Image_5_Modification of Barley Plant Productivity Through Regulation of Cytokinin Content by Reverse-Genetics Approaches.pdf by Katarína Holubová (6012125)

“…Increasing grain yield by mean of manipulation of endogenous cytokinin content was assayed by the silencing of the HvCKX1 gene. …”

Table_5_Modification of Barley Plant Productivity Through Regulation of Cytokinin Content by Reverse-Genetics Approaches.pdf by Katarína Holubová (6012125)

“…Increasing grain yield by mean of manipulation of endogenous cytokinin content was assayed by the silencing of the HvCKX1 gene. …”

Image_5_Modification of Barley Plant Productivity Through Regulation of Cytokinin Content by Reverse-Genetics Approaches.pdf by Katarína Holubová (6012125)

“…Increasing grain yield by mean of manipulation of endogenous cytokinin content was assayed by the silencing of the HvCKX1 gene. …”

Table_5_Modification of Barley Plant Productivity Through Regulation of Cytokinin Content by Reverse-Genetics Approaches.pdf by Katarína Holubová (6012125)

“…Increasing grain yield by mean of manipulation of endogenous cytokinin content was assayed by the silencing of the HvCKX1 gene. …”

Downregulation of CD36 impaired phagocytic capacity and is associated with a proinflammatory phenotype of <i>Mst1</i> deficiency macrophages. by Jianyang Li (461703)

Adult schistosome motility and egg production are differentially affected by the nine N-acyl homoserine lactones. by Helen Whiteland (6743339)

Inactive <i>Hnf1α</i> targets in <i>Hnf1a^−/−</i> cells exhibit local enrichment of H3-Lys27me3, decreased H3-Lys4me2, and reduced DNAse I sensitivity. by Reini F. Luco (91817)

The Design, Synthesis, and Characterizations of Spore Germination Inhibitors Effective against an Epidemic Strain of Clostridium difficile by Shiv K. Sharma (1945762)

“…To circumvent this problem, a series of cholic acid amides were synthesized and tested against R20291. …”

Image_5_Neural Tube Defects and ZIC4 Hypomethylation in Relation to Polycyclic Aromatic Hydrocarbon Exposure.TIF by Yun Huang (169805)

“…Among all identified genes, ZIC4 had the largest number of differently methylated CpG sites (n = 13) in the promoter region and 5′ UTR. Significantly decreased methylation in the ZIC4 promoter region and 5′ UTR was verified in an independent cohort of 80 cases and 32 controls (p < 0.001) utilizing the Sequenom EpiTYPER platform. …”

The Paf1 complex promotes displacement of histones upon rapid induction of transcription by RNA polymerase II-5 by Heather A Marton (88501)

Krt5-β-catenin-LOF results in reduced basal keratinocytes and proliferation, and leads to a smaller CVP. by Dany Gaillard (345499)

“…<p><b>(A)</b> Many proliferating Ki67⁺ cells (magenta) are evident at the basement membrane of a control CVP, while in Krt5-β-catenin LOF mutants at 4 days and 2 weeks, fewer Ki67⁺ cells are evident in each CVP trench. …”

A model with two target-cell populations and viral competition in one of these populations matches <i>in vivo</i> data and predicts that R5 inhibitors accelerate AIDS onset. by Ariel D. Weinberger (169848)

“…Increased CCR5 inhibitor efficacy accelerates X4 emergence and increases X4's viral set point.…”

The growth of co-transformed cells in the peritoneal cavity alters their cellular gene expression to mirror that of PEL biopsies. by Mitchell Hayes (5334887)

Table5_Meta-analysis and trial sequential analysis of shexiang baoxin pill for coronary slow flow.DOCX by Hongxin Guo (13277364)

“…Meta-analysis showed that compared with CWM treatment alone, SXBXP combined with CWM further improved the angina pectoris efficacy [RR = 1.37, 95% CI (1.23, 1.52), p < 0.000 01] and nitric oxide (NO) level [WMD = 11.32, 95% CI (0.04, 22.59), p = 0.049], decreased the mean corrected TIMI frame count (CTFC) [WMD = −4.23, 95% CI (−5.51, −2.95), p < 0.000 01], CTFC of the left anterior descending artery (LAD) [WMD = −6.36, 95% CI (−12.07, −0.65), p = 0.029], left circumflex artery (LCX) [WMD = -5.73, 95% CI (−8.79, −2.67), p < 0.000 01], and right coronary artery (RCA) [WMD = −6.72, 95% CI (−10.60, −2.84), p = 0.001], decreased the positive rate of treadmill exercise test [RR = 0.45, 95% CI (0.25, 0.83), p = 0.010], endothelin-1 (ET-1) level [WMD = -11.03, 95% CI (−13.92, −8.14), p < 0.000 01], high-sensitivity C-reactive protein (hs-CRP) [WMD = −1.95, 95% CI (−2.57, −1.34), p < 0.000 01], and adverse reactions [RR = 0.20, 95% CI (0.05, 0.85), p = 0.030]. …”

<i>In vivo</i> HDL protects the heart from IR injury via STAT3 activation. by Sarah Pedretti (703288)

Trichostatin A, an epigenetic modifier, mitigates radiation-induced androphysiological anomalies and metabolite changes in mice as evident from NMR-based metabolomics by Teena Haritwal (5847362)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”