Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus <i>Penicillium daleae</i> L3SO by Qing-Yuan Wang (11571890)

“…The hypothetical biosynthetic pathways for <b>1</b> and <b>2</b> were postulated and were supported by CRISPR/Cas9 genome editing results. Penidaleodiolide A (<b>1</b>) showed a significant inhibitory effect on the action potentials of murine hippocampal basket neurons and decreased the frequency of spontaneous excitatory postsynaptic currents in a concentration-dependent manner (the inhibition ratios were 0.30 ± 0.02 for 1 μM, 0.37 ± 0.03 for 10 μM, and 0.50 ± 0.07 for 20 μM) while being devoid of cytotoxicity against the nerve cells.…”

Inhibition of <i>in vitro</i> and <i>in vivo</i> inflammatory responses in rats by p30A peptide. by Jérôme Rambert (46851)

“…(D) Histopathologic analysis confirm p30A ability to decrease all components of AIA lesions: pannus formation and inflammation of the synovium (P), deformity of joint and bones (asterix), bone remodeling and destruction (arrowhead), bone neoformation (arrows) and cartilage destruction.…”

Influenza-induced loss of claudin-5 is due to cleavage by matrix metalloproteases. by Susan M. Armstrong (301641)

“…<p>(A) The reduction in claudin-5 levels is not due to decreased transcription. …”

Generation of CYP5122A1 half knock-outs. by Smriti Verma (204089)

“…<b>D:</b> Western blot analysis of cell lysates from WT and HKO parasites probed with anti-CYP5122A1 antibody showing decreased level of CYP5122A1 protein in the HKO parasites. …”

Effects of Cyr61 and Wnt5a on regenerating vasculature and musculature. by Devon C. Snow-Lisy (798898)

“…Scale bar, 50 μm. (Unseeded, MSC and MSC/CD34⁺ HSPC images shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0138643#pone.0138643.s001" target="_blank">S1 Fig</a>).…”

Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2 by Marta E. Capala (652765)

“…Downregulation of SAM50 also impaired the proliferation and replating capacity of BCR-ABL-expressing cells, again associated with a decreased mitochondrial membrane potential. …”

Table_1_Guanidine acetic acid exhibited greater growth performance in younger (13–30 kg) than in older (30–50 kg) lambs under high-concentrate feedlotting pattern.docx by Wen-Juan Li (1444948)

“…In a brief, the results obtained in the present study suggested that GAA (UGAA and CGAA; 1 g/kg DM) could be applied to improve growth performance in younger (13–30 kg) instead of older (30–50 kg) lambs in high-concentrate feedlotting practice.…”

Dietary or gavaged TU-100 and the ginger component decrease enteropooling stimulated by anti-CD3 antibody treatment in specified pathogen free (SPF) and germ free (GF) C57Bl6 mice. by Nobuhiro Ueno (346397)

Knockdown of CRT suppressed VEGF-A expression and mRNA stability through ARE in AGS cells. by Po-Chu Lee (438366)

“…VEGF-A mRNA was significantly less stable in the CRT-knockdown cells with lower half-life and 50% mRNA remaining time. …”

Analysis of Research Activity in Gastroenterology: Pancreatitis Is in Real Danger - Fig 2 by Andrea Szentesi (3239193)

Box plot displaying the distributions of the deconvolution derived proportions of cell types. by Arttu Autio-Kimura (20454681)

Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles <i>in vitro</i> - Fig 4 by Remo Campiche (3714208)

“…Hair follicles treated with lower concentrations of Gambogic Amide kept their anagen-like appearance. Bars = 50 μm. <b>E: Immunohistochemical quantification of melanocytes with p16, a marker for mature and senescent melanocytes</b>. …”

Fig 3 - by Belinda Kweka (9931483)

“…Compared to those without G6PD deficiency, heterozygous females had decreased odds of PD/DM diagnosis (adjusted OR 0.47, 95% CI: 0.22, 0.99, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0244782#pone.0244782.t003" target="_blank">Table 3</a>). …”

A Decomposition analysis of iNTS change in incidence by SDI, 1990 to 2021. Fig 6B. SDI-related health inequality regression for the incidence rate of iNTS worldwide, 1990 and 2021. by Yunjuan He (7107446)

Cell type-specific expression of <i>mif</i>, <i>cd74a</i>, and <i>cd74b</i>. by Safia A. Essien (20108379)

Aflatoxin B₁ Negatively Regulates Wnt/β-Catenin Signaling Pathway through Activating miR-33a by Yi Fang (287944)

“…The level of miR-33a was up-regulated in hepatocellular carcinoma (HCC) cells treated with AFB₁, while in the same cells causing the decrease in β-catenin expression when treated at their IC₅₀ values. miR-33a, specifically miR-33a-5p, was demonstrated to down-regulate the expression of β-catenin, affect the β-catenin pathway, and inhibit cell growth. …”

Structural Alterations of the “Address” Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity by Hongguang Ma (5105198)

Grand average ABR waveforms (N = 8) prior to (black) and following (red) SS-induced tinnitus and elicited by the second 70 dB SPL noise burst (NB2) following a 50 ms silent gap. NB... by Andrea S. Lowe (693855)

Modification of intracellular ROS level abrogates eltrombopag’s effect on AML cells. by Anna Kalota (7415)

Anti-CD25 treatment depletes Foxp3^GFP Treg cells and induces decreased fungal loads in Foxp3^GFP C57BL/6 mice. by Maíra Felonato (296591)