Hyperacetylation of PS1 and BACE1 was suppressed by p300 specific inhibitor curcumin in N2a/APPswe cells. by Xi Lu (288663)

“…<p>(A) the p300 protein was markedly decreased in N2a/APPswe cells after being treated with curcumin; (B) curcumin dramatically reduced the enhancement effect of p300 in N2a/APPswe cells by immunocytochemistry, Magnification 400-fold, Scale bar: 50 µm; (C) curcumin treatment significantly suppressed the HATs activity in N2a/APPswe cells; (D) the Ac-H3 to PS1 and BACE1 promoter regions was much lower in N2a/APPswe cells after being treated with curcumin compared to DMSO (placebo) group; (E) the cellular Ac-H3 in N2a/APPswe cells was statistically significantly decreased after curcumin treatment; (F) N2a/APPswe cells after being treated with curcumin showed reduced binding of p300 to PS1 and BACE1 in N2a/APPswe cells. …”

<i>par2b</i> is partially required downstream of <i>ap1b1a</i> for aggregate formation and increased <i>mmp9</i> expression in the epidermis. by Julia Hatzold (44687)

“…Of the <i>atp1b1a-/-; par2b-/-</i> double mutants, 50% did not show obvious <i>mmp9</i> staining, comparable to wild type controls (compare with <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010873#pgen.1010873.g002" target="_blank">Fig 2M</a>), and the other 50% showed weak <i>mmp9</i> staining intensity comparable to that shown in panel (G). …”

Fig 11 - by Sana Khalid (132742)

ICA decomposition quality is sensitive to recording spatial and temporal resolution. by Sydney C. Weiser (15383531)

“…Examples of neuronal (n; blue), artifact (vascular—v; red/other -o; orange), and noise (gray) ICs are indicated in the variance plot are shown below. …”

DataSheet1_Adverse event profiles of adjuvant treatment with opicapone in Parkinson’s disease: A systematic review and meta-analysis.PDF by Luwen Xie (14167338)

“…Any TEAEs, SAEs and treatment discontinuation all occurred at rates of 62.9%, 4.8% and 9.3%, respectively. TEAEs with opicapone 50 mg that were reported by more than 5% of patients in long-term studies included dyskinesia (16.1%), dry mouth (12.1%), medication effect decreased (12.1%), PD exacerbated (7.8%), blood creatine phosphokinase level raised (7.4%), nausea (6.1%) and insomnia (5.1%). …”

The impact of sublethal effects of fungal infection on mosquito feeding biology. by Penelope A. Hancock (223305)

“…<p>Equilibrium daily EIR as a function of the mean time to death from fungal infection () for three values of the daily probability of fungal infection (): A, <i>C</i> = 0.1 B, <i>C</i> = 0.5 C, <i>C</i> = 0.9. …”

Image1_A simulation study on the climatic responses to short-lived climate pollutants changes from the pre-industrial era to the present.TIF by B. Xie (42914)

“…By looking at other variable responses, we found that precipitation had been increased by about 0.10 mm d⁻¹ in mid- and high-latitudes and decreased by about 0.20 mm d⁻¹ in subtropical regions, with the global annual mean value of 0.02 mm d⁻¹. …”

Data_Sheet_1_A Connectome-Based, Corticothalamic Model of State- and Stimulation-Dependent Modulation of Rhythmic Neural Activity and Connectivity.pdf by John D. Griffiths (9873641)

DataSheet_1_A first-in-human, open-label, dose-escalation and dose-expansion phase I study to evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics, and antitumor ac... by Zhiyu Huang (638377)

“…Adverse events (AEs) were graded per National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0, and antitumor activity of QL1604 was evaluated by investigators on the basis of Response Evaluation Criteria in Solid Tumors version 1.1.…”

Data_Sheet_2_Effect of Levothyroxine on Blood Pressure in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis.doc by Weiwei He (32469)

“…Meta-analysis of the 19 prospective follow-up studies found that LT4 therapy significantly decreased SBP and DBP by 4.80 mmHg (95%CI −6.50 to −3.09, P < 0.001) and 2.74 mmHg (95%CI −4.06 to −1.43, P < 0.001), respectively.…”

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs by Sarah A. Stewart (9198984)

“…Implants could be specifically developed in order to match the specific release rate required for a number of drugs for a wide range of conditions.…”

Behavioural and Brain Gene Expression Profiling in Pigs during Tail Biting Outbreaks – Evidence of a Tail Biting Resistant Phenotype by Emma Brunberg (423126)

“…<div><p>Abnormal tail biting behaviour is a major welfare problem for pigs receiving the behaviour, as well as an indication of decreased welfare in the pigs performing it. …”

Data_Sheet_1_Effect of Levothyroxine on Blood Pressure in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis.docx by Weiwei He (32469)

“…Meta-analysis of the 19 prospective follow-up studies found that LT4 therapy significantly decreased SBP and DBP by 4.80 mmHg (95%CI −6.50 to −3.09, P < 0.001) and 2.74 mmHg (95%CI −4.06 to −1.43, P < 0.001), respectively.…”

Time’s Up. Descriptive Epidemiology of Multi-Morbidity and Time Spent on Health Related Activity by Older Australians: A Time Use Survey by Tanisha Jowsey (396920)

“…A recall questionnaire was developed, piloted, and adjusted. …”

DataSheet1_Response of soil carbon dioxide efflux to temporal repackaging of rainfall into fewer, larger events in a semiarid grassland.pdf by Matthew C. Roby (13835971)

“…We found that repackaging rainfall into few/large events with long dry intervals decreased seasonal cumulative F_s. …”

Data_Sheet_1_Targeting Aspergillus fumigatus Crf Transglycosylases With Neutralizing Antibody Is Relevant but Not Sufficient to Erase Fungal Burden in a Neutropenic Rat Model.PDF by David Chauvin (6504965)

“…In addition, we highlighted the role of Crf proteins in fungal growth, using a deletion mutant for CRF1 gene, for which a growth decrease of 23.6% was observed after 48 h. …”

Fig 12 - by Sana Khalid (132742)

Sacrifice Template Strategy to the Fabrication of a Self-Cleaning Nanofibrous Membrane for Efficient Crude Oil-in-Water Emulsion Separation with High Flux by Mingming Wu (268965)

“…However, most materials are extremely susceptible to pollution during oil–water separation, which drastically restricts their widespread applications. Herein, a momordica-charantia-like nanofibrous membrane (MCNM) with underwater superoleophobic performance was fabricated through a sacrifice template strategy by the electrospinning solution of zeolitic imidazolate framework-8 (ZIF-8) and polyacrylonitrile particles. …”

Table_1_A meta-analysis to examine whether nitrification inhibitors work through selectively inhibiting ammonia-oxidizing bacteria.docx by Jilin Lei (13115496)

“…The abundance of AOB amoA genes was dramatically reduced by about 50% with NI application in most soil types. …”

Table_1_A meta-analysis to examine whether nitrification inhibitors work through selectively inhibiting ammonia-oxidizing bacteria.xlsx by Jilin Lei (13115496)

“…The abundance of AOB amoA genes was dramatically reduced by about 50% with NI application in most soil types. …”