Image_6_ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization.JPEG by Samuel Peña-Díaz (8131068)

“…ZPD-2 inhibits the aggregation of wild-type α-Syn and the A30P and H50Q familial variants in vitro at substoichiometric compound:protein ratios. …”

Image_1_ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization.JPEG by Samuel Peña-Díaz (8131068)

“…ZPD-2 inhibits the aggregation of wild-type α-Syn and the A30P and H50Q familial variants in vitro at substoichiometric compound:protein ratios. …”

Image_5_ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization.JPEG by Samuel Peña-Díaz (8131068)

“…ZPD-2 inhibits the aggregation of wild-type α-Syn and the A30P and H50Q familial variants in vitro at substoichiometric compound:protein ratios. …”

Stress responses after knockdown of octopamine receptor OAMB and serotonin receptor 5-HT_1A in IPCs. by Jiangnan Luo (218899)

“…In an earlier study it was shown that 5-HT_1A knockdown decreased starvation resistance <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0099732#pone.0099732-Luo1" target="_blank">[22]</a>. …”

Erratum: Aspirin plus Clopidogrel as Secondary Prevention after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis by Zhang Q. (2863868)

“…Stratified analysis of long-term treatment revealed that the combination treatment did not decrease the risk of stroke recurrence (RR, 0.92; 95% CI 0.83-1.03, p = 0.15), but was associated with a significantly higher risk of hemorrhagic stroke (RR, 1.67; 95% CI 1.10-2.56, p = 0.02) and major bleeding events (RR, 1.90; 95% CI 1.46-2.48, p < 0.01). …”

Impact of Renal Dysfunction on Mid-Term Outcome after Transcatheter Aortic Valve Implantation: A Systematic Review and Meta-Analysis by Chi Chen (67021)

“…A per unit decrease in serum creatinine was also associated with a higher mortality at mid-term follow-up (univariate HR: 1.24, 95% CI: 1.18–1.30; multivariate HR: 1.19, 95% CI: 1.08–1.30).…”

iNKT Cells Are Responsible for the Apoptotic Reduction of Basophils That Mediate Th2 Immune Responses Elicited by Papain in Mice Following γPGA Stimulation by Hyun Jung Park (116737)

“…The depletion of basophils by a single injection of γPGA was dependent on the TLR4/DC/IL12 axis. CD1d-dependent Vα14 TCR invariant natural killer T (iNKT) cells are known to regulate a variety of immune responses, such as allergy. …”

Table_1_The hemodynamic stability of remimazolam compared with propofol in patients undergoing endoscopic submucosal dissection: A randomized trial.docx by Yuwei Qiu (7455965)

“…</p>Results<p>The incidence of hypotension decreased by 50%, from 67.9% in propofol group to 32.1% in remimazolam group (p < 0.01). …”

Data Sheet 1_Preliminary evaluation of a novel serotype O foot-and-mouth disease mRNA vaccine.docx by Jingang Zhao (20416198)

“…Consequently, there exists an urgent need for safer and more effective innovative vaccines in animal husbandry. In this study, we aimed to develop a lipid nanoparticle mRNA vaccine based on VP1-3A-3D epitopes from serotype O FMD and to verify its specific expression within cytoplasmic and injection sites. …”

A Genetically Hard-Wired Metabolic Transcriptome in <em>Plasmodium falciparum</em> Fails to Mount Protective Responses to Lethal Antifolates by Karthikeyan Ganesan (269200)

“…No genes were reproducibly up-regulated by more than 2-fold until 24 h after initial drug exposure, even though clonal viability decreased by 50% within 6 h. We predicted and showed that while the parasites do not mount protective transcriptional responses to antifolates in real time, <em>P. falciparum</em> cells transfected with human DHFR gene, and adapted to long-term WR99210 exposure, adjusted the hard-wired transcriptome itself to thrive in the presence of the drug. …”

Data_Sheet_1_Efficacy and Safety of Remimazolam for Procedural Sedation: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis.docx by Bo-Jyun Jhuang (11187882)

“…Compared with the use of midazolam, the utilization of remimazolam resulted in an increase in procedure success rate [odds ratio (OR) = 9.01, 95% confidence interval (CI): 2.35–34.57], a reduction in the application of rescue medication (OR = 13.58, 95% CI: 3.46–53.28), a decrease in time to recovery [minutes, weighted mean difference (WMD) = −5.70, 95% CI: −8.68 to −2.72], and a better cognitive recovery of Hopkins Verbal Learning Test-Revised (WMD = 5.22, 95% CI: 2.88–7.55). …”

Dose- and time-dependent effect of IL-13, IL-4, and TGF-β1 on benzamil-sensitive <i>I</i>_sc and TEER in HBECs. by Anusree Sasidharan (19226521)

Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration by Jeanette M. Metzger (8259900)

“…<div><p>Cardiac dysautonomia is a common nonmotor symptom of Parkinson’s disease (PD) associated with loss of sympathetic innervation to the heart and decreased plasma catecholamines. …”

Galunisertib (LY2157299), a transforming growth factor-β receptor I kinase inhibitor, attenuates acute pancreatitis in rats by X. Liu (589632)

“…<div><p>Galunisertib (LY2157299), a selective ATP-mimetic inhibitor of TGF-β receptor I (TGF-βRI), is the only known TGF-β pathway inhibitor. …”

Time course of IRF1 and IFITM3 RNA and protein expression across conditions. by Tyron Chang (9922533)

Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice by Sayantani Sinha (716150)

“…Surprisingly, it is not known whether such tumors also form in endochondral elements of the craniofacial skeleton. Here, we carried out a retrospective analysis of cervical spine MRI and CT scans from 50 consecutive HME patients that included cranial skeletal images. …”

Supplementary Material for: The risk of cardiovascular disease following aromatase inhibitor therapy for breast cancer in postmenopausal women: a systematic review and meta-analysi... by figshare admin karger (2628495)

“…However, there was a significant decrease in the risk of myocardial infarction (RR 0.77, 95% CI: 0.65-0.90, p<0.05) in the AI group when compared to no hormonal treatment. …”

Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies by Hadith Tangestani (6202022)

“…VDFs may increase serum 25(OH)D and BMD while decrease serum PTH levels. We did not find any beneficial effect of VDFs on BTM.…”

Table 1_Efficacy of submucosal administration of tramadol on acute pain following third molar surgery: a systematic review and meta-analysis.docx by Ahmad Salem Assari (20277900)

“…In addition, tramadol demonstrated a significant decrease in post-operative pain.</p>Conclusion<p>Submucosal tramadol is an efficient, safe, and dependable method for reducing post-operative acute pain, particularly in the first 6 h following impacted third molar surgery. …”

Identification and characterization of methicillin-resistant Staphylococcus spp. isolated from surfaces near patients in an intensive care unit of a hospital in southeastern Brazil by Luciano Freitas Fernandes (10372545)

“…The presence of the mecA gene was investigated using PCR. RESULTS: We observed that 44 out of the 50 sampling sites presented grown isolates in the methicillin-resistant Staphylococcus aureus medium. …”