Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents by Marcian E. Van Dort (21374093)

Subjects:

Stress can increase or decrease anxiety depending on the timing of the stressor by Jason Snyder (96580)

Ageing results in an abrupt decrease in overall neurogenesis in the mouse DG. by Joana Gil-Mohapel (462002)

“…(C) An estimation of overall neurogenesis based on the total number of BrdU-positive cells that survived the 42-day period multiplied by the proportion of BrdU-positive cells that acquired a mature neuronal phenotype indicates an age-induced significant and abrupt decrease in the overall number of new neurons. *** <i>p</i> < 0.001 between 1.5 and 3 months and between 3 and 6 months. …”

Decrease in cleavage score by randomly permuting string-of-beads vaccines. by Emilio Dorigatti (9558024)

“…<p>(a) For each vaccine in the Pareto frontier of each bootstrap, we created 50 new string-of-beads by randomly permuting its epitopes and compared the cleavage scores of the two vaccines. …”

Glycine is able to induce both a motility speed in- and decrease during zebrafish neuronal migration by Ulrike Theisen (4734555)

Anti-CXCR3 group decreased number of specific CD8⁺ T cells as well as polyfunctionality after infection with <i>T</i>. <i>cruzi</i>. by Camila Pontes Ferreira (6194006)

NETs decrease <i>T</i>. <i>cruzi</i> infectivity. by Daniel Sousa-Rocha (802734)

Decrease in GABA_B expression in APP mice. by Ksenia V. Kastanenka (3692380)

Rap1A knockdown <i>in vitro</i> impairs steady state monolayer integrity and decreases transepithelial electrical resistance. by Erika S. Wittchen (256700)

MAP-map analysis of activity decreases within olfactory bulb and preoptic dopaminergic regions. by Jessica C. Nelson (10906236)

Semi-log plot of the FIFA countries ranked by their decreasing “order of importance” through the FIFA coefficient; the best 5-parameter function, Eq (5), is shown. by Marcel Ausloos (748325)

“…<p>Semi-log plot of the FIFA countries ranked by their decreasing “order of importance” through the FIFA coefficient; the best 5-parameter function, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0166011#pone.0166011.e005" target="_blank">Eq (5)</a>, is shown.…”

Supplementary Material for: Platelet Decreases following Continuous Renal Replacement Therapy Initiation as a Novel Risk Factor for Renal Nonrecovery by Griffin B.R. (8570007)

“…<b><i>Results:</i></b> Time to RRT independence censored for death was achieved less frequently in patients with low platelet nadir (hazard ratio [HR] 0.77, confidence interval [CI] 0.66–0.91) and in those with >50% platelet decrease (HR 0.84, CI 0.72–0.97). RRT-free days were lower in both low platelet nadir (odds ratio [OR] 0.94, CI 0.90–0.97) and >50% platelet decrease (OR 0.91, CI 0.88–0.95). …”

Protection of Aβ-mediated neuronal cell death by sRAGE, pyridoxamine or ALT-711 through decreasing RAGE levels. by Kyunghee Byun (162379)

“…(D) *, The number of the triple-labeled cells (AGE/albumin/Iba-1 positive cells) significantly increased in whole EC area of Aβ injected rat brain but decreased dramatically in Aβ/sRAGE treated rat brain (p<0.01). …”

Ivermectin significantly decreases <i>L</i>. <i>loa</i> mf in BALB/c mice. by Rene Bilingwe Ayiseh (6900296)

FOXO3a decreases expression of ER-regulated genes and increases CDK inhibitors in MCF7-FO breast tumors by Yiyu Zou (47196)

Transaldolase deficiency causes a starvation-like response that decreases animal fat content and rewires lipid metabolism gene expression. by Christopher F. Bennett (3875731)

“…<p><b>(A)</b> Intestinal fat staining decreases from RNAi knockdown of <i>tald-1</i> or <i>cco-1</i>. …”

2-ME decreases blood pressure in Sprague Dawley rats. by Weiyu Chen (2216251)

Glutamate excitotoxicity decreases viability of cultured hippocampal GABAergic neurons. by Márcio S. Baptista (365618)

Paired-pulse depression decreases between birth and hearing onset. by Daniel T. Case (350039)

Exogenous FGF4 decreases osteogenic differentiation of mESCs. by Sung-Ho Kook (445098)