Infection with <i>Shigella flexneri</i> M90T<i>ΔaroA</i> results in a decrease in TAMs number. by Katharina Galmbacher (252251)

Conditional ablation of <i>Ybx1</i> leads to a reduction in cortical progenitor cell pool and a decrease in cortical thickness. by Jian Zhang (1682)

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

ST2-104 decreases the Aβ_25-35-mediated increase in intracellular Ca²⁺. by Yingshi Ji (9013004)

Stress strain curves (from a1 to f1), stress—AE count plots (from a2 to f2) and stress—cumulative AE count plots (from a3 to f3) for the sample temperatures of 20°C, 50°C, 100°C, 1... by Nazlı Tunar Özcan (14833635)

Anthelmintics Derived from the Kinase Inhibitor SGI-1776 for the Treatment of Gastrointestinal Worm Infections by Mostafa A. Elfawal (22430138)

“…The unexpected SAR of compound <b>15</b> can be explained by computational modeling. We demonstrate the efficacy of optimized compound <b>50</b> as a new oral anthelmintic, which demonstrated better gut restriction properties and significantly reduced the fecundity of T. muris whipworm adults in infected mice. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

A decreased yield of RNP1, RNP2 and RNP5 formation in the presence of protein aGAR1 is counteracted by RNA-S by Bruno Charpentier (9519)

<i>MTHFR</i>677C → T genotype modulates the effect of a 5-year supplementation with B-vitamins on homocysteine concentration: The SU.FOL.OM3 randomized controlled trial by Leopold K. Fezeu (5309333)

“…</p><p>Methods</p><p>2381 patients with a personal history of cardiovascular disease were randomly assigned to one of four groups: 1) B-vitamins alone (560 μg of 5-methyl-THF, 3 mg of vitamin B₆ and 20 μg of vitamin B₁₂), 2) n-3 fatty acids alone (600 mg of EPA and DHA in a 2:1 ratio), 3) B-vitamins and n-3 fatty acids, and 4) placebo. …”

Whole sample storing experiment: Mean FECs of day 0, day 1 and day 2 for hookworm, <i>A</i>. <i>lumbricoides</i> and <i>T</i>. <i>trichiura</i>. by Felix Bosch (10024550)

Inhibition of ILK Decreases Bipolar and Multipolar Cytokinesis while Increasing Survival of Multinucleated Cells. by William K. A. Sikkema (574881)

Mean (± 1SD) growth rates (μ in day^-1) of the <i>Cylindrospermopsis raciborskii</i> strains during the incubation period (5 days) of the experimental cultures without (w... by Fabiana Araújo (5052323)

Structure and Properties of Single Crystalline CaMg₂Bi₂, EuMg₂Bi₂, and YbMg₂Bi₂ by Andrew F. May (2058100)

“…Despite charge-balanced empirical formulas, all three compounds are <i>p</i>-type conductors with Hall carrier concentrations of 2.0(3) × 10¹⁹ cm^–3 for CaMg₂Bi₂, 1.7(1) × 10¹⁹ cm^–3 for EuMg₂Bi₂, and 4.6(7) × 10¹⁹ cm^–3 for YbMg₂Bi₂, which are independent of temperature to 5 K. …”

Total BAL cell numbers and cell differential counts. by Ana Fernandez-Bustamante (766266)

Definitions of social influence metrics (i.e., betweenness centrality or age category) network level indices (weighted (W) diameter, global efficiency and modularity, as well as un... by Maggie Wiśniewska (11965538)

Measurements of HO-1 and dephosphorylated p38-MAPK concentrations in alveolar macrophages. by Ana Fernandez-Bustamante (766266)

Lung injury features. by Ana Fernandez-Bustamante (766266)