Image_2_Sedentary behavior, brain-derived neurotrophic factor and brain structure in midlife: A longitudinal brain MRI sub-study of the coronary artery risk development in young ad... by Xuan Zhang (56049)

“…</p>Results<p>Cross-sectionally, baseline participants with the highest sedentary time had a lower total brain (−12.2 cc; 95%CI: −20.7, −3.7), gray matter (−7.8 cc; 95%CI: −14.3, −1.3), and hippocampal volume (−0.2 cc; 95%CI: −0.3, 0.0) compared with populations with the lowest sedentary time. …”

Image_1_Sedentary behavior, brain-derived neurotrophic factor and brain structure in midlife: A longitudinal brain MRI sub-study of the coronary artery risk development in young ad... by Xuan Zhang (56049)

“…</p>Results<p>Cross-sectionally, baseline participants with the highest sedentary time had a lower total brain (−12.2 cc; 95%CI: −20.7, −3.7), gray matter (−7.8 cc; 95%CI: −14.3, −1.3), and hippocampal volume (−0.2 cc; 95%CI: −0.3, 0.0) compared with populations with the lowest sedentary time. …”

Metabolic effects of exposure to AmB in <i>L</i>. <i>mexicana</i> promastigotes cultured in HOMEM and DM. by Edubiel A. Alpizar-Sosa (13848145)

“…Each line represents one biological replicate (n = 4). Increase (red) or decrease (blue) in fold-change is relative to untreated cells after treatment with AmB at 5 x their EC₅₀ values for 15 mins. …”

DataSheet1_A randomized, open-label, parallel pilot study investigating metabolic product kinetics of the novel ketone ester, bis-hexanoyl (R)-1,3-butanediol, over one week of inge... by Eunice Mah (5918042)

“…</p><p>Methods: We undertook a randomized, parallel, open-label study in healthy adults (n = 33) to elucidate blood BHB, HEX and BDO concentrations for 8 h following consumption of three different serving sizes (SS) of BH-BD (12.5, 25 and 50 g/day) before (Day 0) and after 7 days of daily BH-BD consumption (Day 7).…”

Risk Factors for Mortality from Acute Lower Respiratory Infections (ALRI) in Children under Five Years of Age in Low and Middle-Income Countries: A Systematic Review and Meta-Analy... by Michela Sonego (688099)

SBS 3.1, a novel natural product small molecule regulates TNF-α-induced NF-κB activation and key signals of inflammation to promote apoptosis in lung cancer tumour microenvironment... by Ashish Kumar (152984)

“…MMP BSA analysis of the lead compound predicted a favorable binding free energy. The compound inhibited the proliferations of T NF-α induced A-549 with a GI50 value of 30.53 μM. …”

DataSheet1_The Non-Steroidal Mineralocorticoid Receptor Antagonist KBP-5074 Limits Albuminuria and has Improved Therapeutic Index Compared With Eplerenone in a Rat Model With Miner... by Frédéric Jaisser (4885231)

“…The TI was calculated for each drug as the ratio of the concentration of drug producing 50% of maximum effect (EC₅₀) for increasing serum K⁺ to the EC₅₀ for lowering UACR. …”

Data_Sheet_1_Secular trends of dental caries and association with nutritional status: a retrospective analysis of 16,199 Chinese students from three successive national surveys fro... by Changfu Hao (4023842)

“…The total caries rate decreased with age (p < 0.05), and the caries rate of girls was higher than that of boys in 2019 (55.75% vs. 50.67%) (p < 0.001). …”

Aqueous tear production, tear stability and ocular surface epithelial cell damage assessment. by Osama M. A. Ibrahim (600549)

“…<p>A, The weight adjusted tear quantity decreased significantly from 10 to 50 weeks in the Cu, Zn-Superoxide Dismutase-1 knockout (<i>Sod1</i>^−/−) mice (<i>p</i> = 0.0012). …”

Under microaerobic (1% O₂) conditions in free living cells, the hFixL-FxkR-FixK pathway and not FnrN is a key activator of anaerobox controlled genes. by Paul J. Rutten (10099255)

