Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant by Ittipat Meewan (7455041)

“…Several drugs targeting the protease have been developed, but drug-resistant mutant strains emerged. Here, we screened a library and synthesized a novel class of small molecules based on a tryptophan derivative scaffold identified as HCV NS3/4A protease inhibitors that are active against both wild type and mutant form of the protease. …”

P28 GST enzymatic activity is essential to decrease inflammation in TNBS-induced colitis. by Aurore Sarazin (6162698)

Expression of P2X4 gene at day 5 of post infection with HCV. by Sobia Manzoor (11372369)

Umbelliprenin treatment decreased the expression of MMP2 and MMP9 in gastric cancer cells. by Lijing Zhang (463702)

<i>mbtK</i> deletion decreases phospholipid abundance during iron starvation. by Cressida A. Madigan (713924)

PF treatment decreases expressions of cytochrome c and Bax, but increases the expressions of Bcl-2. by Ruo-Bing Guo (298949)

DHT stimulation decreases apoptosis and induces cell proliferation in MDA-MB-453 cells. by Jatin Mehta (703766)

Comparison of AC and GC activity of mutants with the wild type at pH 7.5 and 9.0. Mean ± SEM are shown from experiments performed twice with quadruplicates. by Wajeed Syed (652639)

“…<p>– <i>sign in the last two columns indicates percentage decrease in GC activity relative to the wild type.</i></p><p>Comparison of AC and GC activity of mutants with the wild type at pH 7.5 and 9.0. …”

Oral administration of TVSE decreases angiogenesis in 4T1 tumors in BALB/c mice. by Hyun Sook Lee (8039876)

MALT1 inhibition in mDCs decreases cytokine production in zymosan-treated cells. by Celine Dumont (9327751)

Etomoxir and orlistat inhibit cell cycle progression and decreased proliferation rate in myeloma cells. by José Manuel Tirado-Vélez (304970)

Over-expression of IL13Rα2 is associated with decreased patient survival. by Christine E. Brown (167785)

Decreases in gene expression following ATF3 knock-down in EMT6 cells. by Leqin Yan (231387)

Serotonin deficiency decreases calcium transporters expression in the mammary gland on d 10 of lactation. by Jimena Laporta (383836)

Reduction of OPL and decreased number of horizontal cells in P18 Oc-deficient mice. by Michaela Kreplova (9239560)

<b>Glucagon Clearance is Decreased in Chronic Kidney Disease, but Preserved in Liver Cirrhosis</b> by Magnus F. G. Grøndahl (19160825)

Casein kinase 1.2 depletion decreases ZC3H11 phosphorylation. by Igor Minia (399074)

“…Procyclic cells expressing in situ tagged V5-CK1.2, with a tetracycline-inducible stem-loop RNAi construct, were induced with tetracycline (200g/ml). …”

Oral administration of BV decreased infiltrated inflammatory cells in BALF of asthmatic mice models. by Ran Fu (434520)

“…Each sample was tested for 3 times and averaged, all values were expressed as mean ± SD. * <i>P</i><0.05.</p>…”

Fluoxetine decreases the levels of abundant neuropeptides (NPY and CART) in hypothalamic differentiated neuroprogenitor cells. by Lígia Sousa-Ferreira (221509)

“…Mean ± SEM; n = 5; One-Way ANOVA; ns, p>0.05; *, p<0.05; **, p<0.01; ***, p<0.001 compared to control; NS, p>0.05, ^#, p<0.05, ^###, p<0.001 compared to fluoxetine.…”

Marimastat treatment resulted in decreased adiposity and liver weights and normalized macroscopic appearance of the liver. by Vincent E. de Meijer (343377)