Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization by Yin Yuan (597540)

“…Among them, compound 7c exhibited the best inhibitory activity with an IC₅₀ value of 41.8 nM. Furthermore, it was found that <b>7c</b> decreased the expression of stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo. …”

Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization by Yin Yuan (597540)

“…Among them, compound 7c exhibited the best inhibitory activity with an IC₅₀ value of 41.8 nM. Furthermore, it was found that <b>7c</b> decreased the expression of stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo. …”

Junction assembly in 3D cell cultures is severely impaired for W2A mutant. by Stefanie Bunse (491659)

“…Both R14E and V81D/V174D needed twice the Ca²⁺-concentration (0.8 mM) to show a significant increase in roundness emphasizing that in 3D, loss of either X-dimer or the <i>cis</i> interface leads to a decreased Ca²⁺-sensitivity in junction assembly (n for each condition ≥ 4, Mann-Whitney U test, p < 0.05). …”

Effect of Molecular Structure on the B3LYP-Computed HOMO–LUMO Gap: A Structure −Property Relationship Using Atomic Signatures by Ahmed Mohamed (628889)

“…The atomic fragments containing π-bonds in various aromatic compounds were found to be the most significant atomic Signatures, explaining nearly 50% of the variance in the data, with regression coefficients that decreased <i>E</i>_gap. …”

Fig 3 - by Jianfeng Yang (49036)

The Strong <i>In Vivo</i> Anti-Tumor Effect of the UIC2 Monoclonal Antibody Is the Combined Result of Pgp Inhibition and Antibody Dependent Cell-Mediated Cytotoxicity by Gábor Szalóki (631712)

“…At the same time, UIC2 alone did not affect the EC₅₀ value of DOX significantly. In xenotransplanted severe combined immunodeficient (SCID) mice co-treated with DOX, UIC2 and CsA, the average weight of Pgp⁺ tumors was only ∼10% of the untreated control and in 52% of these animals we could not detect tumors at all, while DOX treatment alone did not decrease the weight of Pgp⁺ tumors. …”

High levels of extracellular L-Cystine promoted the L-Cystine-L-Glutamate antiport via xCT and decreased the intracellular GSH/GSSG ratio in monocyte under the amino acid environme... by Eiji Kakazu (209203)

Table 1_Concurrent enhancement of provitamin A and yield in tropical maize hybrids.docx by Abebe Menkir (4511086)

“…Significant investments have thus focused on developing maize varieties that provide 50% of the daily vitamin A requirement for vulnerable populations. …”

Diagram illustrating thalamic network model and its cortical inputs. by Austin E. Soplata (4676017)

Canonical T7SS substrate EsxA is conserved across GBS T7SS subtypes I—III. by Brady L. Spencer (7294382)

Maximum network frequencies under TC cell propofol multiplier extremes. by Austin E. Soplata (4676017)

SPSS Data set persons with diabetes. by Joseph Ngmenesegre Suglo (9553147)

“…</p><p>Conclusion</p><p>A contextual family-oriented foot self-care education intervention is feasible, acceptable, and may improve knowledge and self-care with the potential to decrease diabetes-related complications. …”

Feasibility outcomes. by Joseph Ngmenesegre Suglo (9553147)

“…</p><p>Conclusion</p><p>A contextual family-oriented foot self-care education intervention is feasible, acceptable, and may improve knowledge and self-care with the potential to decrease diabetes-related complications. …”

Participant eligibility criteria. by Joseph Ngmenesegre Suglo (9553147)

“…</p><p>Conclusion</p><p>A contextual family-oriented foot self-care education intervention is feasible, acceptable, and may improve knowledge and self-care with the potential to decrease diabetes-related complications. …”

Predefined feasibility criteria. by Joseph Ngmenesegre Suglo (9553147)

“…</p><p>Conclusion</p><p>A contextual family-oriented foot self-care education intervention is feasible, acceptable, and may improve knowledge and self-care with the potential to decrease diabetes-related complications. …”

Demographic characteristics of participants. by Joseph Ngmenesegre Suglo (9553147)

“…</p><p>Conclusion</p><p>A contextual family-oriented foot self-care education intervention is feasible, acceptable, and may improve knowledge and self-care with the potential to decrease diabetes-related complications. …”

CONSORT flow diagram. by Joseph Ngmenesegre Suglo (9553147)

“…</p><p>Conclusion</p><p>A contextual family-oriented foot self-care education intervention is feasible, acceptable, and may improve knowledge and self-care with the potential to decrease diabetes-related complications. …”

Original and modified version of intervention. by Joseph Ngmenesegre Suglo (9553147)

“…</p><p>Conclusion</p><p>A contextual family-oriented foot self-care education intervention is feasible, acceptable, and may improve knowledge and self-care with the potential to decrease diabetes-related complications. …”

Image1_Adenosine A2A Receptor: A New Neuroprotective Target in Light-Induced Retinal Degeneration.TIF by Manuel Soliño (5410001)

Boxplot showing differences in vertebral cross-sectional growth between girls with increased (<i>n</i> = 14) and decreased vertebral body wedging (<i>n</i> = 13); <i>p</i> = 0.001. by Ervin Poorghasamians (3801475)