Terpenoids decrease single-channel activity of L-AChRs elicited by ACh. by Guillermina Hernando (553795)

Conditional <i>Aff4</i> knockout decreases fat mass in mice. by Yaqian Chen (1711576)

CNP decrease mitochondrial membrane potential and induce mitochondrial fragmentation in melanoma cells. by Elif Aplak (7430123)

“…<p>A, 300 μM CNP (4 h) significantly decreased mitochondrial membrane potential in A375 cells, but not in melanocytes, indicated by changes of TMRM dependent fluorescence in mitochondria. …”

Apicoplast inhibitors decrease global parasite prenylation in the second IDC after treatment. by Kit Kennedy (4915510)

cIN accumulate in the ventrolateral cortex of <i>Emx1</i>-cKO mice. by Sathish Venkataramanappa (10331993)

mTORC1 hyperactivation led to a decreased autophagic activity in the podocytes. by Wakiko Iwata (8600457)

“…The white box indicates the location of the magnified figure. Scale bar: 50 μm. (<b>bottom, right</b>) Quantitative analysis of autophagic activity <i>in vivo</i>. …”

The introduction of mutualisms into assembled communities increases their connectance and complexity while decreasing their richness. by Gui Araujo (22170819)

“…<p>Using the invasion model, we investigate the effect of switching on and off (black vs grey) invasions with mutualisms halfway through the simulation (i.e. after 500 assembly events). …”

Numbers of all fractures, arranged in order of decreasing mean age and with proportion of each of the fracture types in patients over 50, 65, and 75 years of age. by Camilla Bergh (9904522)

“…<p>Numbers of all fractures, arranged in order of decreasing mean age and with proportion of each of the fracture types in patients over 50, 65, and 75 years of age.…”

S1 Dataset - by Nelmo Jordão Manjate (16324619)

Subjects:

No discernible effect of high-dose 5-HT_2AR blockade on error rates in the reward-size task. by Yukiko Hori (299784)

Subjects:

HE staining results of lung tissue of guinea pigs in each group (×200,scale = 50μm). by Fangwei Xu (11845586)

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Inhibiting translation in 5-HT neurons does not recapitulate a <i>Minute</i> phenotype. by Lisa Patricia Deliu (13570709)

Estimated mean values for light interception. by Torsten Schober (20485754)

“…However, with increasing PD, the proportion of higher-concentrated inflorescence fractions from upper canopy layers increased from 46% to 68%, while an extension of DVP shifted this proportion only marginally from 45% to 50%. In the context of standardized production, we therefore advocate high-density production systems that increase the proportion of desired inflorescence fractions from upper canopy layers.…”

Absence of Jag2 alleviates hypoxia-induced oxidative stress injury in rats. by Hanhan Liu (568151)

Subjects:

Jag2 expression is upregulated in hypoxia-treated rats and PASMCs. by Hanhan Liu (568151)

Subjects:

Inhibition of Jag2 effectively ameliorates hypoxia-induced PH in rats. by Hanhan Liu (568151)

Subjects:

Cell viability of U-87 MG cell cultures treated with Ser/5-HT or fluoxetine. by Glaucia Vilar-Pereira (686134)

FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. by Laura L. Stafman (6577184)

“…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD₅₀ = 8.4 μM, p ≤ 0.05). (B) Following 24 hours of treatment with FTY720, the proliferation of HuH6 cells measured using the CellTiter 96 cell proliferation assay was significantly decreased (IC₅₀ = 6.4 μM, p ≤ 0.05). …”