Scribble cKO oligodendrocytes produce shorter myelin internodes. by Andrew A. Jarjour (343100)

“…<p>Myelin internodal lengths were determined in teased fibre preparations from P16 Scribble WT (A) and cKO (B) mice by measuring the distance between adjacent Caspr-positive paranodes (green). …”

Extracellular lactate and glucose levels in the hippocampus, measured before, during, and after behavioral testing. by Lori A. Newman (337628)

“…Lactate concentrations significantly increased at the beginning of behavioral testing (n = 4; t₃ = 4.77, p<0.02; MEAN ± SEM: 112.50%±3.15%). In contrast, glucose concentrations decreased after 5 minutes on the task (n = 3; t₂ = 3.58, p<0.05; MEAN ± SEM: 86.19%±7.73%). …”

Data Sheet 1_Brain microvascular endothelial cells differentiated from a Friedreich’s Ataxia patient iPSC are deficient in tight junction protein expression and paracellularly perm... by Frances M. Smith (17770776)

“…These data indicate that decreased barrier integrity is a pathophysiological phenotype of FA brain microvascular endothelial cells. …”

A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation... by Thirumal Kumar, D

“…Our predictions revealed that E17K, R67W, V164G, E319G, R391G, D32Y, L52H, L52R, and W80R were the most pathogenic mutations. …”
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Top Genes with Significantly Increased Transcript Levels Systemically During SSTI¹. by Rebecca A. Brady (408084)

“…</p><p>²Function determined via Entrez (<a href="http://www.ncbi.nlm.nih.gov/" target="_blank">www.ncbi.nlm.nih.gov</a>) or Uniprot (<a href="http://www.uniprot.org/" target="_blank">www.uniprot.org</a>)</p><p>³LFC = Log Fold Change</p><p>Italicized values indicate transcripts are significantly decreased at the indicated time point.…”

Analysis of total and phosphorylated RPS6 protein in WT liver and regenerating ΔS6 liver reveals differential mTOR activity in hepatocytes and biliary cells and that RPS6-expressin... by Sarah A. Comerford (3854917)

“…Original magnifications: a, b, e, and f (x 112); c and d (x 225). Scales bars, 50μ. …”

ATF2 is required for miR-30b regulation of TGFβ2 expression. by Grant A. Howe (2558611)

“…<p>(A) JDP2 mRNA expression was assessed in HUVECs transfected with miR-30b mimic (20 nM) as compared to control by qRT-PCR. …”

Direct recruitment of polarity factors to the patch enables highly mobile clusters. by Samuel A. Ramirez (4951921)

“…<b>(E)</b> Patch diffusivities as a function of total GEF for simulations where <i>k</i>_<i>6</i> has been increased to either 1 μm²/s or 50 μm²/s. …”

Table 1_Does screening mode matter? A repeated cross-sectional study of computer self-administered vs. clinician-administered screening of youth substance use in pediatric primary... by Chloe Gao (11107228)

“…</p>Methods<p>We performed a secondary data analysis of substance use screening responses collected between 2018 and 2022 from individuals aged 12–20 years who were seen at 314 US pediatric practices utilizing the Comprehensive Health and Decision Information System (CHADIS) online clinical process support system. …”

Beta-catenin signaling in the E14.5 cortex. by Christopher A. Mutch (243132)

“…Tbr2 staining suggests a rostral low to caudal gradient. Scale bars are 200 µm (<b>A</b>) 50 µm (<b>B</b>) and 500 µm (<b>C</b>).…”

Myocyte death not vessel density is affected by age. by Nikolai A. Sopko (234668)

“…<p>(A) Representative pictomicrographs of vascular density from BMTx mice. …”

Data_Sheet_1_Lung function benefits of traditional Chinese medicine Qiju granules against fine particulate air pollution exposure: a randomized controlled trial.ZIP by Rucheng Chen (454165)

