC mortality risk climbed to 11.90(8.58–16.50) and 38.92(27.04–56.02). CXR_LP was associated with decreased LC risk. …”

Image1_Chronic Oral Administration of Mineral Oil Compared With Corn Oil: Effects on Gut Permeability and Plasma Inflammatory and Lipid Biomarkers.TIF by Elsbet J. Pieterman (7321421)

“…Mean plasma lipopolysaccharide-binding protein levels were raised with mineral versus corn oil 30 µL/day (12 weeks: 5.8 versus 4.4 μg/ml, p = 0.03; 16 weeks: 5.8 versus 4.5 μg/ml, p = 0.09), indicating increased intestinal bacterial endotoxin absorption and potential pro-inflammatory effects. …”

DataSheet1_Chronic Oral Administration of Mineral Oil Compared With Corn Oil: Effects on Gut Permeability and Plasma Inflammatory and Lipid Biomarkers.docx by Elsbet J. Pieterman (7321421)

“…Mean plasma lipopolysaccharide-binding protein levels were raised with mineral versus corn oil 30 µL/day (12 weeks: 5.8 versus 4.4 μg/ml, p = 0.03; 16 weeks: 5.8 versus 4.5 μg/ml, p = 0.09), indicating increased intestinal bacterial endotoxin absorption and potential pro-inflammatory effects. …”

Use of Targeted Exome Sequencing in Genetic Diagnosis of Chinese Familial Hypercholesterolemia by Wen-Feng Wu (550015)

“…After 6 months of therapy, the LDL-C level of the proband decreased by more than 50% and the LDL-C of the other family members with heterozygous mutation also reduced to normal. …”

Depletion of aquaglyceroporins reduces parasite load in <i>P</i>. <i>berghei</i> infected HuH7 cells. by Dora Posfai (4819011)

“…<p>(A) Relative mRNA expression of cells that were targeted by pooled AQP3 or SR-BI siRNAs at 50 nM. …”

Table_1_Cost-effectiveness analysis of colonoscopy and fecal immunochemical testing for colorectal cancer screening in China.DOCX by Yinan Ren (11080692)

“…The model simulated the health states of a cohort of 100,000 average-risk individuals aging from 50 to 75. …”

<i>Foxp1</i> deficiency augments the proportion of S-phase HFSC at anagen phase. by Jianzhi Zhao (414893)

“…<b>G-H:</b> Western blotting demonstrated a decrease of Foxp1 (G) and p19^ARF (H) protein levels within <i>cKO</i> hair follicles at anagen (P23). …”

Effectiveness of exercise on pain intensity and physical function in patients with knee and hip osteoarthritis: an umbrella and mapping review with meta-meta-analysis by Clovis Varongot-Reille (16971273)

“…</p> <p>41 meta-analyses were included, 43.9% of the studies had adequate methodological quality, and 56.1% of the studies had a low risk of bias. Moderate evidence was found that exercise decreases pain intensity (33 meta-analyses; SMD = −0.49; 95% CI −0.56 to −0.42), improves function (19 meta-analyses; SMD = −0.50; 95% CI −0.58 to −0.41), strength (6 meta-analyses; SMD = −0.57; 95% CI −0.70 to −0.44) and quality of life (SMD = −0.36; 95% CI −0.46 to −0.27) for patients with hip and knee osteoarthritis.…”

Data Sheet 1_Investigation of the anti-Huanglongbing effects using antimicrobial lipopeptide and phytohormone complex powder prepared from Bacillus amyloliquefaciens MG-2 fermentat... by Zhicheng Ding (18794422)

“…The results revealed that after 15 spray-drench treatments with L1 solution, the HLB infection rate decreased from 100 to 50%, the bacterial titer decreased by 51.9% compared with a 27.9% decrease in the control group. …”

Effect of APN on cell viability in control or PQ-incubated lung fibroblast. by Rong Yao (735448)

“…<p>PQ (0.3 mmol/L, 24 hours) decreased, whereas pretreated with APN (5 ug/mL, 2 hours) rescued, lung fibroblast viability at 24, 48 and 72 h after PQ incubation. …”

Responses of cells expressing various γ subunits to different concentrations of agonist. by Mariangela Chisari (257345)

“…No. of γ3 cells examined at 250 nM–20; at 1 µM–11; at 5 µM–17 and at 100 µM–17. No. of γ9 cells examined at 250 nM–23; at 1 µM–11; at 5 µM–17 and at 100 µM–14. …”

GBE enhanced oxygen consumption of isolated mitochondria and led to an up-regulation of mitochondrial DNA. by Virginie Rhein (243241)

“…(<b>A–D</b>) Values represent means ± S.E.</p>…”

Reinforcement learning models capture individual choice preference. by Jérôme Munuera (16819654)

“…This decrease was significantly different from optimistic subjects (<i>z</i> = -4.81, <i>p</i> < 0.001), who increased their choice preference (estimated trend = 3.76, 95% CI = [1.94, 5.57], p < 0.001). …”

qPCR analysis of rat EMCs and mouse heart explants treated with ICG-001. by Tomoyo Sasaki (87849)

“…<p>(A-E) ICG-001 significantly increased mRNA expression of <i>Gdf15</i> (2.5 µM and 5 µM at 24, 48 and 72 h), <i>Ctgf</i> (2.5 µM and 5 µM at 72 h), <i>Kit</i> (5 µM at 24 h), <i>Vegfa</i> (2.5 µM and 5 µM at 72 h) and <i>Sdf1</i> (2.5 µM at 48 h) in rat EMCs. …”

Glucose intolerance and acute insulin response (AIR) is improved with RU486 and C113176 treatment. by Jacqueline L. Beaudry (539019)

“…<p>Fasting (basal, 0 minutes) and stimulated blood glucose levels (mM) were measured at 5, 15, 30, 60, 90 and 120 minutes post oral glucose gavage (A). …”

The EEG power density changed under different drug treatments. by Chang-Rui Chen (467755)

“…The horizontal red lines at zero indicate significant changes. Values are means±SEM (n = 5–9). *<i>P</i><0.05, **<i>P</i><0.01, compared with vehicle control as assessed by one-way ANOVA, followed by PLSD testing.…”