<i>Mab21l2</i> is required for the formation of the septum transversum mesenchyme near hepatoblasts and for normal liver development. by Yohei Saito (180130)

“…Scale bar represents 30 µm (A–H, Q–T), 50 µm (I, J, M–P) and 100 µm (K, L).…”

Table_1_Thalidomide Combined With Azathioprine as Induction and Maintenance Therapy for Azathioprine-Refractory Crohn's Disease Patients.DOCX by Tong Li (206968)

“…Both Crohn's Disease Endoscopic Index of Severity (13.4 ± 4.92 vs. 6.12 ± 5.24, P < 0.001) and Rutgeerts scores (3.23 ± 0.73 vs. 1.77 ± 1.59, P = 0.003) were significantly decreased with the use of combination therapy. Adverse events occurred in 62 (50.8%) patients, but only 13 (10.7%) necessitated therapy discontinuation. …”

SPI under <i>K</i> different distance ranges. by Thao Vu (3363083)

“…<p><i>K</i> values were incremented from 25 to 100 in steps of 5. At each <i>K</i>, a sequence of distance breaks was generated by linearly decreasing from <i>d</i>_<i>K</i> to 0 on a log scale. …”

Increasing network size does not guarantee convergence to a balanced state. by Pierre Ekelmans (15470955)

“…The inset shows the excitatory rate for network sizes from <i>N</i> = 4 × 10³ (blue) to <i>N</i> = 5 × 10⁵ (red), in steps of ×10^0.1 obtained using the SSN. …”

Figure 7 from KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma by Elisabet Figuerola-Bou (22618659)

“…<p>KDM6B KO decreases tumor growth. <b>A,</b> Colony formation assay of KDM6B KO cells (sgRNA#1 and sgRNA#2) compared with parental and sgCTRL A-673 cells. …”

Right Main Bronchus Transection After Blunt Thoracic Trauma by Ivan CH Siu (11978159)

“…<p>Tracheobronchial injury is a rare occurrence in people with blunt thoracic trauma, and it is associated with significant mortality (1). …”

First year physical activity findings from turn up the HEAT (Healthy Eating and Activity Time) in summer day camps by R. Glenn Weaver (3873328)

“…Boys in comparison SDCs increased by +1.6% (81–83%) and girls decreased by -5.5% (76–71%). Process data indicated intervention SDCs successfully extended and enhanced PA opportunities, but were unable to expand PA opportunities, compared to control SDCs.…”

Stit is required for optimal growth of the wing epithelium. by Fergal O'Farrell (435865)

“…The number of discs examined (<i>n</i>) is indicated. Scale bar, 50 µm. (H) 10 min of EdU incorporation did not show a compartment-specific change in cells entering into S-phase in <i>ap</i>><i>Stit^KD</i> discs versus <i>ap>GFP</i> control discs. …”

Notch activation drives apical constriction and epithelial fold. by Hui-Yu Ku (3185502)

“…(D) Proportions of the three cell populations in <i>hth</i>><i>N</i>^<i>DN</i> EAD. There is a reduction of cells with a decreasing apical area (red), and an increase of cells with a fluctuating apical area (blue). …”

Computational optimization of the circuits for specific functions further reveals general design principles. by Xiaojing Yang (154840)

“…(C) <i>In silico</i> evolution to optimize the catalytic efficiencies of the kinases for a desired function in discrete steps of mutation and selection (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001673#pbio.1001673.s005" target="_blank">Figure S5A</a> for a detailed illustration). …”

Muscular and metabolic responses to different Nordic walking techniques, when style matters by Barbara Pellegrini (801238)

“…Ten NW instructors volunteered to walk on a treadmill at 5.5 km•h^-1 in five conditions: walking (W), Nordic walking (NW), NW with a weak poling action (NW_weak), with straight-upper limbs moving the shoulders (NW_shoulder) and with elbow flexion-extension pattern and shoulder freezed (NW_elbow). …”

datasheet1_The Expiry of Humira® Market Exclusivity and the Entry of Adalimumab Biosimilars in Europe: An Overview of Pricing and National Policy Measures.pdf by Evelien Moorkens (4723848)

“…When reported, discounts/rebates on originator adalimumab after loss of exclusivity ranged from 0% to approximately 26% (Romania), 60% (Poland), 80% (Denmark, Italy, Norway), and 80–90% (Netherlands), leading to actual prices per pen or syringe between €412 (Finland) and €50 – €99 (Netherlands). To leverage competition following entry of biosimilar adalimumab, only a few countries adopted measures specifically for adalimumab in addition to general policies regarding biosimilars. …”

Image_8_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_2_Combined Effect of CYP2C19 Genetic Polymorphisms and C-Reactive Protein on Voriconazole Exposure and Dosing in Immunocompromised Children.JPEG by Juan Chen (61123)

“…Covariates associated with voriconazole plasma concentrations and dose requirements were adjusted by using generalized linear mixed-effect models.</p>Results<p>A total of 682 voriconazole steady-state trough concentrations from 91 Chinese pediatric patients were included. …”

Image_5_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

4-Octyl itaconate attenuates renal tubular injury in db/db mice by activating Nrf2 and promoting PGC-1α-mediated mitochondrial biogenesis by Muqing Shao (15238576)

“…<i>Irg1</i> knockout mice were generated. db/db mice were treated with 4-octyl itaconate (4-OI, 50 mg/kg), a derivative of itaconate, for 4 weeks. …”

Simulated dependence of [Ca²⁺] on electrical coupling following modulation of other K_ATP parameters. by Aleena M. Notary (625801)

“…<b>B).</b> As in A, for <i>g</i>_<i>coup</i> = 0pS. <b>C).…”

Image_1_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_6_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Defective optineurin causes autophagy failure. by Masaya Fukushi (216872)

“…(E) Autophagy flux after infection is shown as a decreased GFP/RFP ratio in parental (<i>n</i> = 4) and two <i>Optn</i>-KO clones (<i>n</i> = 4 each) of GFP-LC3-RFP-LC3ΔG MEFs infected with SeV (Cantell strain). …”