Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Relationships between each parameter relative change and stent wire mesh density. by Shunsuke Masuda (12859231)

PIK3C3 promotes <i>Listeria monocytogenes</i> cell-to-cell spread in Caco-2 cells. by Steven J. Rolland (21376879)

PIK3C3 promotes <i>Shigella flexneri</i> cell-to-cell spread in Caco-2 cells. by Steven J. Rolland (21376879)

PRISMA flow diagram. by Apoorva Anand (17921197)

“…Lower sensitivity was attributed to absence of symptoms, errors in test conduct and absence of supervision or a digital support. We found no difference in COVIDST sensitivity between delta and omicron pre-dominant period. …”

Aβ-induced BACE1 mRNA and protein expressions in activated N2a Swe cells and their reductions by taxifolin and cilostazol. by So Youn Park (141327)

“…Significant decreases in BACE1 protein expression by taxifolin (50 or 100 μM), cilostazol (30 μM), and by 30 μM quercetin (a flavonoid) after 24 hr of treatment. …”

Table1_Effectiveness of dapagliflozin as an insulin adjunct in type 1 diabetes: a semi-mechanistic exposure-response model.DOC by Victor Sokolov (14181554)

“…Even so, this association remained flat, with a 50% decrease in the basal insulin dose from pretreatment level, resulting in ∼5% increase in glucose exposure. …”

The effects of intrathecal AMD3100 on pain pathways in the ipsilateral L3-L5 spinal cord segment of pSNL-injured mice. by Xin Luo (428648)

Expression of the miR-34 family, Axl and HNF4A in RCC. by Helena K. Fritz (785130)

“…<p>The levels of miR-34a, Axl mRNA, and HNF4A mRNA were determined using RT-qPCR in a cohort of RCC patients (cohort N = 198, ccRCC N = 152, normal N = 50). …”

Table_5_Genetic Stock Identification and Adaptability of Hatchery-Reared Black Rockfish, Sebastes schlegelii, Released Into the North Yellow Sea waters.XLSX by Qi Liu (33068)

Altered ERK 1/2 and Smad 1/5/8 phosphorylation observed in primary rat hippocampal cells upon iAβ expression. by Eric Cruz (340766)

“…<b>(B)</b> Plot of relative densitometry analysis of phospho-ERK 1/2 with data corresponding to biological replicates shown as mean ± SE (n = 3). Statistically significant (p < 0.05) decrease in phospho-ERK 1/2 observed in iAβ transduced cells restored upon pre-treatment with PLX4032. …”

An Allosteric Modulator of RNA Binding Targeting the N‑Terminal Domain of TDP-43 Yields Neuroprotective Properties by Niloufar Mollasalehi (9511076)

“…<i>In silico</i> docking of 50K compounds to the NTD domain of TDP-43 identified a small molecule (nTRD22) that is bound to the N-terminal domain. …”

HRs, 95% CIs, and <i>p</i>-values for the association of duration of lithium exposure with the development of dementia (and its subtypes) by Cox proportional hazards models. by Shanquan Chen (3417512)

Meta-analyses of COVIDST diagnostic accuracy. by Apoorva Anand (17921197)

“…Lower sensitivity was attributed to absence of symptoms, errors in test conduct and absence of supervision or a digital support. We found no difference in COVIDST sensitivity between delta and omicron pre-dominant period. …”

Liver expression of LDLR and ABCA1 protein in mice with hepatic MTP knockdown. by Stephanie M. Marshall (223125)

A pro-inflammatory and pro-fibrogenic cytokine profile developed in infected iNOS-KO rats. by Jia Shen (1828945)

Hepatic and intestinal MTP expression following MTP ASO treatment. by Stephanie M. Marshall (223125)

Upon Photoactivation in <i>m</i>Nrp1-Cherry-Positive Vesicles, α5-PA-GFP Recycles Back to Membrane Adhesions by Donatella Valdembri (268183)

“…The time-lapse plot (lower panel) shows that the α5-PA-GFP fluorescence intensity decreases in the vesicles, while it increases at the plasma membrane. …”