Group I PAK Inhibitor IPA-3 Induces Cell Death and Affects Cell Adhesivity to Fibronectin in Human Hematopoietic Cells by Kateřina Kuželová (541883)

“…IPA-3 induced cell death with EC50 ranging from 5 to more than 20 μM. Similar range was found for IPA-3-mediated dephosphorylation of a known PAK downstream effector, cofilin. …”

Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation by Zeynep BAYRAMOGLU (13826448)

“…<div><p>Abstract The role of oxidative stress, as well as inflammation in the pathogenesis of methotrexate (MTX)-induced oral mucositis, is a known fact. The anti-inflammatory, antitumor, antimicrobial, and antioxidant properties of taxifolin—the effect we tested against MTX-induced oral mucosal damage—are well known. …”

Forskolin increases the presynaptic surface area of glutamate release and the spatial synchronization of glutamate release within hMFBs. by Marta Orlando (11001599)

“…Suprathreshold pixels (pixels with Δ<i>F/F</i> intensities more than 3 × SD of the baseline signal, i.e., 50 ms before the stimulation) are contoured with a black line and represent the active area. …”

Factors associated with the <i>SS</i> Positives. by Anuradha Rajamanickam (5278013)

“…<div><p><i>Strongyloides stercoralis (Ss)</i> is a parasitic infection affecting 50–100 million people globally, with significant immune and metabolic consequences, particularly in immunocompromised individuals. …”

Effect of XO inhibitor allopurinol (ALLO) on IH-induced autonomic dysfunction. by Jayasri Nanduri (467086)

Impact of the 2009 US Preventive Services Task Force Guidelines on Screening Mammography Rates on Women in Their 40s by Amy T. Wang (533749)

“…Time-series regression models were estimated to determine the effect of the guideline change on screening mammography rates. 5.5 million women ages 40–64 were included. A 1.8 per 1,000 women (p = 0.003) decrease in monthly screening mammography rates for 40–49 year-old women was observed two months following the guideline change; no initial effect was seen for 50–64 year-old women. …”

Effect of mobile text messages on antiretroviral medication adherence and patient retention in early HIV care: An open-label, randomized, single center study in south Florida by Sherman, Elizabeth M.

“…Background People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. …”
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Table 1_The clinical prediction model to distinguish between colonization and infection by Klebsiella pneumoniae.xlsx by Xiaoyu Zhang (62901)

“…The importance of each factor was demonstrated using mean decrease in Gini. “Admitted with a diagnosis of respiratory infectious disease” (8.39) was identified as the most important factor in the model, followed by “Hypoalbuminemia” (7.83), then “ESBL” (7.06), “Electrolyte Imbalance” (5.81), “Age > 62 years” (5.24), “The number of Positive Sputum Cultures for KP > 2” (4.77), and being bedridden (4.24). …”

Exocytosis of ATP from astrocytes <i>in situ</i> can be triggered by synaptic stimulation. by Ulyana Lalo (506296)

“…Spontaneous currents recorded in the pyramidal neurons at a holding potential of −80 mV in the presence of picrotoxin (100 µM) and CNQX (50 µM) were mediated by P2X receptors, as verified by inhibition with selective P2X antagonist NF279 (3 µM). …”

Data_Sheet_1_Sepsis Disrupts Mitochondrial Function and Diaphragm Morphology.docx by Thamires Siqueira Oliveira (11398496)

“…Total and healthy mitochondria were reduced by 30% in septic mice, which may be associated with a 50% decrease in Ppargc1a (encoding PGC1a) and Opa1 (mitochondria fusion marker) expressions in the septic diaphragm. …”

DataSheet1_Arctic stratosphere changes in the 21st century in the Earth system model SOCOLv4.pdf by Pavel Vargin (16809465)

“…In the late 21st century, the strengthening of the zonal mean meridional heat flux with a maximum of up to 20 K m/s (∼25%) in the upper stratosphere close to 70°N in January–February is obtained in the moderate scenario of GHG emission, while only a slight increase in this parameter over 50 N–60 N with the maximum up to 5 K m/s in the upper stratosphere and a decrease with the comparable values over the high latitudes is revealed in the severe GHG emission scenario. …”

Layer-specific quantification of RS and FS neurons in wM1 across learning. by Vahid Esmaeili (12700352)

“…Left: baseline-subtracted (50 ms prior to whisker onset) population firing rate (mean ± SEM) for different cortical layers (L2/3, L5, and L6a) overlaid for Novice (147 neurons in 7 mice) and Expert (452 neurons in 11 mice) mice. …”

The immune control exerted by lytic and non-lytic CD8+ T cell responses. by Nafisa-Katrin Seich al Basatena (201133)

“…Here we show the results for the non-lytic control that blocks viral infection, similar results were found for non-lytic control that blocks viral production (Figures S6, S7 in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003656#ppat.1003656.s001" target="_blank">Text S1</a> and data not shown). …”

Comparative Proteomics Unravels the Differences in Salt Stress Response of Own-Rooted and 110R-Grafted Thompson Seedless Grapevines by Sucheta Patil (8162292)

Table_1_Baseline mitochondrial DNA copy number and heart failure incidence and its role in overall and heart failure mortality in middle-aged women.pdf by Kristina Sundquist (83374)

“…Baseline levels of mtDNA-CN were quantified by droplet digital PCR in a population-based follow-up study of middle-aged (50–59 years) Swedish women (n = 2,508). …”

Image_2_Pulsed Infrared Stimulation of Vertical Semicircular Canals Evokes Cardiovascular Changes in the Rat.eps by Darrian Rice (10888116)

Image_6_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_4_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_1_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_5_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”