Weak Allele of <i>fzy-1</i>(<i>h1983</i>) Suppressed Neuron Decrease Phenotype of <i>bub-1</i>(<i>fw8</i>). by Xiangming Wang (372213)

Synthesis, Biological Evaluation, Structure–Activity Relationship, and Mechanism of Action Studies of Quinoline–Metronidazole Derivatives Against Experimental Visceral Leishmaniasi... by Akanksha Upadhyay (6732857)

“…In our efforts to identify novel chemical scaffolds for the development of antileishmanial agents, a series of quinoline–metronidazole hybrid compounds was synthesized and tested against the murine model of visceral leishmaniasis. …”

Skin histology in control and obesity groups. by Yoshiko Horie (4923043)

Change of the immune microenvironment in MC38 S.C. tumors of <i>S100a4-Cre; Ext1</i>^<i>f/f</i> mice. by Ayumi Niwa (6256790)

“…Data represent mean ± SEM (N = 6 for each cohort, unpaired t-test). Scale bar = 50 μm. (C) Microarray analysis of MC38 S.C. tumor of <i>S100a4-Cre; Ext1</i>^<i>f/f</i> and control mice (N = 4 for each cohort). …”

Distribution of pulmonary ventilation assessed by center of ventilation (CoV) presented over the five time points: Induction-SB, MV-5min, MV-30min, MV-late and recovery-SB. by Milena S. Nascimento (14803681)

<i>F</i>. <i>oxysporum</i> f. sp. <i>albedinis</i> genome code for a large repertoire of secreted proteins. by Maryam Rafiqi (12647200)

Locomotion and turning angle sizes of adult <i>D</i>. <i>melanogaster</i>, <i>D</i>. <i>simulans</i>, <i>D immigrans</i>, <i>D</i>. <i>subobscura</i> and <i>D pavani</i> in Petri d... by Jeannette Silva-López (16541854)

Flow chart for patients inclusion. by Haruka Imai (3703819)

“…Following this, antibiotic prescription was associated with a decreased 28-day mortality rate (2.3% vs. 3.6%) and in-hospital mortality rate (4.0% vs. 5.0%) compared with the control group. …”

The outcome measures in IPTW analysis. by Haruka Imai (3703819)

“…Following this, antibiotic prescription was associated with a decreased 28-day mortality rate (2.3% vs. 3.6%) and in-hospital mortality rate (4.0% vs. 5.0%) compared with the control group. …”

Contingency relation between IPI before and IPI after each pulse. by Laura N. Kloepper (8173881)

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Table_1_Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts.DOCX by Hong Zhang (25820)

“…However, EMPA did specifically decrease cardiac lactate labeling in the ¹³C glucose perfusions (¹³C labeling of lactate: 58 ± 2% vs. 50 ± 3%, for vehicle and EMPA, respectively; P = 0.02), without changes in other glucose metabolic pathways. …”

Anti TK1-sdAb-Fc antibodies elicit ADCC responses against NCI-H460 cells expressing mTK1. by Edwin J. Velazquez (8724405)

EIF5A2 or MTA1 expression levels influenced the aggressiveness of GC cells in vitro. by Qing-Bin Meng (707083)

Triclosan Dioxygenase: A Novel Two-component Rieske Nonheme Iron Ring-hydroxylating Dioxygenase Initiates Triclosan Degradation by Yiran Yin (19144130)

“…The highest amino acid identity of TcsA and the large subunits of other dioxygenases in the same family was only 35.50%, indicating that TcsAB is a novel dioxygenase. …”

Intrathecal KN93 injection attenuated fentanyl-induced hyperalgesia and decreased the level of <i>p</i>-CaMKIIα in spinal cord but not CeLC in OIH rats. by Zhen Li (1234644)

The second-order rate-yield tradeoff demonstrated by decreasing the P/O ratio and and knocking out <i>gnd</i> (“Δ<i>gnd</i>”) in ME-model simulations. by Chuankai Cheng (6791417)