Sustainable mobility at the EU level – in the new transport white paper by Tamas Fleischer (409919)

“…Funded by the European Commission in FP7. Szentendre, Hungary, 5/6 May 2011</p> <p>The main message of the contribution in four points:</p> <p>(1) The environmental targets for 2050 (sixty percent emission decrease, oil dependence decrease) are based on a very progressive vision, clear target.…”

CCDC66-depleted cells exhibit abnormal ciliary signaling and transport. by Jovana Deretic (13113617)

“…Scale bar: 5 µm. Insets show 2.5× magnifications of the cilia, Scale bar: 2 µm <b>(B)</b> Quantification of SMO-positive cilia and ciliary SMO and phospho-SMO concentration in <b>(A)</b>. …”

Examples demonstrating instances where the minimum number of mt protein-coding (PC) genes is either apparent or ambiguous. by Justin C. Havird (507301)

“…In these cases, the minimum number of genes that statistically recreated the “supergene” topology was chosen (e.g., a single gene, NAD5, for Haplorrhini). This alternative trend was atypical of the data (6.5% and 7.0% of lineages when utilizing amino acid and nucleotide data, respectively). …”

Model for the Differentiation of the HMS. by Caleb Gonzalez (270214)

“…<p>(A) We suggest that differentiation of the HMS results from the convergence of three events: acquisition of a DNA double-strand break (DSB) or double-strand end (DSE, one end of a DSB); induction of the SOS DNA-damage response; and induction of the RpoS general stress-response (modified from Figure 5 in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000208#pgen.1000208-Galhardo1" target="_blank">[2]</a>). …”

Endogenous BDNF and TrkB levels in retina and SC at various time points after ONC. by Eline Dekeyster (825249)

“…<p>(A) In the retina, the total BDNF levels, analyzed via ELISA, rise upon ONC, reaching a peak at 3 to 5 d, attenuating afterwards. …”

Smooth muscle differentiation and Notch target genes are down regulated in Notch2 and Notch2/Notch3 double mutants. by Qingqing Wang (141110)

“…Notch signaling target gene Heyl shows a robust decrease at E10.5 and E11.5 in the <i>Notch2^−/− (N2^−/−;N3^+/+)</i> and <i>Notch2^−/−;Notch3^−/− (N2^−/−;N3^−/−)</i> yolk sacs, while Hey2 shows a slight decrease and Hes1 expression is unaffected in the mutant genotypes. …”

Effect of RNAi depletion of selected hits on lipid droplet formation and TOR pathway activation. by Vangelis Kondylis (229490)

“…Red and blue columns indicate proteins whose depletion leads to a significant decrease or increase in the number of lipid droplets (marked with double asterisk; p<0.05). …”

Dopaminergic differentiation deficit persists at later stages in <i>Dkk1</i> mutants. by Diogo Ribeiro (230483)

“…<p>(A) Immunohistochemistry for TH at E17.5 in the VM revealed a decrease in the number of TH+ neurons and an alteration in their distribution. …”

Estimated changes in the frequency resulting from changes in slopes and amplitude agree with simulations. by Daisuke Ohshima (129662)

Supplementary Material for: Biomechanics of the Bat Limb Skeleton: Scaling, Material Properties and Mechanics by Swartz S.M. (3859399)

“…Mineralization in the cortical bone of wings is lower than in the long bones of other adult mammals, with a proximodistal gradient of decreasing mineralization. …”

Synthesis and biological evaluation of quinoxaline derivatives as ASK1 inhibitors by Xiaorui Han (1401655)

“…<p>Inhibiting apoptosis signal regulated kinase 1 (ASK1) is an attractive strategy for treating diseases such as non-alcoholic steatohepatitis and multiple sclerosis. Here, we report the discovery of a dibromo substituted quinoxaline fragment containing <b>26e</b> as an effective small-molecule inhibitor of ASK1, with an IC₅₀ value of 30.17 nM. …”

Hippocampal cell proliferation and neurogenesis in the dentate gyus. by Suk-Yu Yau (205104)

“…However, BDNF level was decreased by CORT in a dose-dependent manner. Running up-regulated BDNF level in 30 mg/kg and 40 mg/kg CORT-treated rats, but not in 50 mg/kg CORT-treated rats. …”

Image_3_High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production.TIF by Tareck Rharass (707643)

“…Without inducers, HG condition also led to decreased leptin mRNA level. Importantly, intracellular and extracellular ROS concentrations measured using Amplex Red were significantly raised by 50% under HG exposure. …”

Image_2_High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production.TIF by Tareck Rharass (707643)

“…Without inducers, HG condition also led to decreased leptin mRNA level. Importantly, intracellular and extracellular ROS concentrations measured using Amplex Red were significantly raised by 50% under HG exposure. …”

Image_4_High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production.pdf by Tareck Rharass (707643)

“…Without inducers, HG condition also led to decreased leptin mRNA level. Importantly, intracellular and extracellular ROS concentrations measured using Amplex Red were significantly raised by 50% under HG exposure. …”

Image_1_High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production.jpg by Tareck Rharass (707643)

“…Without inducers, HG condition also led to decreased leptin mRNA level. Importantly, intracellular and extracellular ROS concentrations measured using Amplex Red were significantly raised by 50% under HG exposure. …”

Video_1_Sensorimotor content of multi-unit activity recorded in the paramedian lobule of the cerebellum using carbon fiber microelectrode arrays.MP4 by Esma Cetinkaya (18073042)

“…Linear regression was performed to predict the EMG signal envelopes using the PML activity for various time shifts (±25, ±50, ±100, and ± 400 ms) between the two signals to determine a causal relation. …”

Application of single step genomic BLUP under different uncertain paternity scenarios using simulated data by Rafael Lara Tonussi (4476496)

“…Four ways of scaling the mean of the genomic matrix (<b>G</b>) to match to the mean of the pedigree relationship matrix among genotyped animals (<b>A</b>₂₂) were tested. Accuracy, bias, and inflation were investigated for five groups of animals: ALL = all animals; BULL = only bulls; GEN = genotyped animals; FEM = females; and YOUNG = young males. …”

Restricting CSPG Secretion to the Acute Stage after Injury Improves Functional Recovery by Asya Rolls (84466)

“…</p> <p>(L) Western blot analysis of CSPG levels in the control group (PBS) and in the groups receiving xyloside treatment on day 0 or day 2 after the injury (excised 7 d after the injury). β-actin was used as a control for protein levels. Fold decrease in CSPG levels, relative to PBS control, are shown (<i>n</i> = 3 mice per group).…”

Blocking the C/EBPβ-Thr217 phosphorylation ameliorates the induction of lung fibrosis by Bleomycin. by Martina Buck (82941)

“…Analysis was performed on day-21. The bars represent 50 µm. <b>A.</b> Representative Mallory's trichrome stain for lung fibrosis (in blue). …”