“…Forced expiratory volume in one second (FEV₁), peak expiratory flow (PEF), maximal mid-expiratory flow (MMEF), forced expiratory flow at 75% of forced vital capacity (FVC) (FEF₇₅), forced expiratory flow at 50% of FVC (FEF₅₀), and forced expiratory flow at 25% of FVC (FEF₂₅) were significantly decreased due to PM_2.5 exposure in the control group. …”

Evaluation of phytochemicals and antioxidant activity of gamma irradiated quinoa (Chenopodium quinoa) by M. A. Abdelaleem (10405403)

<i>skn-1</i> regulates sensory integration in <i>C</i>. <i>elegans</i>. by Mark A. Wilson (208472)

“…(E) <i>skn-1</i> food-leaving behavior is impaired in the presence of very low local concentrations of food (OP50 <i>E</i>. <i>coli</i>). (F) <i>skn-1</i> chemotaxis toward BA is significantly decreased and dwelling behavior enhanced in the presence of known concentrations of bacterial lawn. …”

Mice with older bone marrow (BM) have increased cardiac remodeling compared to young BM mice 4-weeks post-TAC. by Nikolai A. Sopko (234668)

“…<p>(A) Masons trichrome staining for collagen. (B) Young BM mice had increased myocyte hypertrophy compared to old BM mice. n = 12–14 per group. …”

Table 1_Ten days of supplementation with a standardized Boswellia serrata extract attenuates soreness and accelerates recovery after repeated bouts of downhill running in recreatio... by Dawna Salter (18498396)

“…This pilot study evaluated the efficacy of a standardized B. serrata extract LI51202F1 (SBS) to decrease soreness and improve recovery after repeated bouts of downhill running (DHR) compared to placebo (PLA). …”

Image2_First-in-Human, Double-Blind, Randomized, Placebo-Controlled Trial of TQ-F3083, a New Dipeptidyl Peptidase-4 Inhibitor, in Healthy Chinese Adults.TIF by Jingrui Liu (1694983)

“…The accumulation factor was 1.39 after multiple dose for 7 days. Decreased plasma exposure (84.87% decrease in C_max, 49.23% in AUC_0-t, and 47.77% in AUC_0-∞) was observed with administration after a high-fat and high-calorie standardized breakfast. …”

Image1_First-in-Human, Double-Blind, Randomized, Placebo-Controlled Trial of TQ-F3083, a New Dipeptidyl Peptidase-4 Inhibitor, in Healthy Chinese Adults.TIF by Jingrui Liu (1694983)

“…The accumulation factor was 1.39 after multiple dose for 7 days. Decreased plasma exposure (84.87% decrease in C_max, 49.23% in AUC_0-t, and 47.77% in AUC_0-∞) was observed with administration after a high-fat and high-calorie standardized breakfast. …”

Table 2_Global, regional, and national burden of intracerebral hemorrhage and attributable risk factors in youths and young adults, 1990–2021: a statistical analysis of incidence,... by Bing Wu (172312)

“…The incidence rate declined from 11.31 (95% UI, 8.56, 14.27) per 100,000 individuals in 1990 to 8.30 (95% UI, 6.46, 10.19) per 100,000 individuals in 2021, an overall decrease of −26.62% (95% UI, −30.85 to −22.24). Among the five Sociodemographic Index (SDI) regions, the highest EAPCs were observed in the high SDI regions for incidence (−1.63%; 95% CI, −1.74 to −1.52), mortality (−1.79%; 95% CI, −2.01 to −1.58), and DALYs (−1.67%; 95% UI, −1.84 to −1.50). …”

Image3_First-in-Human, Double-Blind, Randomized, Placebo-Controlled Trial of TQ-F3083, a New Dipeptidyl Peptidase-4 Inhibitor, in Healthy Chinese Adults.TIF by Jingrui Liu (1694983)

“…The accumulation factor was 1.39 after multiple dose for 7 days. Decreased plasma exposure (84.87% decrease in C_max, 49.23% in AUC_0-t, and 47.77% in AUC_0-∞) was observed with administration after a high-fat and high-calorie standardized breakfast. …”