Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Elasticity values for variables for a simulated population of female fishers. by Roger A. Powell (21222116)

Image1_Phytochemical and toxicological evaluation of Zephyranthes citrina.JPEG by Muhammad Haseeb Ur Rehman (13848379)

“…Uric acid was raised at a dose of 100 mg/kg. In acute toxicity, at 2000 mg/kg, creatinine and uric acid increased while urea levels decreased. …”

Alpha rhythm cluster. by Eduardo Ekman Schenberg (801650)

“…B) Post-hoc analysis revealed decreases in the cluster depicted at left to be significant after 50 minutes from ingestion of ayahuasca (*p<0.05, corrected). …”

Pooling observations. by Stijn Bruneel (8113409)

Combined Serum Biomarkers in Non-Invasive Diagnosis of Non-Alcoholic Steatohepatitis by Mei Yang (51996)

“…</p><p>Results</p><p>Serum levels of CK-18-M30, FGF-21, IL-1Ra and PEDF increased, while OPG decreased in a stepwise fashion in controls, non-NASH NAFLD patients and NASH patients (<i>P</i> < 0.01). …”

Fig 6 - by Xiu-Qi Chen (13832389)

(A) Soil bin experiment site; (B) Air cannon cracking effect^‌‌. by Xia Li (14984)

Effects of riluzole on <i>I_NaP</i> and <i>I_NaT</i> in A-type neurons of the compressed DRG. by Rou-Gang Xie (179362)

“…<p>(A) Traces of <i>I_NaP</i> (bottom) induced by increasing applied voltage (top) in a compressed DRG neuron in the absence (control) and presence of riluzole (2, 10, 50 µM). …”

Fig 2 - by Mengnan Lu (12128694)

Code to generate Figure 3 from KDM1A paper by Jessica Chong (474458)

“…Additionally, as the specificity of the phenotype of interest increases, the proportion of individuals tested who have the phenotype (y-axis) naturally decreases, also resulting in increased power. A small decrease (60% to 50%) in the proportion of individuals who have the phenotype of interest can increase power more than sequencing 10,000 additional trios.…”

S1 Fig - by Charlotte Vajhøj (11864270)

EdU⁺/CC-1⁺ cells are present to at least 3 months post-TBI. by Krista A. Dent (709531)

Correlation between protein abundances and R_5-20 z-score among cases at baseline. Protein abundances, normalized to mean 0 and variance 1, are displayed on the y-axis. (... by Spela Kokelj (8356644)

Influence of the order of addition of fusing partners on HCVpp 1a fusion inhibition by Arb. by Elodie Teissier (232354)

“…a<p>Arb (11.3 µM) was pre-incubated sequentially with either HCVpp or R₁₈-labeled liposomes or both for the indicated times at 37°C before initiating lipid mixing by decreasing pH to 5.0 as described in the legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015874#pone-0015874-g002" target="_blank">Figure 2</a>. …”

Motor neurons in the cervical spinal cord of G93A mice at early and late stage of disease (cresyl violet staining). by Svitlana Garbuzova-Davis (81764)

“…In G93A mice, numerous motor neurons with vacuolization (asterisks) were found at (C) 13 weeks of age and (D) decreased numbers of motor neurons were noted in 17–18 week old mice. …”

Pre-incubation of SB105-A10 either with HIV-1_IIIb or HIV-1_ada strains inhibits the viral infectivity in dilution assay. by Isabella Bon (467395)

“…<p>HIV-1 strains were incubated for 1 hour at 37°C with SB105-A10 (20 µg/ml; 4.2 µM). Following this incubation the samples were diluted 50-fold to reduce dendrimer concentrations to a level below that at which SB105-A10 significantly inhibits HIV replication and challenged with activated PBMCs. …”

NB polarity and number are unaffected by knockdown of mitochondrial morphology proteins. by Dnyanesh Dubal (12085942)

S2 Fig - by Agnieszka D. Wardak (17941139)

Dehydrozingerone Improves Mood and Memory in Diabetic Mice via Modulating Core Neuroimmune Genes and Their Associated Proteins by Anuradha Kesharwani (21386000)

“…Additionally, anomalies in the glutamine-glutamate/GABA cycle could exacerbate diabetes-related cognitive deficits. Treatment with DH had a variety of advantages, including decreased neuroinflammation and neuronal cell death as well as the promotion of critical genes and proteins necessary to promote cognitive performance. …”