Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma by Marzena Mazur (4761027)

“…Rational design, guided by X-ray analysis of several inhibitors bound to human chitotriosidase (hCHIT1), led to the identification of compound <b>7f</b> as a highly potent AMCase inhibitor (IC₅₀ values of 14 and 19 nM against human and mouse enzyme, respectively) and selective (>150× against mCHIT1) with very good PK properties. …”

NBQX increased PNNs (<i>WFA</i>), tenascin-R, aggrecan and Neurocan in the medial prefrontal cortex in PTZ-treated rats. by Wen Chen (30046)

Chronic PTZ treatment reduced PNNs (<i>WFA</i>), tenascin-R, aggrecan and Neurocan in the medial prefrontal cortex. by Wen Chen (30046)

K_v4 is Required for Maintaining Excitability in <i>Drosophila</i> Neurons. by Yong Ping (233004)

“…<p><i>A</i>, Representative firing patterns recorded with current injections of 40, 60, and 100 pA from wild-type (wt) and DNK_v4 (DN) neurons. With increasing current injections, wt neurons display a reduction in the delay to the first AP and an augmentation in AP firing frequency, maintaining excitability for the duration of the 500 ms stimulus. …”

Mean (top panel) and percentile rank (bottom panel) regression estimates of brain tissue volume across age in the AD sample (n=219). by David Alexander Dickie (499804)

“…<p>The slopes of these lines represent the beta coefficients in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084093#pone-0084093-t005" target="_blank">table 5</a>. The mean-based model expects all percentile ranks to change at the same rate, i.e. be parallel. …”

h-S100A7-mediated promotion of α-secretase activity and sAPPα secretion and decreased amyloid-beta_1–42 level are prevented by p42/44MAPK and PKC signal-transduction inhi... by Weiping Qin (585156)

The impact of socioeconomic status on the utilization of total hip arthroplasty during 1995–2017: 104,055 THA cases and 520,275 population controls from national databases in Denma... by Nina M Edwards (9567542)

Density plot with counts, representing birth dates estimated for calves sampled with their mothers during January 2019 and February 2018. by Michelle Gelippi (9580022)

Protein and mRNA expression of Glo-I in pHEP, pHSC and pLSEC in controls, early and advanced cirrhosis. by Marcus Hollenbach (376231)

<i>C</i>. <i>auris</i> uses a unique cell wall mannan layer to evade IL-1R signaling mediated host defense. by Abishek Balakumar (20189865)

Histological analyses performed using KB, CaBP, and SMI-32 staining in sections of the hippocampus. by Shigeyoshi Saito (208866)

DAT and NAT activity and the effects of MPP(+) on mitochondrial activity in SH-SY5Y cells. by Joanna A. Korecka (415952)

“…Mitochondrial intensity is significantly increased in RA treated SH-SY5Y cells treated with 0.01 mM MPP(+) up to 0.05 mM, and significantly decreased in cells treated with 0.1 mM, 0.05 mM and 1 mM MPP(+). …”

Expression of LvrAB requires at least one functional PerR homolog but the absence of LvrAB alone is not solely responsible for avirulence of the <i>perRA/B</i> double mutant. by André A. Grassmann (11141592)

Effect of SILD on STZ-diabetic kidney: modulation of macrophage infiltration. by Mary Anna Venneri (737094)

Effect of freeze-thaw cycling on grain size of biochar - Fig 10 by Zuolin Liu (633898)

Quantitative determination of loss of MMP in SH-SY5Y cells in response to Grx1 knockdown. by Uzma Saeed (49670)

“…<p>Grx1 was downregulated in SH-SY5Y cells using shRNA. Cells were treated with vehicle after transfecting them with empty vector, or with vehicle, α-lipoic acid (100 µM) or cyclosporine A (10 µM), 6 hr post transfection with shRNA to Grx1 and MMP was measured using TMRM as the indicator dye. …”

Effect of freeze-thaw cycling on grain size of biochar - Fig 6 by Zuolin Liu (633898)

Identification of Specific Glycosyltransferases Involved in Flavonol Glucoside Biosynthesis in Ginseng Using Integrative Metabolite Profiles, DIA Proteomics, and Phylogenetic Analy... by Qinggang Yin (10052366)

“…MeJA induced transcripts of UGT73A18 and UGT74T4 by over fourfold, consistent with the decrease of kaempferol 3-<i>O</i>-glucoside, which indicated that these genes may be related to resisting adversity stress in ginseng. …”

Identification of Specific Glycosyltransferases Involved in Flavonol Glucoside Biosynthesis in Ginseng Using Integrative Metabolite Profiles, DIA Proteomics, and Phylogenetic Analy... by Qinggang Yin (10052366)

“…MeJA induced transcripts of UGT73A18 and UGT74T4 by over fourfold, consistent with the decrease of kaempferol 3-<i>O</i>-glucoside, which indicated that these genes may be related to resisting adversity stress in ginseng. …”

Identification of Specific Glycosyltransferases Involved in Flavonol Glucoside Biosynthesis in Ginseng Using Integrative Metabolite Profiles, DIA Proteomics, and Phylogenetic Analy... by Qinggang Yin (10052366)

“…MeJA induced transcripts of UGT73A18 and UGT74T4 by over fourfold, consistent with the decrease of kaempferol 3-<i>O</i>-glucoside, which indicated that these genes may be related to resisting adversity stress in ginseng. …”