Table 1_Comparative effectiveness and safety of sodium-glucose cotransporter 2 inhibitors vs glucagon-like peptide 1 receptor agonists in elderly patients with type 2 diabetes mell... by Yao Wang (102387)

Meibomian gland histopathological alterations and tissue fibrosis in the <i>Sod1</i>^−/− and wild type mice. by Osama M. A. Ibrahim (600549)

“…<p>A, Representative images for meibomian glands from the 10 and 50 week Cu, Zn-Superoxide Dismutase-1 knockout (<i>Sod1</i>^−/−) and wild type (WT) mice show normal meibomian gland acinar units morphology. …”

Does the Mediterranean Diet Have Any Effect on Lipid Profile, Central Obesity and Liver Enzymes in Non-Alcoholic Fatty Liver Disease (NAFLD) Subjects? A Systematic Review and Meta-... by Del Bo', Cristian

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Responses to paraquat-induced oxidative stress in transgene flies. by Jeannette A. E. Söderberg (221671)

“…Knockdown of <i>Dilp5</i> leads to a drastic increase in median and total lifespan (P<0.001 and P<0.0005 compared to parental controls; n = 50–60 for the different genotypes) whereas <i>Sod2</i>-RNAi decreases lifespan (P<0.01 and P<0.02 compared to parental controls; n = 50–60 for the different genotypes).…”

<i>skn-1b</i> is not required for WT or <i>daf-2</i> longevity A-F) Survival of WT and <i>skn-1b</i> mutants in the absence and presence of <i>daf-2</i> mutation. by Nikolaos Tataridas-Pallas (10231350)

“…In a total of 15 trials (13 on OP50, 2 on HT115) bacteria we observed a slight decrease in <i>skn-1b</i> longevity compared to WT in 4 trials (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009358#pgen.1009358.s004" target="_blank">S4</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009358#pgen.1009358.s005" target="_blank">S5</a> Tables). …”

Alanyl-glutamine protects the intestinal barrier function in trained rats against the impact of acute exhaustive exercise by A.K.L. Freitas (8743314)

“…<div><p>Strenuous exercise triggers deleterious effects on the intestinal epithelium, but their mechanisms are still uncertain. Here, we investigated whether a prolonged training and an additional exhaustive training protocol alter intestinal permeability and the putative effect of alanyl-glutamine (AG) pretreatment in this condition. …”

Model simulations recover the dual effect of Cactus on Dorsal in <i>cact</i>^<i>A2</i>/<i>cact</i>^<i>011</i> mutant background. by Claudio D. T. Barros (10885464)

“…(D) nDl simulation decreasing k2 by 20%, 30%, 40% or nulling k2 (0%) in a <i>cact</i>^<i>A2</i>/<i>cact</i>^<i>011</i> mutant background comparing to experimental data (circle symbol) and WT and <i>cact</i>^<i>A2</i>/<i>cact</i>^<i>011</i> mutant simulations. …”

A Synthetic, Structural, Magnetic, and Spectral Study of Several {Fe[tris(pyrazolyl)methane]₂}(BF₄)₂ Complexes:  Observation of an Unusual Spin-Sta... by Daniel L. Reger (1444537)

“…Mössbauer spectral studies show conclusively that the magnetic moment change observed at lower temperatures arises from the complex changing from a high-spin state at higher temperatures to a 50:50 mixture of high-spin and low-spin states at lower temperatures. …”

Effects of static defects and nucleosome rate constant variability on RNAPII density profiles. by Robert C. Mines (12072784)

“…<p>All subpanels have <i>h</i>_<i>c</i> increasing from 0.001 to 0.1 from left to right and <i>h</i>_<i>o</i> increasing from 0.001 to 1 from top to bottom as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009811#pcbi.1009811.g002" target="_blank">Fig 2</a>. 50 replicates of <i>N</i>_<i>MCS</i> = 2×10⁶ Monte Carlo steps are performed for all cases. …”

DataSheet_1_SARS-CoV-2 pre-exposure prophylaxis with tixagevimab/cilgavimab (AZD7442) provides protection in inborn errors of immunity with antibody defects: a real-world experienc... by Federica Pulvirenti (8262402)