Changes in osteoblast differentiation and function of 4 week-old <i>Lmna</i>^−/− mice. by Wei Li (7081)

“…(<b>C</b>) Sections of plastic embedded proximal tibiae (secondary spongiosa) from <i>Lmna</i>^−/− mice and WT controls (n = 10 per group) were stained sequentially with toluidine blue (upper panels, Magnification ×40) for osteoblasts (black arrows) and osteocytes (red arrows) and ALP (lower panels, Magnification ×20) for osteoblasts (arrows). (<b>D</b>) A significant decrease (−47%) in the number of ALP expressing osteoblasts (N.Ob) and a significant decrease in osteocyte number (N.Ot) (−50%) were seen in <i>Lmna</i>^−/− mice compared with WT^+/+ mice. …”

Evolution of mutation rates on simple fitness landscapes with different ruggedness. by Jeff Clune (53764)

“…Although the optimal mutation rate increases as a function of valley size (note the right-shift in the dashed line from top to bottom), the evolved mutation rates in fact decrease as a function of valley size (note the left-shift of the blue and red points from top to bottom).…”

Efficiency and range of DpnI pull-down. by Helen E. Barnes (639300)

Effect of Weld Parameters on Residual Stress, Hardness and Microstructure of Dissimilar AA2024-T3 and AA7475-T761 Friction Stir Welded Joints by Sergio Delijaicov (5551979)

Cardiac response to Painless activation by elevated temperature. by Sébastien Sénatore (80383)

“…In the mutant, like for both lower temperatures, increasing the temperature to 50°C induced a strong tachycardia but no cardiac arrest is visible. …”

Supplementary file 3_The proliferation rates of HT-1080 human fibrosarcoma cells can be accelerated or inhibited by weak static and extremely low frequency magnetic fields.zip by Marek Bajtoš (21532052)

image_1_The Severe Deficiency of the Somatotrope GH-Releasing Hormone/Growth Hormone/Insulin-Like Growth Factor 1 Axis of Ghrh−/− Mice Is Associated With an Important Splenic Atrop... by Gwennaelle Bodart (5343917)

Wnt/β-catenin positive clones display increased adhesiveness and disrupt patterning. by Jakob Rosenbauer (5576063)

Trolox equivalent antioxidant capacity of Coffea arabica L. seeds by Iara Alves Ferreira (13219000)

M002 treatment of malignant rhabdoid kidney tumor xenografts. by Michael L. Megison (469463)

“…In the M002 treated G401 xenografts, there was a significant decrease in tumor growth that began at day 7 following treatment that continued to the end of the study. …”

table_1_The Severe Deficiency of the Somatotrope GH-Releasing Hormone/Growth Hormone/Insulin-Like Growth Factor 1 Axis of Ghrh−/− Mice Is Associated With an Important Splenic Atrop... by Gwennaelle Bodart (5343917)

Image texture parameter “granularity” for analysis of early mHTT aggregation. by Nikisha Carty (395638)

Transgenerational phenotypes. by Michael J. Carvan III (591743)

Functional <i>in vitro</i> study on hsa-miR-9*. by Anna Onnis (361465)

“…The level of hsa-mir-9* increased in a dose-dependent manner. <b>(B) Relative expression by qRT-PCR of hsa-mir-9* in LCL transfected with an hsa-miR-9* inhibitor</b>, at the concentration of 50 nM, compared to non-treated LCL and LCL trasfected with a negative control (I NC). …”

Effects of the activation and inhibition of NOTCH signalling on spinal cord progenitor cell proliferation and neuronal generation. by Barbara Hämmerle (36261)

“…<p>A–A′. Confocal projection over 50 µm at the level of the 12^th and 13^th somites of an HH13 embryo that was electroporated with NICD at stage HH10. …”

Quantitative PCR validation of mitochondrial genes. by Kwang H. Choi (121395)

“…<p>A scatter plot with a line of best fit demonstrates that each gene in the PFC shows either increase or decrease in expression across age (qv <0.05). …”

Inhibitors of 5-LOX block TRPM7-mediated cell rounding. by Hsiang-Chin Chen (247146)

“…An asterisk indicates treatments that produced a decrease in cell rounding that was significantly different from 293-TRPM7 cells grown in tetracycline.…”

MCCD ventilation - Case-Figure 7 by Stefan Schaller (4976000)

“…The drop in the ventilation rate between 18:50 and 19:10 minutes was due to a leak in the airway circuit. …”

Sensitivity Analysis of Increasing Baseline Effectiveness of Self-Administered Antiretroviral Therapy. by Caitlin J. McCabe (365598)

“…As the proportion of women who have a full response to self-administered HAART increases, there is a decrease in the proportion of women for whom DOT is cost-effective. …”

Sensitivity analysis. by Billy J. Gardner (10988034)

“…<p>The plot shows how much R_t changes from a 10% increase (red) or 10% decrease (blue) in that model parameter relative to values in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009122#pcbi.1009122.t001" target="_blank">Table 1</a> (with τ_Is = 0.2 and κ = 1). …”